6YJH

Crystal structure of Imidazole Glycerol Phosphate Dehydratase from Mycobacterium tuberculosis at 1.61 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000105	biological_process	L-histidine biosynthetic process
A	0003824	molecular_function	catalytic activity
A	0004424	molecular_function	imidazoleglycerol-phosphate dehydratase activity
A	0005737	cellular_component	cytoplasm
A	0008652	biological_process	amino acid biosynthetic process
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MN A 301

Chain	Residue
A	HIS73
A	GLU77
A	HIS152
A	HIS177
A	HOH431
A	HOH480

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MN A 302

Chain	Residue
A	GLU180
A	HOH429
A	HOH484
A	HIS47
A	HIS74
A	HIS176

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MN A 303

Chain	Residue
A	ARG168
A	ARG168
A	ARG168

---

Functional Information from PROSITE/UniProt

site_id	PS00954
Number of Residues	14
Details	IGP_DEHYDRATASE_1 Imidazoleglycerol-phosphate dehydratase signature 1. IEaHHtiEdtAIAL

Chain	Residue	Details
A	ILE70-LEU83

---

site_id	PS00955
Number of Residues	13
Details	IGP_DEHYDRATASE_2 Imidazoleglycerol-phosphate dehydratase signature 2. GrDpHHitEAqYK

Chain	Residue	Details
A	GLY172-LYS184

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O23346","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24311587","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24311587","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GQU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24311587","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XDS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---