6XVY

Human myelin protein P2 mutant R88Q

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008289	molecular_function	lipid binding
B	0015485	molecular_function	cholesterol binding
B	0015908	biological_process	fatty acid transport
B	0043209	cellular_component	myelin sheath
B	0061024	biological_process	membrane organization
B	0070062	cellular_component	extracellular exosome
C	0005504	molecular_function	fatty acid binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008289	molecular_function	lipid binding
C	0015485	molecular_function	cholesterol binding
C	0015908	biological_process	fatty acid transport
C	0043209	cellular_component	myelin sheath
C	0061024	biological_process	membrane organization
C	0070062	cellular_component	extracellular exosome
D	0005504	molecular_function	fatty acid binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008289	molecular_function	lipid binding
D	0015485	molecular_function	cholesterol binding
D	0015908	biological_process	fatty acid transport
D	0043209	cellular_component	myelin sheath
D	0061024	biological_process	membrane organization
D	0070062	cellular_component	extracellular exosome
E	0005504	molecular_function	fatty acid binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0008289	molecular_function	lipid binding
E	0015485	molecular_function	cholesterol binding
E	0015908	biological_process	fatty acid transport
E	0043209	cellular_component	myelin sheath
E	0061024	biological_process	membrane organization
E	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue PLM B 201

Chain	Residue
B	GLY33
B	PRO38
B	ALA75
B	ASP76
B	ARG106
B	ARG126
B	TYR128
B	HOH324
B	HOH353

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CL B 202

Chain	Residue
B	LYS37
B	THR56

---

site_id	AC3
Number of Residues	7
Details	binding site for residue PLM C 201

Chain	Residue
C	PHE16
C	ASP76
C	ARG106
C	ARG126
C	TYR128
C	HOH332
C	HOH369

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CL C 202

Chain	Residue
C	LYS37
C	SER55
C	THR56
C	HOH463

---

site_id	AC5
Number of Residues	13
Details	binding site for residue CIT C 203

Chain	Residue
C	GLY26
C	LEU27
C	ALA28
C	THR29
C	HOH317
C	HOH358
C	HOH367
C	HOH376
E	ALA28
E	THR29
E	LYS100
E	HOH355
E	HOH381

---

site_id	AC6
Number of Residues	8
Details	binding site for residue PLM D 201

Chain	Residue
D	MET20
D	THR29
D	GLY33
D	ARG106
D	ARG126
D	TYR128
D	HOH317
D	HOH341

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CL D 202

Chain	Residue
D	LYS37
D	SER55
D	THR56

---

site_id	AC8
Number of Residues	4
Details	binding site for residue CIT D 203

Chain	Residue
D	GLU69
D	HOH347
E	GLN88
E	HOH402

---

site_id	AC9
Number of Residues	6
Details	binding site for residue PLM E 201

Chain	Residue
E	ASP76
E	ARG106
E	CYS117
E	ARG126
E	TYR128
E	HOH308

---

site_id	AD1
Number of Residues	4
Details	binding site for residue CL E 202

Chain	Residue
E	LYS37
E	SER55
E	THR56
E	HOH318

---

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GTWkLvsSeNFDdYMKAL

Chain	Residue	Details
B	GLY6-LEU23

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:20421974, ECO:0007744|PDB:2WUT

Chain	Residue	Details
B	ARG106
B	ARG126
C	ARG106
C	ARG126
D	ARG106
D	ARG126
E	ARG106
E	ARG126

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylserine => ECO:0000269|PubMed:6183401

Chain	Residue	Details
B	SER1
C	SER1
D	SER1
E	SER1

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