6XU2
Human karyopherin RanBP5 (isoform-3)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002753 | biological_process | cytoplasmic pattern recognition receptor signaling pathway |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005095 | molecular_function | GTPase inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005643 | cellular_component | nuclear pore |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006606 | biological_process | protein import into nucleus |
| A | 0006607 | biological_process | NLS-bearing protein import into nucleus |
| A | 0006610 | biological_process | ribosomal protein import into nucleus |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0008139 | molecular_function | nuclear localization sequence binding |
| A | 0015031 | biological_process | protein transport |
| A | 0016020 | cellular_component | membrane |
| A | 0031267 | molecular_function | small GTPase binding |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0042307 | biological_process | positive regulation of protein import into nucleus |
| A | 0045786 | biological_process | negative regulation of cell cycle |
| A | 0061608 | molecular_function | nuclear import signal receptor activity |
| A | 0071230 | biological_process | cellular response to amino acid stimulus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue NI A 1201 |
| Chain | Residue |
| A | HIS765 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"HEAT 1","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 71 |
| Details | Domain: {"description":"Importin N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00115","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"HEAT 2","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 27 |
| Details | Repeat: {"description":"HEAT 3","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 27 |
| Details | Repeat: {"description":"HEAT 4","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"HEAT 5","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 6","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"HEAT 7","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 34 |
| Details | Repeat: {"description":"HEAT 9","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"HEAT 10","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"HEAT 11","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"HEAT 12","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"HEAT 13","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"HEAT 14","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 75 |
| Details | Repeat: {"description":"HEAT 15","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"HEAT 16","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"HEAT 17","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"HEAT 18","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"HEAT 19","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 32 |
| Details | Repeat: {"description":"HEAT 20","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"HEAT 21","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 31 |
| Details | Repeat: {"description":"HEAT 22","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"HEAT 23","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 23 |
| Details | Repeat: {"description":"HEAT 24","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
