6Y1J
14-3-3 sigma in complex with IkappaBalpha pS63 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0001836 | biological_process | release of cytochrome c from mitochondria |
| A | 0003334 | biological_process | keratinocyte development |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006469 | biological_process | negative regulation of protein kinase activity |
| A | 0006611 | biological_process | protein export from nucleus |
| A | 0007165 | biological_process | signal transduction |
| A | 0008104 | biological_process | protein localization |
| A | 0008426 | molecular_function | protein kinase C inhibitor activity |
| A | 0008630 | biological_process | intrinsic apoptotic signaling pathway in response to DNA damage |
| A | 0010482 | biological_process | regulation of epidermal cell division |
| A | 0010737 | biological_process | protein kinase A signaling |
| A | 0010839 | biological_process | negative regulation of keratinocyte proliferation |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030216 | biological_process | keratinocyte differentiation |
| A | 0030307 | biological_process | positive regulation of cell growth |
| A | 0031424 | biological_process | keratinization |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043588 | biological_process | skin development |
| A | 0043616 | biological_process | keratinocyte proliferation |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0045606 | biological_process | positive regulation of epidermal cell differentiation |
| A | 0045785 | biological_process | positive regulation of cell adhesion |
| A | 0045824 | biological_process | negative regulation of innate immune response |
| A | 0046827 | biological_process | positive regulation of protein export from nucleus |
| A | 0050815 | molecular_function | phosphoserine residue binding |
| A | 0051219 | molecular_function | phosphoprotein binding |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0061436 | biological_process | establishment of skin barrier |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0072089 | biological_process | stem cell proliferation |
| A | 0140311 | molecular_function | protein sequestering activity |
| A | 1903077 | biological_process | negative regulation of protein localization to plasma membrane |
| A | 1903829 | biological_process | positive regulation of protein localization |
| A | 2000647 | biological_process | negative regulation of stem cell proliferation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 301 |
| Chain | Residue |
| A | GLU35 |
| A | GLU110 |
| A | GLU188 |
| A | HOH552 |
| A | HOH602 |
| A | HOH638 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 302 |
| Chain | Residue |
| A | LYS9 |
| A | HOH660 |
| A | HOH688 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 303 |
| Chain | Residue |
| A | GLU75 |
| A | GLU161 |
| A | HOH485 |
| A | HOH572 |
| A | HOH622 |
| A | HOH635 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | LYS124 |
| A | TYR128 |
| A | SER146 |
| A | HOH454 |
| A | HOH461 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | GLY-4 |
| A | GLU76 |
| A | GLY78 |
| A | PRO79 |
| A | ARG82 |
| A | HOH484 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | TYR48 |
| A | VAL95 |
| A | THR98 |
| A | HOH532 |
| A | HOH651 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 307 |
| Chain | Residue |
| A | TYR19 |
| A | ASN50 |
| A | HOH440 |
| A | HOH563 |
| P | TRP66 |
| P | LYS67 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 308 |
| Chain | Residue |
| A | ASP97 |
| A | LEU100 |
| A | TYR128 |
| A | HOH402 |
| A | HOH416 |
| A | HOH535 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 309 |
| Chain | Residue |
| A | ARG148 |
| A | ASP211 |
| A | ASP215 |
| A | HOH430 |
| A | HOH566 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 310 |
| Chain | Residue |
| A | GLU110 |
| A | MET202 |
| A | LEU205 |
| A | TYR213 |
| A | HOH403 |
| A | HOH428 |
| A | HOH441 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 311 |
| Chain | Residue |
| A | TYR19 |
| A | GLU20 |
| A | HOH587 |
| A | HOH624 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Interaction with phosphoserine on interacting protein |
| Chain | Residue | Details |
| A | ARG56 | |
| A | ARG129 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER5 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER74 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER248 |
