Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6YRM

Transaldolase variant T30A from T. acidophilum in complex with D-fructose 6-phosphate Schiff-base intermediate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004801	molecular_function	transaldolase activity
A	0005737	cellular_component	cytoplasm
A	0005975	biological_process	carbohydrate metabolic process
A	0006098	biological_process	pentose-phosphate shunt
A	0016740	molecular_function	transferase activity
A	0016832	molecular_function	aldehyde-lyase activity
B	0004801	molecular_function	transaldolase activity
B	0005737	cellular_component	cytoplasm
B	0005975	biological_process	carbohydrate metabolic process
B	0006098	biological_process	pentose-phosphate shunt
B	0016740	molecular_function	transferase activity
B	0016832	molecular_function	aldehyde-lyase activity
C	0004801	molecular_function	transaldolase activity
C	0005737	cellular_component	cytoplasm
C	0005975	biological_process	carbohydrate metabolic process
C	0006098	biological_process	pentose-phosphate shunt
C	0016740	molecular_function	transferase activity
C	0016832	molecular_function	aldehyde-lyase activity
D	0004801	molecular_function	transaldolase activity
D	0005737	cellular_component	cytoplasm
D	0005975	biological_process	carbohydrate metabolic process
D	0006098	biological_process	pentose-phosphate shunt
D	0016740	molecular_function	transferase activity
D	0016832	molecular_function	aldehyde-lyase activity
E	0004801	molecular_function	transaldolase activity
E	0005737	cellular_component	cytoplasm
E	0005975	biological_process	carbohydrate metabolic process
E	0006098	biological_process	pentose-phosphate shunt
E	0016740	molecular_function	transferase activity
E	0016832	molecular_function	aldehyde-lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue F6R A 301

Chain	Residue
A	ASP6
A	ARG135
A	ALA166
A	SER167
A	HOH418
A	HOH421
A	THR26
A	THR27
A	ASN28
A	LYS86
A	ASN108
A	THR110
A	SER130
A	PHE132

site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 302

Chain	Residue
A	ASP142
A	GLN145
A	HOH425
A	HOH473
D	MET149
E	ARG176

site_id	AC3
Number of Residues	5
Details	binding site for residue ACT A 304

Chain	Residue
A	MET1
A	HOH420
E	LEU119
E	LYS123
E	TYR157

site_id	AC4
Number of Residues	6
Details	binding site for residue ACT B 303

Chain	Residue
B	ARG169
B	ASN170
B	HOH401
D	ARG169
D	ASN170
D	HOH434

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL C 302

Chain	Residue
C	ASP142
C	GLN145
C	ARG176
C	HOH442
C	HOH451

site_id	AC6
Number of Residues	11
Details	binding site for residue GOL C 303

Chain	Residue
C	ASP137
C	ASN170
C	ASN170
C	ILE172
C	ILE172
C	HIS173
C	HIS173
C	ARG176
C	ARG176
C	HOH405
C	HOH405

site_id	AC7
Number of Residues	8
Details	binding site for residue ACT C 304

Chain	Residue
C	ARG169
C	ARG169
C	ASN170
C	ASN170
C	HOH406
C	HOH406
C	HOH452
C	HOH452

site_id	AC8
Number of Residues	7
Details	binding site for residue ACT E 303

Chain	Residue
A	ARG169
A	ASN170
A	HOH485
E	ARG169
E	ASN170
E	HOH402
E	HOH416

site_id	AC9
Number of Residues	32
Details	binding site for residues GOL A 303 and GOL E 302

Chain	Residue
A	ASP137
A	ASP142
A	GLN145
A	ARG169
A	ASN170
A	ASN170
A	ILE172
A	ILE172
A	HIS173
A	HIS173
A	ARG176
A	ARG176
A	HOH404
A	HOH404
A	HOH425
A	HOH473
A	HOH485
D	MET149
E	ASP137
E	ARG169
E	ASN170
E	ASN170
E	ILE172
E	ILE172
E	HIS173
E	HIS173
E	ARG176
E	ARG176
E	HOH402
E	HOH416
E	HOH418
E	HOH418

site_id	AD1
Number of Residues	32
Details	binding site for residues GOL A 303 and GOL E 302

Chain	Residue
A	ASN170
A	ILE172
A	ILE172
A	HIS173
A	HIS173
A	ARG176
A	ARG176
A	HOH404
A	HOH404
A	HOH425
A	HOH473
A	HOH485
D	MET149
E	ASP137
E	ARG169
E	ASN170
E	ASN170
E	ILE172
E	ILE172
E	HIS173
E	HIS173
E	ARG176
E	ARG176
E	HOH402
E	HOH416
E	HOH418
E	HOH418
A	ASP137
A	ASP142
A	GLN145
A	ARG169
A	ASN170

site_id	AD2
Number of Residues	32
Details	binding site for residues GOL A 303 and GOL E 302

Chain	Residue
A	ASP137
A	ASP142
A	GLN145
A	ARG169
A	ASN170
A	ASN170
A	ILE172
A	ILE172
A	HIS173
A	HIS173
A	ARG176
A	ARG176
A	HOH404
A	HOH404
A	HOH425
A	HOH473
A	HOH485
D	MET149
E	ASP137
E	ARG169
E	ASN170
E	ASN170
E	ILE172
E	ILE172
E	HIS173
E	HIS173
E	ARG176
E	ARG176
E	HOH402
E	HOH416
E	HOH418
E	HOH418

site_id	AD3
Number of Residues	32
Details	binding site for residues GOL A 303 and GOL E 302

Chain	Residue
A	ASP137
A	ASP142
A	GLN145
A	ARG169
A	ASN170
A	ASN170
A	ILE172
A	ILE172
A	HIS173
A	HIS173
A	ARG176
A	ARG176
A	HOH404
A	HOH404
A	HOH425
A	HOH473
A	HOH485
D	MET149
E	ASP137
E	ARG169
E	ASN170
E	ASN170
E	ILE172
E	ILE172
E	HIS173
E	HIS173
E	ARG176
E	ARG176
E	HOH402
E	HOH416
E	HOH418
E	HOH418

site_id	AD4
Number of Residues	20
Details	binding site for Di-peptide F6R B 301 and LYS B 86

Chain	Residue
B	ASP6
B	THR27
B	ASN28
B	SER58
B	VAL59
B	GLU60
B	VAL61
B	VAL84
B	VAL85
B	ILE87
B	ASN108
B	THR110
B	SER130
B	PHE132
B	ARG135
B	ALA166
B	SER167
B	HOH406
B	HOH416
B	HOH428

site_id	AD5
Number of Residues	21
Details	binding site for residues GOL B 302 and GOL D 302

Chain	Residue
B	ASP137
B	ASN170
B	ASN170
B	ILE172
B	ILE172
B	HIS173
B	HIS173
B	ARG176
B	ARG176
B	HOH420
B	HOH420
D	ASP137
D	ASN170
D	ASN170
D	ILE172
D	HIS173
D	HIS173
D	ARG176
D	ARG176
D	HOH403
D	HOH403

site_id	AD6
Number of Residues	21
Details	binding site for residues GOL B 302 and GOL D 302

Chain	Residue
B	ASP137
B	ASN170
B	ASN170
B	ILE172
B	ILE172
B	HIS173
B	HIS173
B	ARG176
B	ARG176
B	HOH420
B	HOH420
D	ASP137
D	ASN170
D	ASN170
D	ILE172
D	HIS173
D	HIS173
D	ARG176
D	ARG176
D	HOH403
D	HOH403

site_id	AD7
Number of Residues	21
Details	binding site for residues GOL B 302 and GOL D 302

Chain	Residue
B	ASP137
B	ASN170
B	ASN170
B	ILE172
B	ILE172
B	HIS173
B	HIS173
B	ARG176
B	ARG176
B	HOH420
B	HOH420
D	ASP137
D	ASN170
D	ASN170
D	ILE172
D	HIS173
D	HIS173
D	ARG176
D	ARG176
D	HOH403
D	HOH403

site_id	AD8
Number of Residues	21
Details	binding site for residues GOL B 302 and GOL D 302

Chain	Residue
B	ASP137
B	ASN170
B	ASN170
B	ILE172
B	ILE172
B	HIS173
B	HIS173
B	ARG176
B	ARG176
B	HOH420
B	HOH420
D	ASP137
D	ASN170
D	ASN170
D	ILE172
D	HIS173
D	HIS173
D	ARG176
D	ARG176
D	HOH403
D	HOH403

site_id	AD9
Number of Residues	21
Details	binding site for residues GOL B 302 and GOL D 302

Chain	Residue
B	ASP137
B	ASN170
B	ASN170
B	ILE172
B	ILE172
B	HIS173
B	HIS173
B	ARG176
B	ARG176
B	HOH420
B	HOH420
D	ASP137
D	ASN170
D	ASN170
D	ILE172
D	HIS173
D	HIS173
D	ARG176
D	ARG176
D	HOH403
D	HOH403

site_id	AE1
Number of Residues	21
Details	binding site for residues GOL B 302 and GOL D 302

Chain	Residue
B	ASP137
B	ASN170
B	ASN170
B	ILE172
B	ILE172
B	HIS173
B	HIS173
B	ARG176
B	ARG176
B	HOH420
B	HOH420
D	ASP137
D	ASN170
D	ASN170
D	ILE172
D	HIS173
D	HIS173
D	ARG176
D	ARG176
D	HOH403
D	HOH403

site_id	AE2
Number of Residues	21
Details	binding site for residues GOL B 302 and GOL D 302

Chain	Residue
B	ASP137
B	ASN170
B	ASN170
B	ILE172
B	ILE172
B	HIS173
B	HIS173
B	ARG176
B	ARG176
B	HOH420
B	HOH420
D	ASP137
D	ASN170
D	ASN170
D	ILE172
D	HIS173
D	HIS173
D	ARG176
D	ARG176
D	HOH403
D	HOH403

site_id	AE3
Number of Residues	21
Details	binding site for residues GOL B 302 and GOL D 302

Chain	Residue
B	ASP137
B	ASN170
B	ASN170
B	ILE172
B	ILE172
B	HIS173
B	HIS173
B	ARG176
B	ARG176
B	HOH420
B	HOH420
D	ASP137
D	ASN170
D	ASN170
D	ILE172
D	HIS173
D	HIS173
D	ARG176
D	ARG176
D	HOH403
D	HOH403

site_id	AE4
Number of Residues	21
Details	binding site for Di-peptide F6R C 301 and LYS C 86

Chain	Residue
C	ASP6
C	THR26
C	THR27
C	ASN28
C	SER58
C	VAL59
C	GLU60
C	VAL61
C	VAL84
C	VAL85
C	ILE87
C	ASN108
C	THR110
C	SER130
C	PHE132
C	ARG135
C	ALA166
C	SER167
C	HOH401
C	HOH421
C	HOH428

site_id	AE5
Number of Residues	19
Details	binding site for Di-peptide F6R D 301 and LYS D 86

Chain	Residue
D	ASP6
D	THR27
D	ASN28
D	SER58
D	VAL59
D	GLU60
D	VAL61
D	VAL84
D	VAL85
D	ILE87
D	ASN108
D	THR110
D	SER130
D	PHE132
D	ARG135
D	ALA166
D	SER167
D	HOH410
D	HOH415

site_id	AE6
Number of Residues	18
Details	binding site for Di-peptide F6R E 301 and LYS E 86

Chain	Residue
E	ASP6
E	THR27
E	ASN28
E	SER58
E	VAL59
E	GLU60
E	VAL61
E	VAL84
E	VAL85
E	ILE87
E	ASN108
E	THR110
E	SER130
E	PHE132
E	ARG135
E	ALA166
E	SER167
E	HOH423

Functional Information from PROSITE/UniProt

site_id	PS00958
Number of Residues	18
Details	TRANSALDOLASE_2 Transaldolase active site. AvVKIPmTeDGLrAiKtL

Chain	Residue	Details
A	ALA83-LEU100

site_id	PS01054
Number of Residues	9
Details	TRANSALDOLASE_1 Transaldolase signature 1. GVTTNPALI

Chain	Residue	Details
A	GLY24-ILE32

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: Schiff-base intermediate with substrate => ECO:0000250

Chain	Residue	Details
A	LYS86
B	LYS86
C	LYS86
D	LYS86
E	LYS86

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)