6XU0

Archaeoglobus fulgidus Argonaute protein with DNA oligoduplex 5'-pATCGTGGCCACGAT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0046872	molecular_function	metal ion binding
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG A 501

Chain	Residue
A	GLN159
A	LEU427
R	DA1
R	DC3
R	HOH103

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CAC A 502

Chain	Residue
A	TYR360
A	TYR361

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CAC A 503

Chain	Residue
A	TYR410
B	LYS45
A	GLY408
A	GLY409

---

site_id	AC4
Number of Residues	5
Details	binding site for residue BME A 504

Chain	Residue
A	ILE213
A	SER214
A	ILE412
A	HOH710
A	HOH729

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL A 505

Chain	Residue
A	LYS227
A	SER228
A	LYS231
A	LYS232
A	HOH653
A	HOH667
A	HOH769

---

site_id	AC6
Number of Residues	2
Details	binding site for residue PG0 B 501

Chain	Residue
A	PHE298
B	TYR311

---

site_id	AC7
Number of Residues	5
Details	binding site for residue MG B 502

Chain	Residue
B	GLN159
B	LEU427
P	DA1
P	DC3
P	HOH105

---

site_id	AC8
Number of Residues	6
Details	binding site for residue CAC B 503

Chain	Residue
A	LYS45
B	LYS125
B	GLY408
B	GLY409
B	TYR410
B	HOH622

---

site_id	AC9
Number of Residues	6
Details	binding site for residue BME B 504

Chain	Residue
B	SER214
B	ILE401
B	PRO411
B	ILE412
B	ASN413
B	HOH641

---

site_id	AD1
Number of Residues	4
Details	binding site for residue K B 505

Chain	Residue
B	SER136
B	LYS163
B	TRP425
B	HOH731

---

site_id	AD2
Number of Residues	9
Details	binding site for residue GOL B 506

Chain	Residue
A	LYS97
A	ASP101
B	PRO42
B	SER43
B	LEU44
B	HIS77
B	ILE78
B	HIS79
B	HOH603

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	258
Details	Region: {"description":"Mid domain","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33633170","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Region: {"description":"Binds 5'-phosphorylated end of guide DNA","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Region: {"description":"Binds target DNA","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Region: {"description":"Binds guide DNA","evidences":[{"source":"PubMed","id":"19187762","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"1YTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BGG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2W42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---