Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6XTE

Human karyopherin RanBP5 (isoform-1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002753	biological_process	cytoplasmic pattern recognition receptor signaling pathway
A	0003723	molecular_function	RNA binding
A	0005095	molecular_function	GTPase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005643	cellular_component	nuclear pore
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006606	biological_process	protein import into nucleus
A	0006607	biological_process	NLS-bearing protein import into nucleus
A	0006610	biological_process	ribosomal protein import into nucleus
A	0006886	biological_process	intracellular protein transport
A	0008139	molecular_function	nuclear localization sequence binding
A	0015031	biological_process	protein transport
A	0016020	cellular_component	membrane
A	0031267	molecular_function	small GTPase binding
A	0031965	cellular_component	nuclear membrane
A	0042307	biological_process	positive regulation of protein import into nucleus
A	0045786	biological_process	negative regulation of cell cycle
A	0061608	molecular_function	nuclear import signal receptor activity
A	0071230	biological_process	cellular response to amino acid stimulus

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue NI A 1201

Chain	Residue
A	CYS802
A	ASN804
A	HIS807

site_id	AC2
Number of Residues	3
Details	binding site for residue NI A 1202

Chain	Residue
A	ARG68
A	GLN974
A	TRP1017

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 1203

Chain	Residue
A	HIS394
A	ARG432

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	33
Details	Repeat: {"description":"HEAT 1","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	71
Details	Domain: {"description":"Importin N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00115","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	34
Details	Repeat: {"description":"HEAT 2","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	27
Details	Repeat: {"description":"HEAT 3","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	27
Details	Repeat: {"description":"HEAT 4","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	34
Details	Repeat: {"description":"HEAT 5","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	36
Details	Repeat: {"description":"HEAT 6","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	35
Details	Repeat: {"description":"HEAT 7","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	34
Details	Repeat: {"description":"HEAT 9","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	40
Details	Repeat: {"description":"HEAT 10","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	40
Details	Repeat: {"description":"HEAT 11","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	48
Details	Repeat: {"description":"HEAT 12","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	43
Details	Repeat: {"description":"HEAT 13","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	75
Details	Repeat: {"description":"HEAT 15","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	42
Details	Repeat: {"description":"HEAT 16","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	39
Details	Repeat: {"description":"HEAT 17","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	66
Details	Repeat: {"description":"HEAT 18","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	32
Details	Repeat: {"description":"HEAT 20","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	40
Details	Repeat: {"description":"HEAT 21","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	31
Details	Repeat: {"description":"HEAT 22","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	35
Details	Repeat: {"description":"HEAT 23","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	23
Details	Repeat: {"description":"HEAT 24","evidences":[{"source":"UniProtKB","id":"P32337","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"23541588","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2006","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Kanor S.","Tissot J.-D.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)