6XW7

Crystal structure of murine norovirus P domain in complex with Nanobody NB-5829 and glycochenodeoxycholate (GCDCA)

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 601

Chain	Residue
A	TYR295
A	GLN340
A	THR341
A	GLU342
A	VAL387
A	VAL391

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 602

Chain	Residue
A	PRO422
A	HOH718
C	THR69
A	ASN261
A	PRO419
A	GLY421

---

site_id	AC3
Number of Residues	17
Details	binding site for residue CHO A 603

Chain	Residue
A	TRP245
A	ALA247
A	TYR435
A	MET436
A	ARG437
A	HOH715
A	HOH750
A	HOH824
A	HOH856
B	ALA290
B	ILE310
B	GLN312
B	GLY314
B	ARG390
B	VAL391
B	ARG392
B	HOH777

---

site_id	AC4
Number of Residues	16
Details	binding site for residue CHO B 601

Chain	Residue
A	ILE310
A	GLN312
A	GLY314
A	ARG390
A	VAL391
A	ARG392
A	HOH777
B	TRP245
B	ALA247
B	TYR250
B	TYR435
B	ARG437
B	HOH721
B	HOH751
B	HOH755
B	HOH787

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG B 602

Chain	Residue
B	GLN438
B	ASP440
B	GLU447
B	HOH710
B	HOH854
B	HOH863

---

site_id	AC6
Number of Residues	7
Details	binding site for residue EDO E 601

Chain	Residue
E	TYR295
E	GLN340
E	THR341
E	GLU342
E	VAL387
E	ARG390
E	VAL391

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO E 602

Chain	Residue
E	ASN261
E	PRO419
E	GLY421
E	PRO422

---

site_id	AC8
Number of Residues	14
Details	binding site for residue CHO E 603

Chain	Residue
E	TRP245
E	ALA247
E	TYR250
E	TYR435
E	ARG437
E	HOH738
E	HOH772
E	HOH784
F	ALA290
F	GLN312
F	GLY314
F	ARG390
F	VAL391
F	ARG392

---

site_id	AC9
Number of Residues	10
Details	binding site for residue CHO F 900

Chain	Residue
E	GLN312
E	ARG390
E	VAL391
E	ARG392
E	HOH730
F	TRP245
F	ALA247
F	TYR435
F	ARG437
F	HOH1049

---

site_id	AD1
Number of Residues	7
Details	binding site for residue EDO C 700

Chain	Residue
A	LEU275
A	LEU276
C	SER50
C	ILE51
C	SER57
C	ASN59
C	ARG99

---

site_id	AD2
Number of Residues	9
Details	binding site for residue EDO D 700

Chain	Residue
D	ASN59
D	ARG99
D	HOH806
B	THR274
B	LEU275
B	LEU276
D	SER50
D	ILE51
D	SER57

---

site_id	AD3
Number of Residues	9
Details	binding site for residue EDO G 700

Chain	Residue
E	THR274
E	LEU275
E	LEU276
G	SER50
G	ILE51
G	SER57
G	ASN59
G	ARG99
G	HOH803

---

site_id	AD4
Number of Residues	7
Details	binding site for residue EDO H 700

Chain	Residue
F	THR274
F	LEU275
F	LEU276
H	SER50
H	SER57
H	ASN59
H	ARG99

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	52
Details	Region: {"description":"P1 sub-domain 1","evidences":[{"source":"UniProtKB","id":"Q83884","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	276
Details	Region: {"description":"P2 sub-domain","evidences":[{"source":"PubMed","id":"22258242","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	136
Details	Region: {"description":"Interaction with host receptor CD300LF","evidences":[{"source":"PubMed","id":"30194229","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---