6YK6
Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)furo[3,4-d]pyrimidin-2,4-dione at resolution 1.47A
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | LYS60 |
| A | ASN72 |
| A | SER140 |
| A | HOH401 |
| A | HOH414 |
| A | HOH421 |
| A | HOH500 |
| A | HOH577 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | LYS240 |
| A | GLN244 |
| A | HOH452 |
| A | HOH608 |
| A | HIS46 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | MET18 |
| A | MET19 |
| A | HOH415 |
| A | HOH484 |
| A | HOH552 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 304 |
| Chain | Residue |
| A | LYS82 |
| A | LYS116 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | LYS116 |
| A | LYS185 |
| A | GLY186 |
| A | HOH553 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | LYS117 |
| A | GLU201 |
| A | GLN202 |
| A | CYS206 |
| A | HOH449 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 307 |
| Chain | Residue |
| A | ASN214 |
| A | ASP216 |
| A | SER217 |
| A | ASP248 |
| A | HOH481 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue LI A 308 |
| Chain | Residue |
| A | GLU97 |
| A | ILE100 |
| A | ASP101 |
| A | HOH509 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 309 |
| Chain | Residue |
| A | THR5 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 310 |
| Chain | Residue |
| A | ALA153 |
| site_id | AD2 |
| Number of Residues | 16 |
| Details | binding site for residue OUB A 311 |
| Chain | Residue |
| A | GLU13 |
| A | TYR61 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | LEU138 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | LEU192 |
| A | GLU193 |
| A | TYR220 |
| A | HOH416 |
| A | HOH480 |
| A | HOH495 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
