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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6YNH

GAPDH purified from the supernatant of HEK293F cells: crystal form 4 of 4

Functional Information from GO Data
ChainGOidnamespacecontents
B0000226biological_processmicrotubule cytoskeleton organization
B0001819biological_processpositive regulation of cytokine production
B0002376biological_processimmune system process
B0004365molecular_functionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005811cellular_componentlipid droplet
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0006006biological_processglucose metabolic process
B0006096biological_processglycolytic process
B0006417biological_processregulation of translation
B0006915biological_processapoptotic process
B0008017molecular_functionmicrotubule binding
B0010951biological_processnegative regulation of endopeptidase activity
B0015630cellular_componentmicrotubule cytoskeleton
B0016020cellular_componentmembrane
B0016241biological_processregulation of macroautophagy
B0016491molecular_functionoxidoreductase activity
B0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B0016740molecular_functiontransferase activity
B0017148biological_processnegative regulation of translation
B0019828molecular_functionaspartic-type endopeptidase inhibitor activity
B0031640biological_processkilling of cells of another organism
B0031965cellular_componentnuclear membrane
B0031982cellular_componentvesicle
B0032481biological_processpositive regulation of type I interferon production
B0035605molecular_functionpeptidyl-cysteine S-nitrosylase activity
B0035606biological_processpeptidyl-cysteine S-trans-nitrosylation
B0042802molecular_functionidentical protein binding
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0045087biological_processinnate immune response
B0048471cellular_componentperinuclear region of cytoplasm
B0050661molecular_functionNADP binding
B0050821biological_processprotein stabilization
B0050832biological_processdefense response to fungus
B0051287molecular_functionNAD binding
B0051402biological_processneuron apoptotic process
B0051873biological_processkilling by host of symbiont cells
B0061621biological_processcanonical glycolysis
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0070062cellular_componentextracellular exosome
B0071346biological_processcellular response to type II interferon
B0097452cellular_componentGAIT complex
B0097718molecular_functiondisordered domain specific binding
B1990904cellular_componentribonucleoprotein complex
D0000226biological_processmicrotubule cytoskeleton organization
D0001819biological_processpositive regulation of cytokine production
D0002376biological_processimmune system process
D0004365molecular_functionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005811cellular_componentlipid droplet
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0006006biological_processglucose metabolic process
D0006096biological_processglycolytic process
D0006417biological_processregulation of translation
D0006915biological_processapoptotic process
D0008017molecular_functionmicrotubule binding
D0010951biological_processnegative regulation of endopeptidase activity
D0015630cellular_componentmicrotubule cytoskeleton
D0016020cellular_componentmembrane
D0016241biological_processregulation of macroautophagy
D0016491molecular_functionoxidoreductase activity
D0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D0016740molecular_functiontransferase activity
D0017148biological_processnegative regulation of translation
D0019828molecular_functionaspartic-type endopeptidase inhibitor activity
D0031640biological_processkilling of cells of another organism
D0031965cellular_componentnuclear membrane
D0031982cellular_componentvesicle
D0032481biological_processpositive regulation of type I interferon production
D0035605molecular_functionpeptidyl-cysteine S-nitrosylase activity
D0035606biological_processpeptidyl-cysteine S-trans-nitrosylation
D0042802molecular_functionidentical protein binding
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0045087biological_processinnate immune response
D0048471cellular_componentperinuclear region of cytoplasm
D0050661molecular_functionNADP binding
D0050821biological_processprotein stabilization
D0050832biological_processdefense response to fungus
D0051287molecular_functionNAD binding
D0051402biological_processneuron apoptotic process
D0051873biological_processkilling by host of symbiont cells
D0061621biological_processcanonical glycolysis
D0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
D0070062cellular_componentextracellular exosome
D0071346biological_processcellular response to type II interferon
D0097452cellular_componentGAIT complex
D0097718molecular_functiondisordered domain specific binding
D1990904cellular_componentribonucleoprotein complex
F0000226biological_processmicrotubule cytoskeleton organization
F0001819biological_processpositive regulation of cytokine production
F0002376biological_processimmune system process
F0004365molecular_functionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005811cellular_componentlipid droplet
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005886cellular_componentplasma membrane
F0006006biological_processglucose metabolic process
F0006096biological_processglycolytic process
F0006417biological_processregulation of translation
F0006915biological_processapoptotic process
F0008017molecular_functionmicrotubule binding
F0010951biological_processnegative regulation of endopeptidase activity
F0015630cellular_componentmicrotubule cytoskeleton
F0016020cellular_componentmembrane
F0016241biological_processregulation of macroautophagy
F0016491molecular_functionoxidoreductase activity
F0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F0016740molecular_functiontransferase activity
F0017148biological_processnegative regulation of translation
F0019828molecular_functionaspartic-type endopeptidase inhibitor activity
F0031640biological_processkilling of cells of another organism
F0031965cellular_componentnuclear membrane
F0031982cellular_componentvesicle
F0032481biological_processpositive regulation of type I interferon production
F0035605molecular_functionpeptidyl-cysteine S-nitrosylase activity
F0035606biological_processpeptidyl-cysteine S-trans-nitrosylation
F0042802molecular_functionidentical protein binding
F0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
F0045087biological_processinnate immune response
F0048471cellular_componentperinuclear region of cytoplasm
F0050661molecular_functionNADP binding
F0050821biological_processprotein stabilization
F0050832biological_processdefense response to fungus
F0051287molecular_functionNAD binding
F0051402biological_processneuron apoptotic process
F0051873biological_processkilling by host of symbiont cells
F0061621biological_processcanonical glycolysis
F0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
F0070062cellular_componentextracellular exosome
F0071346biological_processcellular response to type II interferon
F0097452cellular_componentGAIT complex
F0097718molecular_functiondisordered domain specific binding
F1990904cellular_componentribonucleoprotein complex
G0000226biological_processmicrotubule cytoskeleton organization
G0001819biological_processpositive regulation of cytokine production
G0002376biological_processimmune system process
G0004365molecular_functionglyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005811cellular_componentlipid droplet
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0005886cellular_componentplasma membrane
G0006006biological_processglucose metabolic process
G0006096biological_processglycolytic process
G0006417biological_processregulation of translation
G0006915biological_processapoptotic process
G0008017molecular_functionmicrotubule binding
G0010951biological_processnegative regulation of endopeptidase activity
G0015630cellular_componentmicrotubule cytoskeleton
G0016020cellular_componentmembrane
G0016241biological_processregulation of macroautophagy
G0016491molecular_functionoxidoreductase activity
G0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G0016740molecular_functiontransferase activity
G0017148biological_processnegative regulation of translation
G0019828molecular_functionaspartic-type endopeptidase inhibitor activity
G0031640biological_processkilling of cells of another organism
G0031965cellular_componentnuclear membrane
G0031982cellular_componentvesicle
G0032481biological_processpositive regulation of type I interferon production
G0035605molecular_functionpeptidyl-cysteine S-nitrosylase activity
G0035606biological_processpeptidyl-cysteine S-trans-nitrosylation
G0042802molecular_functionidentical protein binding
G0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
G0045087biological_processinnate immune response
G0048471cellular_componentperinuclear region of cytoplasm
G0050661molecular_functionNADP binding
G0050821biological_processprotein stabilization
G0050832biological_processdefense response to fungus
G0051287molecular_functionNAD binding
G0051402biological_processneuron apoptotic process
G0051873biological_processkilling by host of symbiont cells
G0061621biological_processcanonical glycolysis
G0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
G0070062cellular_componentextracellular exosome
G0071346biological_processcellular response to type II interferon
G0097452cellular_componentGAIT complex
G0097718molecular_functiondisordered domain specific binding
G1990904cellular_componentribonucleoprotein complex
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue XPE B 3001
ChainResidue
BASP127
BPRO129
BMET130
BASN136
site_idAC2
Number of Residues4
Detailsbinding site for residue XPE D 3001
ChainResidue
DPRO129
DMET130
DPHE131
DASN136
site_idAC3
Number of Residues4
Detailsbinding site for residue XPE F 3001
ChainResidue
FPRO129
FMET130
FASN136
FALA128
site_idAC4
Number of Residues4
Detailsbinding site for residue XPE G 3001
ChainResidue
GPRO129
GMET130
GPHE131
GASN136
Functional Information from PROSITE/UniProt
site_idPS00071
Number of Residues8
DetailsGAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL
ChainResidueDetails
BALA150-LEU157
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues584
DetailsRegion: {"description":"Interaction with WARS1","evidences":[{"source":"PubMed","id":"15628863","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues20
DetailsMotif: {"description":"[IL]-x-C-x-x-[DE] motif","evidences":[{"source":"PubMed","id":"25417112","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"25086035","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16239728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16510976","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P22513","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsSite: {"description":"Activates thiol group during catalysis","evidences":[{"source":"PubMed","id":"16239728","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16510976","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues16
DetailsModified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"18183946","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues28
DetailsModified residue: {"description":"Deamidated asparagine","evidences":[{"source":"PubMed","id":"18183946","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsModified residue: {"description":"Methionine sulfoxide; in vitro","evidences":[{"source":"PubMed","id":"25086035","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues12
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18183946","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18183946","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsModified residue: {"description":"S-nitrosocysteine; in reversibly inhibited form","evidences":[{"source":"UniProtKB","id":"P04797","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues8
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues8
DetailsModified residue: {"description":"N6-malonyllysine; alternate","evidences":[{"source":"PubMed","id":"21908771","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18183946","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18183946","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues4
DetailsModified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"22771119","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25417112","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18183946","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues8
DetailsGlycosylation: {"description":"(Microbial infection) N-beta-linked (GlcNAc) arginine","evidences":[{"source":"PubMed","id":"28522607","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

245011

PDB entries from 2025-11-19

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