6XWH

Crystal Structure of the Human RXR DNA-Binding Domain Homodimer Bound to the Human Hoxb13 DR0 Response Element

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008270	molecular_function	zinc ion binding
C	0043565	molecular_function	sequence-specific DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0008270	molecular_function	zinc ion binding
D	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN C 301

Chain	Residue
C	CYS135
C	CYS138
C	CYS152
C	CYS155

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN C 302

Chain	Residue
C	CYS171
C	CYS177
C	CYS187
C	CYS190

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site_id	AC3
Number of Residues	4
Details	binding site for residue ZN D 301

Chain	Residue
D	CYS138
D	CYS152
D	CYS155
D	CYS135

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site_id	AC4
Number of Residues	4
Details	binding site for residue ZN D 302

Chain	Residue
D	CYS171
D	CYS177
D	CYS187
D	CYS190

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Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CaiCg.Drssgk.HYgvysCegCkgFFkR

Chain	Residue	Details
C	CYS135-ARG161

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700

Chain	Residue	Details
C	GLU153
C	LEU167
D	GLU153
D	LEU167

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700

Chain	Residue	Details
C	ILE179
D	ILE179

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:16912044

Chain	Residue	Details
C	VAL205
D	VAL205

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