6Y88

IGPS (Indole-3-glycerol phosphate synthase) from Pseudomonas aeruginosa in complex with substrate inhibitor rCdRP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000162	biological_process	L-tryptophan biosynthetic process
A	0004425	molecular_function	indole-3-glycerol-phosphate synthase activity
A	0006568	biological_process	L-tryptophan metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
B	0000162	biological_process	L-tryptophan biosynthetic process
B	0004425	molecular_function	indole-3-glycerol-phosphate synthase activity
B	0006568	biological_process	L-tryptophan metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
C	0000162	biological_process	L-tryptophan biosynthetic process
C	0004425	molecular_function	indole-3-glycerol-phosphate synthase activity
C	0006568	biological_process	L-tryptophan metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016831	molecular_function	carboxy-lyase activity
D	0000162	biological_process	L-tryptophan biosynthetic process
D	0004425	molecular_function	indole-3-glycerol-phosphate synthase activity
D	0006568	biological_process	L-tryptophan metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016831	molecular_function	carboxy-lyase activity
E	0000162	biological_process	L-tryptophan biosynthetic process
E	0004425	molecular_function	indole-3-glycerol-phosphate synthase activity
E	0006568	biological_process	L-tryptophan metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0009073	biological_process	aromatic amino acid family biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016831	molecular_function	carboxy-lyase activity
F	0000162	biological_process	L-tryptophan biosynthetic process
F	0004425	molecular_function	indole-3-glycerol-phosphate synthase activity
F	0006568	biological_process	L-tryptophan metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0009073	biological_process	aromatic amino acid family biosynthetic process
F	0016829	molecular_function	lyase activity
F	0016831	molecular_function	carboxy-lyase activity
G	0000162	biological_process	L-tryptophan biosynthetic process
G	0004425	molecular_function	indole-3-glycerol-phosphate synthase activity
G	0006568	biological_process	L-tryptophan metabolic process
G	0008652	biological_process	amino acid biosynthetic process
G	0009073	biological_process	aromatic amino acid family biosynthetic process
G	0016829	molecular_function	lyase activity
G	0016831	molecular_function	carboxy-lyase activity
H	0000162	biological_process	L-tryptophan biosynthetic process
H	0004425	molecular_function	indole-3-glycerol-phosphate synthase activity
H	0006568	biological_process	L-tryptophan metabolic process
H	0008652	biological_process	amino acid biosynthetic process
H	0009073	biological_process	aromatic amino acid family biosynthetic process
H	0016829	molecular_function	lyase activity
H	0016831	molecular_function	carboxy-lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue 137 A 301

Chain	Residue
A	GLU61
A	GLY226
A	LEU245
A	VAL246
A	GLY247
A	GLU248
A	HOH405
A	HOH411
A	HOH434
A	HOH436
A	HOH438
A	LYS63
A	HOH446
A	HOH467
A	SER66
A	SER68
A	PHE102
A	LYS123
A	ARG196
A	GLU224
A	SER225

---

site_id	AC2
Number of Residues	4
Details	binding site for residue GOL A 302

Chain	Residue
A	ASP38
A	ALA39
A	ARG41
A	ARG113

---

site_id	AC3
Number of Residues	20
Details	binding site for residue 137 B 301

Chain	Residue
B	GLU61
B	LYS63
B	SER66
B	SER68
B	PHE102
B	LYS123
B	ARG196
B	LEU198
B	SER225
B	GLY226
B	LEU245
B	VAL246
B	GLY247
B	GLU248
B	HOH424
B	HOH435
B	HOH438
B	HOH439
B	HOH443
B	HOH478

---

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL B 302

Chain	Residue
B	SER66
B	PRO67
B	ASP100
B	PHE101

---

site_id	AC5
Number of Residues	4
Details	binding site for residue GOL B 303

Chain	Residue
B	ASP106
B	LYS110
B	HOH407
B	HOH444

---

site_id	AC6
Number of Residues	19
Details	binding site for residue 137 C 301

Chain	Residue
C	GLU61
C	LYS63
C	SER66
C	SER68
C	PHE102
C	LYS123
C	GLU224
C	SER225
C	GLY226
C	LEU245
C	VAL246
C	GLY247
C	GLU248
C	HOH405
C	HOH418
C	HOH422
C	HOH425
C	HOH431
C	HOH448

---

site_id	AC7
Number of Residues	8
Details	binding site for residue GOL C 302

Chain	Residue
C	LYS14
C	ARG21
C	THR97
C	ARG122
C	ASP124
C	GLN131
C	GLU134
C	HOH483

---

site_id	AC8
Number of Residues	2
Details	binding site for residue GOL C 303

Chain	Residue
C	ASP168
C	HOH402

---

site_id	AC9
Number of Residues	17
Details	binding site for residue 137 D 301

Chain	Residue
D	GLU61
D	LYS63
D	PRO67
D	SER68
D	LYS123
D	LEU198
D	GLU224
D	SER225
D	GLY226
D	LEU245
D	GLY247
D	GLU248
D	HOH403
D	HOH411
D	HOH426
D	HOH442
D	HOH448

---

site_id	AD1
Number of Residues	21
Details	binding site for residue 137 E 301

Chain	Residue
E	GLU61
E	LYS63
E	SER66
E	PRO67
E	SER68
E	PHE102
E	LYS123
E	ARG196
E	LEU198
E	GLU224
E	SER225
E	GLY226
E	LEU245
E	VAL246
E	GLY247
E	GLU248
E	HOH411
E	HOH415
E	HOH438
E	HOH447
E	HOH451

---

site_id	AD2
Number of Residues	8
Details	binding site for residue CIT E 302

Chain	Residue
A	HOH427
E	GLU17
E	GLU20
E	ARG21
E	ARG24
E	VAL99
E	HOH404
E	HOH440

---

site_id	AD3
Number of Residues	6
Details	binding site for residue GOL E 303

Chain	Residue
E	ARG73
E	HIS75
E	PHE76
E	VAL77
E	GLU80
E	ILE81

---

site_id	AD4
Number of Residues	17
Details	binding site for residue 137 F 301

Chain	Residue
F	GLU61
F	LYS63
F	SER66
F	SER68
F	LYS123
F	ARG196
F	LEU198
F	GLU224
F	SER225
F	GLY226
F	GLY247
F	GLU248
F	HOH407
F	HOH416
F	HOH429
F	HOH431
F	HOH463

---

site_id	AD5
Number of Residues	7
Details	binding site for residue PO4 G 301

Chain	Residue
G	LYS63
G	ARG196
G	SER225
G	GLY247
G	GLU248
G	HOH415
G	HOH425

---

site_id	AD6
Number of Residues	18
Details	binding site for residue 137 H 301

Chain	Residue
H	GLU61
H	LYS63
H	SER66
H	PRO67
H	SER68
H	LYS123
H	ARG196
H	GLU224
H	SER225
H	LEU245
H	VAL246
H	GLY247
H	GLU248
H	HOH415
H	HOH416
H	HOH419
H	HOH436
H	HOH450

---

site_id	AD7
Number of Residues	8
Details	binding site for residue GOL H 302

Chain	Residue
H	LYS14
H	GLU17
H	THR97
H	ARG122
H	ASP124
H	GLN131
H	GLU134
H	HOH451

---

Functional Information from PROSITE/UniProt

site_id	PS00614
Number of Residues	19
Details	IGPS Indole-3-glycerol phosphate synthase signature. VIaEIKKASPSkgvlrehF

Chain	Residue	Details
A	VAL58-PHE76
G	VAL58-PHE76

---