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6YEV

Crystal structure of MsrA C206 and Trx C35S complex from Escherichia coli

Functional Information from GO Data
ChainGOidnamespacecontents
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006979biological_processresponse to oxidative stress
A0008113molecular_functionpeptide-methionine (S)-S-oxide reductase activity
A0016491molecular_functionoxidoreductase activity
A0016671molecular_functionoxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
A0030091biological_processprotein repair
A0033744molecular_functionL-methionine:thioredoxin-disulfide S-oxidoreductase activity
A0034599biological_processcellular response to oxidative stress
A0036211biological_processprotein modification process
A0036456molecular_functionL-methionine-(S)-S-oxide reductase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006979biological_processresponse to oxidative stress
B0008113molecular_functionpeptide-methionine (S)-S-oxide reductase activity
B0016491molecular_functionoxidoreductase activity
B0016671molecular_functionoxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
B0030091biological_processprotein repair
B0033744molecular_functionL-methionine:thioredoxin-disulfide S-oxidoreductase activity
B0034599biological_processcellular response to oxidative stress
B0036211biological_processprotein modification process
B0036456molecular_functionL-methionine-(S)-S-oxide reductase activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006979biological_processresponse to oxidative stress
C0008113molecular_functionpeptide-methionine (S)-S-oxide reductase activity
C0016491molecular_functionoxidoreductase activity
C0016671molecular_functionoxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
C0030091biological_processprotein repair
C0033744molecular_functionL-methionine:thioredoxin-disulfide S-oxidoreductase activity
C0034599biological_processcellular response to oxidative stress
C0036211biological_processprotein modification process
C0036456molecular_functionL-methionine-(S)-S-oxide reductase activity
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006979biological_processresponse to oxidative stress
D0008113molecular_functionpeptide-methionine (S)-S-oxide reductase activity
D0016491molecular_functionoxidoreductase activity
D0016671molecular_functionoxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
D0030091biological_processprotein repair
D0033744molecular_functionL-methionine:thioredoxin-disulfide S-oxidoreductase activity
D0034599biological_processcellular response to oxidative stress
D0036211biological_processprotein modification process
D0036456molecular_functionL-methionine-(S)-S-oxide reductase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0015035molecular_functionprotein-disulfide reductase activity
E0015036molecular_functiondisulfide oxidoreductase activity
E0030337molecular_functionDNA polymerase processivity factor activity
E0045454biological_processcell redox homeostasis
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0015035molecular_functionprotein-disulfide reductase activity
F0015036molecular_functiondisulfide oxidoreductase activity
F0030337molecular_functionDNA polymerase processivity factor activity
F0045454biological_processcell redox homeostasis
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0015035molecular_functionprotein-disulfide reductase activity
G0015036molecular_functiondisulfide oxidoreductase activity
G0030337molecular_functionDNA polymerase processivity factor activity
G0045454biological_processcell redox homeostasis
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue NA A 301
ChainResidue
ATYR82
AGLU94
ATYR134

site_idAC2
Number of Residues2
Detailsbinding site for residue NA B 301
ChainResidue
BTYR82
BGLU94

site_idAC3
Number of Residues3
Detailsbinding site for residue NA C 301
ChainResidue
CPHE52
CTYR82
CGLU94

site_idAC4
Number of Residues2
Detailsbinding site for residue NA D 301
ChainResidue
DGLU94
DTYR82

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000269|PubMed:10964927
ChainResidueDetails
AALA51
BALA51
CALA51
DALA51
GCYS32
GSER35

site_idSWS_FT_FI2
Number of Residues3
DetailsSITE: Deprotonates C-terminal active site Cys
ChainResidueDetails
EASP26
FASP26
GASP26

site_idSWS_FT_FI3
Number of Residues6
DetailsSITE: Contributes to redox potential value
ChainResidueDetails
EGLY33
EPRO34
FGLY33
FPRO34
GGLY33
GPRO34

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842
ChainResidueDetails
ELYS69
FLYS69
GLYS69

224931

PDB entries from 2024-09-11

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