Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6XR5

Crystal Structure of Diphosphomevalonate decarboxylase (MVD1) Cryptococcus neoformans var. grubii serotype A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004163	molecular_function	diphosphomevalonate decarboxylase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016126	biological_process	sterol biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
B	0004163	molecular_function	diphosphomevalonate decarboxylase activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016126	biological_process	sterol biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
C	0004163	molecular_function	diphosphomevalonate decarboxylase activity
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0008299	biological_process	isoprenoid biosynthetic process
C	0016126	biological_process	sterol biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
D	0004163	molecular_function	diphosphomevalonate decarboxylase activity
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0008299	biological_process	isoprenoid biosynthetic process
D	0016126	biological_process	sterol biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016831	molecular_function	carboxy-lyase activity
D	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
E	0004163	molecular_function	diphosphomevalonate decarboxylase activity
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0008299	biological_process	isoprenoid biosynthetic process
E	0016126	biological_process	sterol biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016831	molecular_function	carboxy-lyase activity
E	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
F	0004163	molecular_function	diphosphomevalonate decarboxylase activity
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0008299	biological_process	isoprenoid biosynthetic process
F	0016126	biological_process	sterol biosynthetic process
F	0016829	molecular_function	lyase activity
F	0016831	molecular_function	carboxy-lyase activity
F	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
G	0004163	molecular_function	diphosphomevalonate decarboxylase activity
G	0005524	molecular_function	ATP binding
G	0005829	cellular_component	cytosol
G	0008299	biological_process	isoprenoid biosynthetic process
G	0016126	biological_process	sterol biosynthetic process
G	0016829	molecular_function	lyase activity
G	0016831	molecular_function	carboxy-lyase activity
G	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
H	0004163	molecular_function	diphosphomevalonate decarboxylase activity
H	0005524	molecular_function	ATP binding
H	0005829	cellular_component	cytosol
H	0008299	biological_process	isoprenoid biosynthetic process
H	0016126	biological_process	sterol biosynthetic process
H	0016829	molecular_function	lyase activity
H	0016831	molecular_function	carboxy-lyase activity
H	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue SO4 A 401

Chain	Residue
A	TYR18
A	LYS21
A	ILE27
A	ARG75
A	SER154
A	GLY155
A	THR210
A	MET213
A	HOH514

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 402

Chain	Residue
A	ARG370
A	HOH636
A	HOH717
A	HOH805
D	PHE318
D	ARG342

site_id	AC3
Number of Residues	8
Details	binding site for residue ADE A 403

Chain	Residue
A	LEU63
A	LEU76
A	SER109
A	SER121
A	GLY125
A	LEU126
A	HOH505
A	HOH556

site_id	AC4
Number of Residues	9
Details	binding site for residue SO4 B 401

Chain	Residue
B	TYR18
B	LYS21
B	ILE27
B	ARG75
B	SER154
B	GLY155
B	THR210
B	HOH522
B	HOH541

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 B 402

Chain	Residue
B	ALA120
B	SER121
B	SER122

site_id	AC6
Number of Residues	7
Details	binding site for residue ADE B 403

Chain	Residue
B	LEU63
B	SER109
B	ASN111
B	SER121
B	GLY125
B	HOH524
B	HOH690

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 C 401

Chain	Residue
C	TYR18
C	LYS21
C	ILE27
C	GLY155
C	THR210
C	HOH503

site_id	AC8
Number of Residues	9
Details	binding site for residue SO4 D 401

Chain	Residue
D	TYR18
D	LYS21
D	ILE27
D	ARG75
D	SER154
D	GLY155
D	THR210
D	HOH520
D	HOH739

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 D 402

Chain	Residue
D	ALA120
D	SER121
D	SER122
D	HOH822

site_id	AD1
Number of Residues	6
Details	binding site for residue ADE D 403

Chain	Residue
D	LEU63
D	SER109
D	ASN111
D	SER121
D	GLY125
D	HOH530

site_id	AD2
Number of Residues	8
Details	binding site for residue SO4 E 401

Chain	Residue
E	TYR18
E	LYS21
E	ARG75
E	SER154
E	GLY155
E	THR210
E	HOH503
E	HOH763

site_id	AD3
Number of Residues	8
Details	binding site for residue ADE E 402

Chain	Residue
E	LEU63
E	SER109
E	ASN111
E	SER121
E	SER122
E	GLY125
E	HOH510
E	HOH543

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 E 403

Chain	Residue
E	ALA120
E	SER121
E	SER122
E	HOH546

site_id	AD5
Number of Residues	3
Details	binding site for residue SO4 F 401

Chain	Residue
F	ALA120
F	SER121
F	SER122

site_id	AD6
Number of Residues	6
Details	binding site for residue EDO F 402

Chain	Residue
F	ASN12
F	ILE13
F	ALA14
F	ARG159
F	ASP302
F	HOH568

site_id	AD7
Number of Residues	6
Details	binding site for residue EDO G 600

Chain	Residue
G	ARG159
G	ASP302
G	HOH709
G	ASN12
G	ILE13
G	ALA14

site_id	AD8
Number of Residues	9
Details	binding site for residue SO4 H 401

Chain	Residue
H	TYR18
H	LYS21
H	ILE27
H	ARG75
H	SER154
H	GLY155
H	THR210
H	MET213
H	HOH501

site_id	AD9
Number of Residues	6
Details	binding site for residue SO4 H 402

Chain	Residue
B	PHE318
B	ARG342
B	HOH613
H	ARG370
H	HOH734
H	HOH817

site_id	AE1
Number of Residues	8
Details	binding site for residue ADE H 403

Chain	Residue
H	LEU63
H	SER109
H	ASN111
H	SER121
H	GLY125
H	LEU126
H	HOH516
H	HOH526

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)