6Y6L

Structure the ananain protease from Ananas comosus with a thiomethylated catalytic cysteine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 301

Chain	Residue
A	SER198
A	HOH402
A	HOH409
A	HOH533
A	HOH584

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 302

Chain	Residue
A	HOH414
A	HOH509
B	LYS41
A	LYS39
A	GLY43
A	ASN44
A	LEU45

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 303

Chain	Residue
A	ASN68
A	LYS69
A	HOH412
A	HOH421
A	HOH488

---

site_id	AC4
Number of Residues	7
Details	binding site for residue GOL A 304

Chain	Residue
A	LYS17
A	ASN18
A	GLU50
A	HOH462
A	HOH465
A	HOH490
A	HOH532

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL A 305

Chain	Residue
A	ASP195
A	VAL196
A	SER197
A	HOH533
A	HOH600

---

site_id	AC6
Number of Residues	8
Details	binding site for residue GOL A 306

Chain	Residue
A	ASN18
A	ASN119
A	TYR122
A	GLY181
A	ALA182
A	GLY183
A	HOH401
A	HOH597

---

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 B 301

Chain	Residue
A	LYS41
B	LYS39
B	GLY43
B	ASN44
B	LEU45
B	HOH491

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 B 302

Chain	Residue
B	ARG114
B	HOH403
B	HOH407
B	HOH543

---

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 B 303

Chain	Residue
B	LYS89
B	GLY93
B	THR94

---

site_id	AD1
Number of Residues	7
Details	binding site for residue GOL B 304

Chain	Residue
B	LYS17
B	ASN18
B	GLU50
B	HOH422
B	HOH431
B	HOH449
B	HOH496

---

site_id	AD2
Number of Residues	9
Details	binding site for residue GOL B 305

Chain	Residue
B	ASN18
B	ASN119
B	TYR122
B	TRP180
B	GLY181
B	ALA182
B	GLY183
B	HOH410
B	HOH411

---

site_id	AD3
Number of Residues	9
Details	binding site for residue GOL B 306

Chain	Residue
B	SCH25
B	TRP26
B	GLY65
B	TRP66
B	ILE67
B	HIS157
B	ALA158
B	HOH517
B	HOH551

---

Functional Information from PROSITE/UniProt

site_id	PS00139
Number of Residues	12
Details	THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGrCGSCWAfAS

Chain	Residue	Details
A	GLN19-SER30

---

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAIVIIGYG

Chain	Residue	Details
A	LEU155-GLY165

---

site_id	PS00640
Number of Residues	20
Details	THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. FWIvRNSWgagWGegGYIrL

Chain	Residue	Details
A	PHE173-LEU192

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10088","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31306685","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10089","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31306685","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10090","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"31306685","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6MIS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6YCC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---