6YK6

Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)furo[3,4-d]pyrimidin-2,4-dione at resolution 1.47A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SO4 A 301

Chain	Residue
A	LYS60
A	ASN72
A	SER140
A	HOH401
A	HOH414
A	HOH421
A	HOH500
A	HOH577

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 302

Chain	Residue
A	LYS240
A	GLN244
A	HOH452
A	HOH608
A	HIS46

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 303

Chain	Residue
A	MET18
A	MET19
A	HOH415
A	HOH484
A	HOH552

---

site_id	AC4
Number of Residues	2
Details	binding site for residue SO4 A 304

Chain	Residue
A	LYS82
A	LYS116

---

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL A 305

Chain	Residue
A	LYS116
A	LYS185
A	GLY186
A	HOH553

---

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL A 306

Chain	Residue
A	LYS117
A	GLU201
A	GLN202
A	CYS206
A	HOH449

---

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL A 307

Chain	Residue
A	ASN214
A	ASP216
A	SER217
A	ASP248
A	HOH481

---

site_id	AC8
Number of Residues	4
Details	binding site for residue LI A 308

Chain	Residue
A	GLU97
A	ILE100
A	ASP101
A	HOH509

---

site_id	AC9
Number of Residues	1
Details	binding site for residue CL A 309

Chain	Residue
A	THR5

---

site_id	AD1
Number of Residues	1
Details	binding site for residue CL A 310

Chain	Residue
A	ALA153

---

site_id	AD2
Number of Residues	16
Details	binding site for residue OUB A 311

Chain	Residue
A	GLU13
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143
A	LEU192
A	GLU193
A	TYR220
A	HOH416
A	HOH480
A	HOH495

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3

---