6YEV

Crystal structure of MsrA C206 and Trx C35S complex from Escherichia coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0008113	molecular_function	peptide-methionine (S)-S-oxide reductase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016671	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
A	0030091	biological_process	protein repair
A	0033744	molecular_function	L-methionine (S)-S-oxide reductase activity
A	0034599	biological_process	cellular response to oxidative stress
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0008113	molecular_function	peptide-methionine (S)-S-oxide reductase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016671	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
B	0030091	biological_process	protein repair
B	0033744	molecular_function	L-methionine (S)-S-oxide reductase activity
B	0034599	biological_process	cellular response to oxidative stress
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0008113	molecular_function	peptide-methionine (S)-S-oxide reductase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016671	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
C	0030091	biological_process	protein repair
C	0033744	molecular_function	L-methionine (S)-S-oxide reductase activity
C	0034599	biological_process	cellular response to oxidative stress
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0008113	molecular_function	peptide-methionine (S)-S-oxide reductase activity
D	0016491	molecular_function	oxidoreductase activity
D	0016671	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
D	0030091	biological_process	protein repair
D	0033744	molecular_function	L-methionine (S)-S-oxide reductase activity
D	0034599	biological_process	cellular response to oxidative stress
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0015035	molecular_function	protein-disulfide reductase activity
E	0030337	molecular_function	DNA polymerase processivity factor activity
E	0045454	biological_process	cell redox homeostasis
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0015035	molecular_function	protein-disulfide reductase activity
F	0030337	molecular_function	DNA polymerase processivity factor activity
F	0045454	biological_process	cell redox homeostasis
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0015035	molecular_function	protein-disulfide reductase activity
G	0030337	molecular_function	DNA polymerase processivity factor activity
G	0045454	biological_process	cell redox homeostasis

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue NA A 301

Chain	Residue
A	TYR82
A	GLU94
A	TYR134

---

site_id	AC2
Number of Residues	2
Details	binding site for residue NA B 301

Chain	Residue
B	TYR82
B	GLU94

---

site_id	AC3
Number of Residues	3
Details	binding site for residue NA C 301

Chain	Residue
C	PHE52
C	TYR82
C	GLU94

---

site_id	AC4
Number of Residues	2
Details	binding site for residue NA D 301

Chain	Residue
D	GLU94
D	TYR82

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Nucleophile"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Site: {"description":"Deprotonates C-terminal active site Cys"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Site: {"description":"Contributes to redox potential value"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	107
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"10964927","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---