6Y4S

Human kallikrein-related peptidase 7 (KLK7) in the unliganded state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001533	cellular_component	cornified envelope
A	0002780	biological_process	antibacterial peptide biosynthetic process
A	0004222	molecular_function	metalloendopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0008544	biological_process	epidermis development
A	0016787	molecular_function	hydrolase activity
A	0022617	biological_process	extracellular matrix disassembly
A	0030141	cellular_component	secretory granule
A	0051604	biological_process	protein maturation
A	0097209	cellular_component	epidermal lamellar body
B	0001533	cellular_component	cornified envelope
B	0002780	biological_process	antibacterial peptide biosynthetic process
B	0004222	molecular_function	metalloendopeptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005886	cellular_component	plasma membrane
B	0006508	biological_process	proteolysis
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0008544	biological_process	epidermis development
B	0016787	molecular_function	hydrolase activity
B	0022617	biological_process	extracellular matrix disassembly
B	0030141	cellular_component	secretory granule
B	0051604	biological_process	protein maturation
B	0097209	cellular_component	epidermal lamellar body
C	0001533	cellular_component	cornified envelope
C	0002780	biological_process	antibacterial peptide biosynthetic process
C	0004222	molecular_function	metalloendopeptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005886	cellular_component	plasma membrane
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0008544	biological_process	epidermis development
C	0016787	molecular_function	hydrolase activity
C	0022617	biological_process	extracellular matrix disassembly
C	0030141	cellular_component	secretory granule
C	0051604	biological_process	protein maturation
C	0097209	cellular_component	epidermal lamellar body

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue PGE A 301

Chain	Residue
A	TRP215
B	PHE218

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 302

Chain	Residue
A	LYS59
A	SER88
A	PHE89
A	ARG90
A	SO4305

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 303

Chain	Residue
A	GLU62
A	MET60
A	ASN61

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 304

Chain	Residue
A	PRO165
A	ASN178
A	LYS233
A	HOH409

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 305

Chain	Residue
A	LYS59
A	SER84
A	LYS87
A	SER88
A	SO4302

---

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 A 306

Chain	Residue
A	VAL158
A	ASP159
A	LYS188

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 A 307

Chain	Residue
A	SER125
A	ARG127
C	ARG80

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 B 301

Chain	Residue
B	ARG50
B	ASN109
B	SER110
B	GLN111

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 B 302

Chain	Residue
B	LYS59
B	SER84
B	LYS87
B	SER88
B	SO4303

---

site_id	AD1
Number of Residues	5
Details	binding site for residue SO4 B 303

Chain	Residue
B	LYS59
B	SER88
B	PHE89
B	ARG90
B	SO4302

---

site_id	AD2
Number of Residues	5
Details	binding site for residue SO4 C 301

Chain	Residue
C	LYS59
C	SER88
C	PHE89
C	ARG90
C	SO4304

---

site_id	AD3
Number of Residues	3
Details	binding site for residue SO4 C 302

Chain	Residue
C	ARG50
C	SER110
C	GLN111

---

site_id	AD4
Number of Residues	2
Details	binding site for residue SO4 C 303

Chain	Residue
C	ARG50
C	GLN111

---

site_id	AD5
Number of Residues	5
Details	binding site for residue SO4 C 304

Chain	Residue
C	LYS59
C	ASN61
C	LYS87
C	SER88
C	SO4301

---

site_id	AD6
Number of Residues	3
Details	binding site for residue SO4 C 305

Chain	Residue
C	MET60
C	ASN61
C	GLU62

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. NAcnGDSGGPLV

Chain	Residue	Details
A	ASN189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	660
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"17909180","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Site: {"description":"Major binding site for inhibitory zinc or copper"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---