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6Y0F

Structure of human FAPalpha in complex with linagliptin

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0002020molecular_functionprotease binding
A0004175molecular_functionendopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0007155biological_processcell adhesion
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0008239molecular_functiondipeptidyl-peptidase activity
A0009986cellular_componentcell surface
A0010710biological_processregulation of collagen catabolic process
A0010716biological_processnegative regulation of extracellular matrix disassembly
A0016020cellular_componentmembrane
A0030027cellular_componentlamellipodium
A0031258cellular_componentlamellipodium membrane
A0032587cellular_componentruffle membrane
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042995cellular_componentcell projection
A0043542biological_processendothelial cell migration
A0045177cellular_componentapical part of cell
A0045178cellular_componentbasal part of cell
A0051603biological_processproteolysis involved in protein catabolic process
A0051726biological_processregulation of cell cycle
A0051917biological_processregulation of fibrinolysis
A0060244biological_processnegative regulation of cell proliferation involved in contact inhibition
A0070161cellular_componentanchoring junction
A0097325biological_processmelanocyte proliferation
A1900119biological_processpositive regulation of execution phase of apoptosis
A1902362biological_processmelanocyte apoptotic process
A1903054biological_processnegative regulation of extracellular matrix organization
A1905368cellular_componentpeptidase complex
B0001525biological_processangiogenesis
B0002020molecular_functionprotease binding
B0004175molecular_functionendopeptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0007155biological_processcell adhesion
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0008239molecular_functiondipeptidyl-peptidase activity
B0009986cellular_componentcell surface
B0010710biological_processregulation of collagen catabolic process
B0010716biological_processnegative regulation of extracellular matrix disassembly
B0016020cellular_componentmembrane
B0030027cellular_componentlamellipodium
B0031258cellular_componentlamellipodium membrane
B0032587cellular_componentruffle membrane
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042995cellular_componentcell projection
B0043542biological_processendothelial cell migration
B0045177cellular_componentapical part of cell
B0045178cellular_componentbasal part of cell
B0051603biological_processproteolysis involved in protein catabolic process
B0051726biological_processregulation of cell cycle
B0051917biological_processregulation of fibrinolysis
B0060244biological_processnegative regulation of cell proliferation involved in contact inhibition
B0070161cellular_componentanchoring junction
B0097325biological_processmelanocyte proliferation
B1900119biological_processpositive regulation of execution phase of apoptosis
B1902362biological_processmelanocyte apoptotic process
B1903054biological_processnegative regulation of extracellular matrix organization
B1905368cellular_componentpeptidase complex
C0001525biological_processangiogenesis
C0002020molecular_functionprotease binding
C0004175molecular_functionendopeptidase activity
C0004252molecular_functionserine-type endopeptidase activity
C0005178molecular_functionintegrin binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0006508biological_processproteolysis
C0006915biological_processapoptotic process
C0007155biological_processcell adhesion
C0008233molecular_functionpeptidase activity
C0008236molecular_functionserine-type peptidase activity
C0008239molecular_functiondipeptidyl-peptidase activity
C0009986cellular_componentcell surface
C0010710biological_processregulation of collagen catabolic process
C0010716biological_processnegative regulation of extracellular matrix disassembly
C0016020cellular_componentmembrane
C0030027cellular_componentlamellipodium
C0031258cellular_componentlamellipodium membrane
C0032587cellular_componentruffle membrane
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0042995cellular_componentcell projection
C0043542biological_processendothelial cell migration
C0045177cellular_componentapical part of cell
C0045178cellular_componentbasal part of cell
C0051603biological_processproteolysis involved in protein catabolic process
C0051726biological_processregulation of cell cycle
C0051917biological_processregulation of fibrinolysis
C0060244biological_processnegative regulation of cell proliferation involved in contact inhibition
C0070161cellular_componentanchoring junction
C0097325biological_processmelanocyte proliferation
C1900119biological_processpositive regulation of execution phase of apoptosis
C1902362biological_processmelanocyte apoptotic process
C1903054biological_processnegative regulation of extracellular matrix organization
C1905368cellular_componentpeptidase complex
D0001525biological_processangiogenesis
D0002020molecular_functionprotease binding
D0004175molecular_functionendopeptidase activity
D0004252molecular_functionserine-type endopeptidase activity
D0005178molecular_functionintegrin binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0006508biological_processproteolysis
D0006915biological_processapoptotic process
D0007155biological_processcell adhesion
D0008233molecular_functionpeptidase activity
D0008236molecular_functionserine-type peptidase activity
D0008239molecular_functiondipeptidyl-peptidase activity
D0009986cellular_componentcell surface
D0010710biological_processregulation of collagen catabolic process
D0010716biological_processnegative regulation of extracellular matrix disassembly
D0016020cellular_componentmembrane
D0030027cellular_componentlamellipodium
D0031258cellular_componentlamellipodium membrane
D0032587cellular_componentruffle membrane
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0042995cellular_componentcell projection
D0043542biological_processendothelial cell migration
D0045177cellular_componentapical part of cell
D0045178cellular_componentbasal part of cell
D0051603biological_processproteolysis involved in protein catabolic process
D0051726biological_processregulation of cell cycle
D0051917biological_processregulation of fibrinolysis
D0060244biological_processnegative regulation of cell proliferation involved in contact inhibition
D0070161cellular_componentanchoring junction
D0097325biological_processmelanocyte proliferation
D1900119biological_processpositive regulation of execution phase of apoptosis
D1902362biological_processmelanocyte apoptotic process
D1903054biological_processnegative regulation of extracellular matrix organization
D1905368cellular_componentpeptidase complex
Functional Information from PROSITE/UniProt
site_idPS00708
Number of Residues31
DetailsPRO_ENDOPEP_SER Prolyl endopeptidase family serine active site. DqitAvrkFiemgfidekriaiwGwSyGGYV
ChainResidueDetails
AASP599-VAL629

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10084, ECO:0000269|PubMed:15809306
ChainResidueDetails
DSER624
BSER624
CSER624
ASER624

site_idSWS_FT_FI2
Number of Residues8
DetailsACT_SITE: Charge relay system => ECO:0000269|PubMed:15809306
ChainResidueDetails
BASP702
BHIS734
CASP702
CHIS734
DASP702
DHIS734
AASP702
AHIS734

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000303|PubMed:15809306
ChainResidueDetails
DGLU203
DGLU204
BGLU203
BGLU204
CGLU203
CGLU204
AGLU203
AGLU204

site_idSWS_FT_FI4
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:15809306
ChainResidueDetails
AASN49
AASN92
AASN314
BASN49
BASN92
BASN314
CASN49
CASN92
CASN314
DASN49
DASN92
DASN314

site_idSWS_FT_FI5
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:16335952
ChainResidueDetails
AASN99
BASN99
CASN99
DASN99

site_idSWS_FT_FI6
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:15809306, ECO:0000269|PubMed:16335952
ChainResidueDetails
AASN227
BASN227
CASN227
DASN227

site_idSWS_FT_FI7
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
AASN679
BASN679
CASN679
DASN679

219869

PDB entries from 2024-05-15

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