6YM2

Crystal structure of YTHDC1 with compound ADO_AC_25

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
B	0003723	molecular_function	RNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue OYK A 601

Chain	Residue
A	LYS361
A	SO4604
A	HOH759
A	SER362
A	ASN363
A	ASN367
A	TRP377
A	SER378
A	TRP428
A	PRO431
A	ASP476

---

site_id	AC2
Number of Residues	8
Details	binding site for residue SO4 A 602

Chain	Residue
A	GLY344
A	THR345
A	SER346
A	LYS347
A	HOH718
A	HOH742
A	HOH781
B	GLU479

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 603

Chain	Residue
A	HIS420
A	HIS421
A	HOH701

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 604

Chain	Residue
A	ARG404
A	ARG475
A	ASP476
A	OYK601
A	HOH705
A	HOH716

---

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 A 605

Chain	Residue
A	GLN478
A	GLU479

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 606

Chain	Residue
A	ASN363
A	PRO431
A	ALA432
A	HOH702

---

site_id	AC7
Number of Residues	10
Details	binding site for residue OYK B 601

Chain	Residue
B	LYS361
B	SER362
B	ASN363
B	ASN367
B	TRP377
B	SER378
B	TRP428
B	PRO431
B	ASP476
B	HOH773

---

site_id	AC8
Number of Residues	8
Details	binding site for residue SO4 B 602

Chain	Residue
A	SER424
B	ARG404
B	ARG475
B	ASP476
B	HOH726
B	HOH743
B	HOH758
B	HOH767

---

site_id	AC9
Number of Residues	6
Details	binding site for residue SO4 B 603

Chain	Residue
B	ARG451
B	GLU452
B	HOH734
B	HOH739
B	HOH769
B	HOH792

---

site_id	AD1
Number of Residues	8
Details	binding site for residue SO4 B 604

Chain	Residue
A	GLY423
B	LYS361
B	ILE473
B	GLY474
B	HOH721
B	HOH729
B	HOH761
B	HOH774

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 B 605

Chain	Residue
B	SER419
B	HIS420
B	HIS421
B	ARG451

---

site_id	AD3
Number of Residues	5
Details	binding site for residue SO4 B 606

Chain	Residue
B	GLU405
B	HOH712
B	HOH721
B	HOH772
B	HOH780

---

site_id	AD4
Number of Residues	5
Details	binding site for residue SO4 B 607

Chain	Residue
B	LYS385
B	ASN388
B	ARG392
B	LYS457
B	HOH791

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	274
Details	Domain: {"description":"YTH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00225","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---