Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6YR6

14-3-3 sigma in complex with hDM2-186 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001836	biological_process	release of cytochrome c from mitochondria
A	0003334	biological_process	keratinocyte development
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006469	biological_process	negative regulation of protein kinase activity
A	0006611	biological_process	protein export from nucleus
A	0007165	biological_process	signal transduction
A	0008104	biological_process	protein localization
A	0008426	molecular_function	protein kinase C inhibitor activity
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0010482	biological_process	regulation of epidermal cell division
A	0010839	biological_process	negative regulation of keratinocyte proliferation
A	0019901	molecular_function	protein kinase binding
A	0022407	biological_process	regulation of cell-cell adhesion
A	0030216	biological_process	keratinocyte differentiation
A	0030307	biological_process	positive regulation of cell growth
A	0031424	biological_process	keratinization
A	0032880	biological_process	regulation of protein localization
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0043588	biological_process	skin development
A	0043616	biological_process	keratinocyte proliferation
A	0045296	molecular_function	cadherin binding
A	0045606	biological_process	positive regulation of epidermal cell differentiation
A	0045785	biological_process	positive regulation of cell adhesion
A	0045824	biological_process	negative regulation of innate immune response
A	0046827	biological_process	positive regulation of protein export from nucleus
A	0050815	molecular_function	phosphoserine residue binding
A	0051219	molecular_function	phosphoprotein binding
A	0051715	biological_process	cytolysis in another organism
A	0051726	biological_process	regulation of cell cycle
A	0061436	biological_process	establishment of skin barrier
A	0070062	cellular_component	extracellular exosome
A	0072089	biological_process	stem cell proliferation
A	0140311	molecular_function	protein sequestering activity
A	0141156	biological_process	cAMP/PKA signal transduction
A	0160075	biological_process	non-canonical inflammasome complex assembly
A	1903077	biological_process	negative regulation of protein localization to plasma membrane
A	1903829	biological_process	positive regulation of protein localization
A	2000647	biological_process	negative regulation of stem cell proliferation
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0001836	biological_process	release of cytochrome c from mitochondria
C	0003334	biological_process	keratinocyte development
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006469	biological_process	negative regulation of protein kinase activity
C	0006611	biological_process	protein export from nucleus
C	0007165	biological_process	signal transduction
C	0008104	biological_process	protein localization
C	0008426	molecular_function	protein kinase C inhibitor activity
C	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
C	0010482	biological_process	regulation of epidermal cell division
C	0010839	biological_process	negative regulation of keratinocyte proliferation
C	0019901	molecular_function	protein kinase binding
C	0022407	biological_process	regulation of cell-cell adhesion
C	0030216	biological_process	keratinocyte differentiation
C	0030307	biological_process	positive regulation of cell growth
C	0031424	biological_process	keratinization
C	0032880	biological_process	regulation of protein localization
C	0042742	biological_process	defense response to bacterium
C	0042802	molecular_function	identical protein binding
C	0043588	biological_process	skin development
C	0043616	biological_process	keratinocyte proliferation
C	0045296	molecular_function	cadherin binding
C	0045606	biological_process	positive regulation of epidermal cell differentiation
C	0045785	biological_process	positive regulation of cell adhesion
C	0045824	biological_process	negative regulation of innate immune response
C	0046827	biological_process	positive regulation of protein export from nucleus
C	0050815	molecular_function	phosphoserine residue binding
C	0051219	molecular_function	phosphoprotein binding
C	0051715	biological_process	cytolysis in another organism
C	0051726	biological_process	regulation of cell cycle
C	0061436	biological_process	establishment of skin barrier
C	0070062	cellular_component	extracellular exosome
C	0072089	biological_process	stem cell proliferation
C	0140311	molecular_function	protein sequestering activity
C	0141156	biological_process	cAMP/PKA signal transduction
C	0160075	biological_process	non-canonical inflammasome complex assembly
C	1903077	biological_process	negative regulation of protein localization to plasma membrane
C	1903829	biological_process	positive regulation of protein localization
C	2000647	biological_process	negative regulation of stem cell proliferation
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0001836	biological_process	release of cytochrome c from mitochondria
E	0003334	biological_process	keratinocyte development
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006469	biological_process	negative regulation of protein kinase activity
E	0006611	biological_process	protein export from nucleus
E	0007165	biological_process	signal transduction
E	0008104	biological_process	protein localization
E	0008426	molecular_function	protein kinase C inhibitor activity
E	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
E	0010482	biological_process	regulation of epidermal cell division
E	0010839	biological_process	negative regulation of keratinocyte proliferation
E	0019901	molecular_function	protein kinase binding
E	0022407	biological_process	regulation of cell-cell adhesion
E	0030216	biological_process	keratinocyte differentiation
E	0030307	biological_process	positive regulation of cell growth
E	0031424	biological_process	keratinization
E	0032880	biological_process	regulation of protein localization
E	0042742	biological_process	defense response to bacterium
E	0042802	molecular_function	identical protein binding
E	0043588	biological_process	skin development
E	0043616	biological_process	keratinocyte proliferation
E	0045296	molecular_function	cadherin binding
E	0045606	biological_process	positive regulation of epidermal cell differentiation
E	0045785	biological_process	positive regulation of cell adhesion
E	0045824	biological_process	negative regulation of innate immune response
E	0046827	biological_process	positive regulation of protein export from nucleus
E	0050815	molecular_function	phosphoserine residue binding
E	0051219	molecular_function	phosphoprotein binding
E	0051715	biological_process	cytolysis in another organism
E	0051726	biological_process	regulation of cell cycle
E	0061436	biological_process	establishment of skin barrier
E	0070062	cellular_component	extracellular exosome
E	0072089	biological_process	stem cell proliferation
E	0140311	molecular_function	protein sequestering activity
E	0141156	biological_process	cAMP/PKA signal transduction
E	0160075	biological_process	non-canonical inflammasome complex assembly
E	1903077	biological_process	negative regulation of protein localization to plasma membrane
E	1903829	biological_process	positive regulation of protein localization
E	2000647	biological_process	negative regulation of stem cell proliferation
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0001836	biological_process	release of cytochrome c from mitochondria
G	0003334	biological_process	keratinocyte development
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006469	biological_process	negative regulation of protein kinase activity
G	0006611	biological_process	protein export from nucleus
G	0007165	biological_process	signal transduction
G	0008104	biological_process	protein localization
G	0008426	molecular_function	protein kinase C inhibitor activity
G	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
G	0010482	biological_process	regulation of epidermal cell division
G	0010839	biological_process	negative regulation of keratinocyte proliferation
G	0019901	molecular_function	protein kinase binding
G	0022407	biological_process	regulation of cell-cell adhesion
G	0030216	biological_process	keratinocyte differentiation
G	0030307	biological_process	positive regulation of cell growth
G	0031424	biological_process	keratinization
G	0032880	biological_process	regulation of protein localization
G	0042742	biological_process	defense response to bacterium
G	0042802	molecular_function	identical protein binding
G	0043588	biological_process	skin development
G	0043616	biological_process	keratinocyte proliferation
G	0045296	molecular_function	cadherin binding
G	0045606	biological_process	positive regulation of epidermal cell differentiation
G	0045785	biological_process	positive regulation of cell adhesion
G	0045824	biological_process	negative regulation of innate immune response
G	0046827	biological_process	positive regulation of protein export from nucleus
G	0050815	molecular_function	phosphoserine residue binding
G	0051219	molecular_function	phosphoprotein binding
G	0051715	biological_process	cytolysis in another organism
G	0051726	biological_process	regulation of cell cycle
G	0061436	biological_process	establishment of skin barrier
G	0070062	cellular_component	extracellular exosome
G	0072089	biological_process	stem cell proliferation
G	0140311	molecular_function	protein sequestering activity
G	0141156	biological_process	cAMP/PKA signal transduction
G	0160075	biological_process	non-canonical inflammasome complex assembly
G	1903077	biological_process	negative regulation of protein localization to plasma membrane
G	1903829	biological_process	positive regulation of protein localization
G	2000647	biological_process	negative regulation of stem cell proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue IOD A 302

Chain	Residue
E	LYS9

site_id	AC2
Number of Residues	1
Details	binding site for residue IOD A 303

Chain	Residue
A	SER146

site_id	AC3
Number of Residues	1
Details	binding site for residue IOD C 301

Chain	Residue
C	LYS9

site_id	AC4
Number of Residues	1
Details	binding site for residue IOD C 302

Chain	Residue
C	SER146

site_id	AC5
Number of Residues	10
Details	binding site for residue B3P C 303

Chain	Residue
C	ASP97
C	ASP139
C	HOH405
C	HOH449
C	HOH450
A	GLN93
A	ASP97
A	ASP139
A	HOH471
C	GLN93

site_id	AC6
Number of Residues	1
Details	binding site for residue IOD E 301

Chain	Residue
A	LYS9

site_id	AC7
Number of Residues	1
Details	binding site for residue IOD E 302

Chain	Residue
E	SER146

site_id	AC8
Number of Residues	1
Details	binding site for residue IOD G 301

Chain	Residue
G	LYS9

site_id	AC9
Number of Residues	2
Details	binding site for residue IOD G 302

Chain	Residue
G	ARG142
G	SER146

site_id	AD1
Number of Residues	9
Details	binding site for residue B3P G 304

Chain	Residue
E	THR90
E	GLN93
E	GLY94
E	HOH408
G	GLN93
G	ASP97
G	ASP139
G	ILE143
G	HOH442

site_id	AD2
Number of Residues	13
Details	binding site for Di-peptide LYS D 185 and SEP D 186

Chain	Residue
C	LYS49
C	ARG56
C	ARG129
C	TYR130
C	LEU174
C	ASN175
C	VAL178
C	ASP225
C	ASN226
D	HIS184
D	ASP187
D	SER188
D	HOH202

site_id	AD3
Number of Residues	10
Details	binding site for Di-peptide SEP D 186 and ASP D 187

Chain	Residue
C	LYS49
C	ARG56
C	ARG129
C	TYR130
C	GLY171
C	LEU174
C	ASN175
D	LYS185
D	SER188
D	HOH202

site_id	AD4
Number of Residues	13
Details	binding site for Di-peptide LYS F 185 and SEP F 186

Chain	Residue
E	ARG56
E	ARG129
E	TYR130
E	LEU174
E	ASN175
E	VAL178
E	ASN226
F	HIS184
F	ASP187
F	SER188
F	HOH202
F	HOH203
F	HOH204

site_id	AD5
Number of Residues	13
Details	binding site for Di-peptide SEP F 186 and ASP F 187

Chain	Residue
E	ARG56
E	ARG129
E	TYR130
E	GLY171
E	LEU174
E	ASN175
F	LYS185
F	SER188
F	HOH201
F	HOH202
F	HOH203
F	HOH204
F	HOH205

site_id	AD6
Number of Residues	13
Details	binding site for Di-peptide LYS H 185 and SEP H 186

Chain	Residue
G	ARG56
G	ARG129
G	TYR130
G	LEU174
G	ASN175
G	VAL178
G	ASN226
G	HOH411
H	HIS184
H	ASP187
H	SER188
H	HOH202
H	HOH203

site_id	AD7
Number of Residues	12
Details	binding site for Di-peptide SEP H 186 and ASP H 187

Chain	Residue
H	SER188
H	HOH202
H	HOH203
G	LYS49
G	ARG56
G	ARG129
G	TYR130
G	GLY171
G	LEU174
G	ASN175
G	HOH411
H	LYS185

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG41-VAL51

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P23804

Chain	Residue	Details
B	SER190
D	SER190
F	SER190
H	SER190
E	ARG56
E	ARG129
G	ARG56
G	ARG129

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231

Chain	Residue	Details
A	SER5
C	SER5
E	SER5
G	SER5

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER74
C	SER74
E	SER74
G	SER74

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)