6YK3
Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound ( S) - 1- [2'-Amino-2'-carboxyethyl]-5 ,7- dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 1.20A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | TRP71 |
| A | VAL79 |
| A | GLY118 |
| A | PRO120 |
| A | HOH469 |
| A | HOH474 |
| A | HOH590 |
| A | HOH597 |
| A | HOH660 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | ASN214 |
| A | ASP216 |
| A | SER217 |
| A | ASP248 |
| A | HOH461 |
| A | HOH680 |
| A | HOH783 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | GLU13 |
| A | TYR61 |
| A | THR173 |
| A | THR174 |
| A | HOH403 |
| A | HOH547 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | LYS117 |
| A | GLU201 |
| A | GLN202 |
| A | HOH432 |
| A | HOH634 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | LYS82 |
| A | LYS116 |
| A | ARG182 |
| A | HOH438 |
| A | HOH517 |
| A | HOH613 |
| A | HOH689 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 306 |
| Chain | Residue |
| A | LYS60 |
| A | ALA63 |
| A | ASN72 |
| A | SER140 |
| A | HOH407 |
| A | HOH439 |
| A | HOH518 |
| A | HOH671 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 307 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 308 |
| Chain | Residue |
| A | ILE152 |
| A | ALA153 |
| A | LYS249 |
| A | HOH419 |
| A | HOH690 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | binding site for residue PVQ A 309 |
| Chain | Residue |
| A | GLU13 |
| A | TYR61 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | LEU138 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | LEU192 |
| A | GLU193 |
| A | TYR220 |
| A | HOH506 |
| A | HOH523 |
| A | HOH585 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue NH4 A 310 |
| Chain | Residue |
| A | GLU97 |
| A | ILE100 |
| A | ASP101 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 311 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 312 |
| Chain | Residue |
| A | MET18 |
| A | MET19 |
| A | HOH594 |
| A | HOH817 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | PRO89 | |
| A | THR91 | |
| A | ARG96 | |
| A | SER142 | |
| A | THR143 | |
| A | GLU193 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ARG64 | |
| A | ARG148 | |
| A | LYS240 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ILE121 | |
| Chain | Residue | Details |
| A | SER150 | |
| Chain | Residue | Details |
| A | SER184 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
