6YMW
Cryo-EM structure of yeast mitochondrial RNA polymerase transcription initiation complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001018 | molecular_function | mitochondrial promoter sequence-specific DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006269 | biological_process | DNA replication, synthesis of primer |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006390 | biological_process | mitochondrial transcription |
| A | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| A | 0034245 | cellular_component | mitochondrial DNA-directed RNA polymerase complex |
| A | 0042645 | cellular_component | mitochondrial nucleoid |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005758 | cellular_component | mitochondrial intermembrane space |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006390 | biological_process | mitochondrial transcription |
| B | 0006391 | biological_process | transcription initiation at mitochondrial promoter |
| B | 0032786 | biological_process | positive regulation of DNA-templated transcription, elongation |
| B | 0034245 | cellular_component | mitochondrial DNA-directed RNA polymerase complex |
| B | 0034246 | molecular_function | mitochondrial transcription factor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue P5E A 1401 |
| Chain | Residue |
| A | ARG829 |
| A | TYR1022 |
| A | HIS1163 |
| A | ASP1166 |
| A | ASP1189 |
| A | MG1402 |
| C | G102 |
| T | DA18 |
| A | GLY946 |
| A | THR947 |
| A | CYS948 |
| A | TYR979 |
| A | ARG1010 |
| A | LYS1014 |
| A | GLN1015 |
| A | MET1018 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 1402 |
| Chain | Residue |
| A | GLY946 |
| A | ASP1189 |
| A | P5E1401 |
Functional Information from PROSITE/UniProt
| site_id | PS00489 |
| Number of Residues | 15 |
| Details | RNA_POL_PHAGE_2 Bacteriophage-type RNA polymerase family active site signature 2. ItRkvvKqtVMTnvY |
| Chain | Residue | Details |
| A | ILE1008-TYR1022 |
| site_id | PS00900 |
| Number of Residues | 12 |
| Details | RNA_POL_PHAGE_1 Bacteriophage-type RNA polymerase family active site signature 1. PVhqDGTCNGLQ |
| Chain | Residue | Details |
| A | PRO941-GLN952 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01026","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
