6YBT

Structure of a human 48S translational initiation complex - eIF3bgi

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0001732	biological_process	formation of cytoplasmic translation initiation complex
1	0002183	biological_process	cytoplasmic translational initiation
1	0003676	molecular_function	nucleic acid binding
1	0003723	molecular_function	RNA binding
1	0003743	molecular_function	translation initiation factor activity
1	0005515	molecular_function	protein binding
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
1	0006412	biological_process	translation
1	0006413	biological_process	translational initiation
1	0006446	biological_process	regulation of translational initiation
1	0010494	cellular_component	cytoplasmic stress granule
1	0016282	cellular_component	eukaryotic 43S preinitiation complex
1	0031369	molecular_function	translation initiation factor binding
1	0033290	cellular_component	eukaryotic 48S preinitiation complex
1	0045202	cellular_component	synapse
1	0060090	molecular_function	molecular adaptor activity
1	0070062	cellular_component	extracellular exosome
1	0071541	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3m
1	0075522	biological_process	IRES-dependent viral translational initiation
1	0075525	biological_process	viral translational termination-reinitiation
2	0001732	biological_process	formation of cytoplasmic translation initiation complex
2	0002183	biological_process	cytoplasmic translational initiation
2	0003723	molecular_function	RNA binding
2	0003743	molecular_function	translation initiation factor activity
2	0005515	molecular_function	protein binding
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
2	0006412	biological_process	translation
2	0006413	biological_process	translational initiation
2	0016282	cellular_component	eukaryotic 43S preinitiation complex
2	0033290	cellular_component	eukaryotic 48S preinitiation complex
2	0045202	cellular_component	synapse
2	0070062	cellular_component	extracellular exosome
2	0071541	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3m
u	0001732	biological_process	formation of cytoplasmic translation initiation complex
u	0002183	biological_process	cytoplasmic translational initiation
u	0002188	biological_process	translation reinitiation
u	0003723	molecular_function	RNA binding
u	0003729	molecular_function	mRNA binding
u	0003743	molecular_function	translation initiation factor activity
u	0005198	molecular_function	structural molecule activity
u	0005515	molecular_function	protein binding
u	0005654	cellular_component	nucleoplasm
u	0005730	cellular_component	nucleolus
u	0005737	cellular_component	cytoplasm
u	0005829	cellular_component	cytosol
u	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
u	0005874	cellular_component	microtubule
u	0006412	biological_process	translation
u	0006413	biological_process	translational initiation
u	0014069	cellular_component	postsynaptic density
u	0016020	cellular_component	membrane
u	0016282	cellular_component	eukaryotic 43S preinitiation complex
u	0030971	molecular_function	receptor tyrosine kinase binding
u	0032991	cellular_component	protein-containing complex
u	0033290	cellular_component	eukaryotic 48S preinitiation complex
u	0043614	cellular_component	multi-eIF complex
u	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
u	0071540	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3e
u	0071541	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3m
u	0075522	biological_process	IRES-dependent viral translational initiation
u	0075525	biological_process	viral translational termination-reinitiation

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VLTGsaDnSCRLWDC

Chain	Residue	Details
2	VAL67-CYS81

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17322308, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
1	MET1

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
1	SER78
1	SER81

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17322308, ECO:0007744|PubMed:18669648

Chain	Residue	Details
1	SER83
1	SER85
u	SER949
u	SER1028
u	SER1188
u	SER1262

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17322308

Chain	Residue	Details
1	SER119
u	SER1198
u	SER1336

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17322308, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569

Chain	Residue	Details
1	SER125

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17322308, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231

Chain	Residue	Details
1	SER152
1	SER164

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000255|HAMAP-Rule:MF_03001, ECO:0000269|PubMed:17322308, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
1	SER154

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site_id	SWS_FT_FI8
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
1	LYS209
1	LYS288
1	LYS364

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site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
1	SER239

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