Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6YBT

Structure of a human 48S translational initiation complex - eIF3bgi

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0001732	biological_process	formation of cytoplasmic translation initiation complex
1	0002183	biological_process	cytoplasmic translational initiation
1	0003676	molecular_function	nucleic acid binding
1	0003723	molecular_function	RNA binding
1	0003743	molecular_function	translation initiation factor activity
1	0005515	molecular_function	protein binding
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
1	0006412	biological_process	translation
1	0006413	biological_process	translational initiation
1	0006446	biological_process	regulation of translational initiation
1	0010494	cellular_component	cytoplasmic stress granule
1	0016282	cellular_component	eukaryotic 43S preinitiation complex
1	0031369	molecular_function	translation initiation factor binding
1	0033290	cellular_component	eukaryotic 48S preinitiation complex
1	0045202	cellular_component	synapse
1	0060090	molecular_function	molecular adaptor activity
1	0070062	cellular_component	extracellular exosome
1	0071541	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3m
1	0075522	biological_process	IRES-dependent viral translational initiation
1	0075525	biological_process	viral translational termination-reinitiation
2	0001732	biological_process	formation of cytoplasmic translation initiation complex
2	0002183	biological_process	cytoplasmic translational initiation
2	0003723	molecular_function	RNA binding
2	0003743	molecular_function	translation initiation factor activity
2	0005515	molecular_function	protein binding
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
2	0006412	biological_process	translation
2	0006413	biological_process	translational initiation
2	0016282	cellular_component	eukaryotic 43S preinitiation complex
2	0033290	cellular_component	eukaryotic 48S preinitiation complex
2	0045202	cellular_component	synapse
2	0070062	cellular_component	extracellular exosome
2	0071541	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3m
u	0001732	biological_process	formation of cytoplasmic translation initiation complex
u	0002183	biological_process	cytoplasmic translational initiation
u	0002188	biological_process	translation reinitiation
u	0003723	molecular_function	RNA binding
u	0003729	molecular_function	mRNA binding
u	0003743	molecular_function	translation initiation factor activity
u	0005198	molecular_function	structural molecule activity
u	0005515	molecular_function	protein binding
u	0005737	cellular_component	cytoplasm
u	0005829	cellular_component	cytosol
u	0005852	cellular_component	eukaryotic translation initiation factor 3 complex
u	0005874	cellular_component	microtubule
u	0006412	biological_process	translation
u	0006413	biological_process	translational initiation
u	0014069	cellular_component	postsynaptic density
u	0016020	cellular_component	membrane
u	0016282	cellular_component	eukaryotic 43S preinitiation complex
u	0030971	molecular_function	receptor tyrosine kinase binding
u	0032991	cellular_component	protein-containing complex
u	0033290	cellular_component	eukaryotic 48S preinitiation complex
u	0043226	cellular_component	organelle
u	0043614	cellular_component	multi-eIF complex
u	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
u	0071540	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3e
u	0071541	cellular_component	eukaryotic translation initiation factor 3 complex, eIF3m
u	0075522	biological_process	IRES-dependent viral translational initiation
u	0075525	biological_process	viral translational termination-reinitiation

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VLTGsaDnSCRLWDC

Chain	Residue	Details
2	VAL67-CYS81

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	77
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	78
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	103
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	37
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	90
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	83
Details	Domain: {"description":"RRM","evidences":[{"source":"HAMAP-Rule","id":"MF_03001","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	59
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	43
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	42
Details	Repeat: {"description":"WD 8"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	104
Details	Region: {"description":"Sufficient for interaction with EIF3J"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)