6YL0

Crystal structure of YTHDC1 with compound T_96

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
B	0003723	molecular_function	RNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue OWH A 601

Chain	Residue
A	ASN367
A	SER378
A	THR379
A	LEU380
A	TRP428
A	MET434
A	ASP476
A	HOH754

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 602

Chain	Residue
A	PRO431
A	ALA432
A	HOH734
A	HOH851
B	HIS505
A	ASN363

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 603

Chain	Residue
A	HIS420
A	HIS421
A	HOH704

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 604

Chain	Residue
A	GLY344
A	THR345
A	SER346
A	LYS347
A	HOH725

---

site_id	AC5
Number of Residues	7
Details	binding site for residue SO4 A 605

Chain	Residue
A	ARG404
A	ARG475
A	ASP476
A	HOH740
A	HOH819
A	HOH840
A	HOH866

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 B 601

Chain	Residue
B	ARG451
B	GLU452
B	HOH756
B	HOH759
B	HOH766
B	HOH792
B	HOH794

---

site_id	AC7
Number of Residues	11
Details	binding site for residue PEG B 602

Chain	Residue
B	GLU384
B	LYS385
B	ASN388
B	LYS457
B	HOH701
B	HOH708
B	HOH712
B	HOH713
B	HOH777
B	HOH837
B	HOH874

---

site_id	AC8
Number of Residues	9
Details	binding site for residue OWH B 603

Chain	Residue
B	ASN367
B	SER378
B	THR379
B	LEU380
B	TRP428
B	ASP476
B	HOH704
B	HOH806
B	HOH843

---

site_id	AC9
Number of Residues	11
Details	binding site for residue SO4 B 604

Chain	Residue
A	TRP465
A	GLN478
A	GLU479
A	HOH776
B	GLY344
B	LYS347
B	HOH724
B	HOH727
B	HOH846
B	HOH852
B	HOH861

---

site_id	AD1
Number of Residues	8
Details	binding site for residue SO4 B 605

Chain	Residue
B	SER419
B	HIS420
B	HIS421
B	ARG451
B	HOH705
B	HOH807
B	HOH881
B	HOH886

---

site_id	AD2
Number of Residues	6
Details	binding site for residue SO4 B 606

Chain	Residue
B	LYS361
B	ARG404
B	ARG475
B	ASP476
B	HOH740
B	HOH812

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	274
Details	Domain: {"description":"YTH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00225","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---