6YMS

Structural and Kinetic Evaluation of Phosphoramidate Inhibitors on Thermolysin

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004222	molecular_function	metalloendopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA E 401

Chain	Residue
E	ASP138
E	GLU177
E	ASP185
E	GLU187
E	GLU190
E	HOH563

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA E 402

Chain	Residue
E	HOH568
E	HOH584
E	HOH775
E	ASP57
E	ASP59
E	GLN61

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA E 403

Chain	Residue
E	GLU177
E	ASN183
E	ASP185
E	GLU190
E	HOH561
E	HOH580

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA E 404

Chain	Residue
E	TYR193
E	THR194
E	ILE197
E	ASP200
E	HOH625
E	HOH756

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN E 405

Chain	Residue
E	HIS142
E	HIS146
E	GLU166
E	OZH409

---

site_id	AC6
Number of Residues	8
Details	binding site for residue DMS E 406

Chain	Residue
E	TYR106
E	PHE114
E	TRP115
E	ASN116
E	OZH409
E	OZH409
E	TRS410
E	HOH524

---

site_id	AC7
Number of Residues	4
Details	binding site for residue DMS E 407

Chain	Residue
E	GLY95
E	PRO184
E	TRP186
E	HOH566

---

site_id	AC8
Number of Residues	4
Details	binding site for residue DMS E 408

Chain	Residue
E	THR2
E	GLY3
E	GLN31
E	ASN33

---

site_id	AC9
Number of Residues	22
Details	binding site for residue OZH E 409

Chain	Residue
E	ASN112
E	ALA113
E	VAL139
E	HIS142
E	GLU143
E	HIS146
E	TYR157
E	GLU166
E	ILE188
E	LEU202
E	ARG203
E	ASP226
E	HIS231
E	ZN405
E	DMS406
E	DMS406
E	TRS410
E	HOH526
E	HOH535
E	HOH553
E	HOH770
E	HOH804

---

site_id	AD1
Number of Residues	9
Details	binding site for residue TRS E 410

Chain	Residue
E	TRP115
E	HIS146
E	ASP150
E	TYR157
E	ASN165
E	DMS406
E	OZH409
E	HOH524
E	HOH659

---

site_id	AD2
Number of Residues	5
Details	binding site for residue GOL E 411

Chain	Residue
E	GLY109
E	TYR110
E	ASN111
E	ASN112
E	HOH613

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV

Chain	Residue	Details
E	VAL139-VAL148

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---