Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Y0F

Structure of human FAPalpha in complex with linagliptin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0002020	molecular_function	protease binding
A	0004175	molecular_function	endopeptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005178	molecular_function	integrin binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006508	biological_process	proteolysis
A	0006915	biological_process	apoptotic process
A	0007155	biological_process	cell adhesion
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0008239	molecular_function	dipeptidyl-peptidase activity
A	0009986	cellular_component	cell surface
A	0010710	biological_process	regulation of collagen catabolic process
A	0010716	biological_process	negative regulation of extracellular matrix disassembly
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0030027	cellular_component	lamellipodium
A	0031258	cellular_component	lamellipodium membrane
A	0032587	cellular_component	ruffle membrane
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0042995	cellular_component	cell projection
A	0043542	biological_process	endothelial cell migration
A	0045177	cellular_component	apical part of cell
A	0045178	cellular_component	basal part of cell
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0051726	biological_process	regulation of cell cycle
A	0051917	biological_process	regulation of fibrinolysis
A	0060244	biological_process	negative regulation of cell proliferation involved in contact inhibition
A	0097325	biological_process	melanocyte proliferation
A	1900119	biological_process	positive regulation of execution phase of apoptosis
A	1902362	biological_process	melanocyte apoptotic process
A	1903054	biological_process	negative regulation of extracellular matrix organization
A	1905368	cellular_component	peptidase complex
B	0001525	biological_process	angiogenesis
B	0002020	molecular_function	protease binding
B	0004175	molecular_function	endopeptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005178	molecular_function	integrin binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006508	biological_process	proteolysis
B	0006915	biological_process	apoptotic process
B	0007155	biological_process	cell adhesion
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0008239	molecular_function	dipeptidyl-peptidase activity
B	0009986	cellular_component	cell surface
B	0010710	biological_process	regulation of collagen catabolic process
B	0010716	biological_process	negative regulation of extracellular matrix disassembly
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0030027	cellular_component	lamellipodium
B	0031258	cellular_component	lamellipodium membrane
B	0032587	cellular_component	ruffle membrane
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042995	cellular_component	cell projection
B	0043542	biological_process	endothelial cell migration
B	0045177	cellular_component	apical part of cell
B	0045178	cellular_component	basal part of cell
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0051726	biological_process	regulation of cell cycle
B	0051917	biological_process	regulation of fibrinolysis
B	0060244	biological_process	negative regulation of cell proliferation involved in contact inhibition
B	0097325	biological_process	melanocyte proliferation
B	1900119	biological_process	positive regulation of execution phase of apoptosis
B	1902362	biological_process	melanocyte apoptotic process
B	1903054	biological_process	negative regulation of extracellular matrix organization
B	1905368	cellular_component	peptidase complex
C	0001525	biological_process	angiogenesis
C	0002020	molecular_function	protease binding
C	0004175	molecular_function	endopeptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005178	molecular_function	integrin binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0006508	biological_process	proteolysis
C	0006915	biological_process	apoptotic process
C	0007155	biological_process	cell adhesion
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0008239	molecular_function	dipeptidyl-peptidase activity
C	0009986	cellular_component	cell surface
C	0010710	biological_process	regulation of collagen catabolic process
C	0010716	biological_process	negative regulation of extracellular matrix disassembly
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0030027	cellular_component	lamellipodium
C	0031258	cellular_component	lamellipodium membrane
C	0032587	cellular_component	ruffle membrane
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0042995	cellular_component	cell projection
C	0043542	biological_process	endothelial cell migration
C	0045177	cellular_component	apical part of cell
C	0045178	cellular_component	basal part of cell
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0051726	biological_process	regulation of cell cycle
C	0051917	biological_process	regulation of fibrinolysis
C	0060244	biological_process	negative regulation of cell proliferation involved in contact inhibition
C	0097325	biological_process	melanocyte proliferation
C	1900119	biological_process	positive regulation of execution phase of apoptosis
C	1902362	biological_process	melanocyte apoptotic process
C	1903054	biological_process	negative regulation of extracellular matrix organization
C	1905368	cellular_component	peptidase complex
D	0001525	biological_process	angiogenesis
D	0002020	molecular_function	protease binding
D	0004175	molecular_function	endopeptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005178	molecular_function	integrin binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006508	biological_process	proteolysis
D	0006915	biological_process	apoptotic process
D	0007155	biological_process	cell adhesion
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0008239	molecular_function	dipeptidyl-peptidase activity
D	0009986	cellular_component	cell surface
D	0010710	biological_process	regulation of collagen catabolic process
D	0010716	biological_process	negative regulation of extracellular matrix disassembly
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0030027	cellular_component	lamellipodium
D	0031258	cellular_component	lamellipodium membrane
D	0032587	cellular_component	ruffle membrane
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042995	cellular_component	cell projection
D	0043542	biological_process	endothelial cell migration
D	0045177	cellular_component	apical part of cell
D	0045178	cellular_component	basal part of cell
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0051726	biological_process	regulation of cell cycle
D	0051917	biological_process	regulation of fibrinolysis
D	0060244	biological_process	negative regulation of cell proliferation involved in contact inhibition
D	0097325	biological_process	melanocyte proliferation
D	1900119	biological_process	positive regulation of execution phase of apoptosis
D	1902362	biological_process	melanocyte apoptotic process
D	1903054	biological_process	negative regulation of extracellular matrix organization
D	1905368	cellular_component	peptidase complex

Functional Information from PROSITE/UniProt

site_id	PS00708
Number of Residues	31
Details	PRO_ENDOPEP_SER Prolyl endopeptidase family serine active site. DqitAvrkFiemgfidekriaiwGwSyGGYV

Chain	Residue	Details
A	ASP599-VAL629

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU10084","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15809306","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"15809306","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15809306","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15809306","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15809306","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)