6YJ2
Structural and DNA binding studies of the transcriptional repressor Rv2506 (BkaR) from Mycobacterium tuberculosis supports a role in L-Leucine catabolism
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0042783 | biological_process | evasion of host immune response |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0042783 | biological_process | evasion of host immune response |
| B | 0042802 | molecular_function | identical protein binding |
| C | 0000976 | molecular_function | transcription cis-regulatory region binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0042783 | biological_process | evasion of host immune response |
| C | 0042802 | molecular_function | identical protein binding |
| D | 0000976 | molecular_function | transcription cis-regulatory region binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0042783 | biological_process | evasion of host immune response |
| D | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 301 |
| Chain | Residue |
| B | HIS109 |
| B | GLN123 |
| B | GLN142 |
| B | ASN177 |
| B | HOH417 |
| B | HOH419 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| B | GLU116 |
| B | HOH431 |
| B | ARG83 |
| B | LEU84 |
| B | PHE108 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 303 |
| Chain | Residue |
| B | ILE120 |
| B | ARG121 |
| B | ASP124 |
| B | ASN177 |
| B | PRO180 |
| B | HIS181 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 301 |
| Chain | Residue |
| D | ARG83 |
| D | PHE108 |
| D | GLU116 |
| D | HOH451 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 302 |
| Chain | Residue |
| C | SER178 |
| C | HIS181 |
| C | HOH422 |
| D | HIS170 |
| D | ASN177 |
| D | HOH410 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | ARG83 |
| A | PHE108 |
| A | PHE112 |
| A | GLU116 |
| A | HOH402 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 301 |
| Chain | Residue |
| C | VAL194 |
| C | ARG195 |
| C | ALA198 |
| D | GLU147 |
| D | HOH417 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 302 |
| Chain | Residue |
| C | GLU107 |
| C | ASP111 |
| C | ARG197 |
| C | HOH405 |
| C | HOH426 |
| C | HOH431 |
| D | ARG154 |
| D | PRO158 |
| D | GLY159 |
