6Y5R
Structure of Human Potassium Chloride Transporter KCC3 S45D/T940D/T997D in NaCl
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006884 | biological_process | cell volume homeostasis |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| A | 0015379 | molecular_function | potassium:chloride symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030424 | cellular_component | axon |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055064 | biological_process | chloride ion homeostasis |
| A | 0055075 | biological_process | potassium ion homeostasis |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071333 | biological_process | cellular response to glucose stimulus |
| A | 0071477 | biological_process | cellular hypotonic salinity response |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
| B | 0001525 | biological_process | angiogenesis |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0006884 | biological_process | cell volume homeostasis |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| B | 0015379 | molecular_function | potassium:chloride symporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0030424 | cellular_component | axon |
| B | 0045202 | cellular_component | synapse |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055064 | biological_process | chloride ion homeostasis |
| B | 0055075 | biological_process | potassium ion homeostasis |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0071333 | biological_process | cellular response to glucose stimulus |
| B | 0071477 | biological_process | cellular hypotonic salinity response |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 1902476 | biological_process | chloride transmembrane transport |
| B | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1374 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | MET1-GLY135 | |
| B | VAL495-SER517 | |
| B | SER562-ILE578 | |
| B | LEU615-SER1099 | |
| A | MET138-VAL160 | |
| A | GLY404-LYS413 | |
| A | VAL495-SER517 | |
| A | SER562-ILE578 | |
| A | LEU615-SER1099 | |
| B | MET1-GLY135 | |
| B | MET138-VAL160 | |
| B | GLY404-LYS413 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | TRANSMEM: Discontinuously helical; Name=1 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | PHE85-ASN107 | |
| B | PHE85-ASN107 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 338 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | LEU108-GLU114 | |
| A | VAL195-GLU212 | |
| A | ASN266-GLN382 | |
| A | LEU437-ILE467 | |
| B | LEU108-GLU114 | |
| B | VAL195-GLU212 | |
| B | ASN266-GLN382 | |
| B | LEU437-ILE467 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | HIS115-PHE137 | |
| B | HIS115-PHE137 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 66 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | VAL161-GLY194 | |
| B | VAL161-GLY194 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | PHE213-ALA236 | |
| B | PHE213-ALA236 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 56 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | ILE237-ASN265 | |
| B | ILE237-ASN265 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | GLY383-LYS403 | |
| B | GLY383-LYS403 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | SER414-LEU436 | |
| B | SER414-LEU436 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 52 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | GLY468-VAL494 | |
| B | GLY468-VAL494 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | PRO518-THR538 | |
| B | PRO518-THR538 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | GLY539-HIS561 | |
| B | GLY539-HIS561 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 38 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | ALA579-PHE598 | |
| B | ALA579-PHE598 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | PHE599-THR614 | |
| B | PHE599-THR614 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y, ECO:0007744|PDB:6M22 |
| Chain | Residue | Details |
| A | SER96 | |
| B | SER97 | |
| B | ILE392 | |
| B | THR393 | |
| B | ASN395 | |
| B | LEU396 | |
| B | TRP397 | |
| B | ILE552 | |
| A | SER97 | |
| A | ILE392 | |
| A | THR393 | |
| A | ASN395 | |
| A | LEU396 | |
| A | TRP397 | |
| A | ILE552 | |
| B | SER96 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:33199848, ECO:0007744|PDB:6M1Y |
| Chain | Residue | Details |
| A | ASN100 | |
| B | ASN100 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19665974, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | ARG32 | |
| B | ARG32 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER69 | |
| A | SER97 | |
| B | SER69 | |
| B | SER97 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | SER685 | |
| A | SER930 | |
| B | SER685 | |
| B | SER930 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | THR727 | |
| B | THR727 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:19665974, ECO:0000269|PubMed:27485015, ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | ASP940 | |
| B | ASP940 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19665974 |
| Chain | Residue | Details |
| A | SER972 | |
| A | SER978 | |
| B | SER972 | |
| B | SER978 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER981 | |
| B | SER981 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:19665974 |
| Chain | Residue | Details |
| A | ASP997 | |
| B | ASP997 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | TYR1070 | |
| B | TYR1070 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN328 | |
| A | ASN347 | |
| A | ASN360 | |
| A | ASN377 | |
| B | ASN328 | |
| B | ASN347 | |
| B | ASN360 | |
| B | ASN377 |
