6XR5
Crystal Structure of Diphosphomevalonate decarboxylase (MVD1) Cryptococcus neoformans var. grubii serotype A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| B | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| C | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0016831 | molecular_function | carboxy-lyase activity |
| C | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| D | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0008299 | biological_process | isoprenoid biosynthetic process |
| D | 0016831 | molecular_function | carboxy-lyase activity |
| D | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| E | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005829 | cellular_component | cytosol |
| E | 0008299 | biological_process | isoprenoid biosynthetic process |
| E | 0016831 | molecular_function | carboxy-lyase activity |
| E | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| F | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005829 | cellular_component | cytosol |
| F | 0008299 | biological_process | isoprenoid biosynthetic process |
| F | 0016831 | molecular_function | carboxy-lyase activity |
| F | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| G | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005829 | cellular_component | cytosol |
| G | 0008299 | biological_process | isoprenoid biosynthetic process |
| G | 0016831 | molecular_function | carboxy-lyase activity |
| G | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| H | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005829 | cellular_component | cytosol |
| H | 0008299 | biological_process | isoprenoid biosynthetic process |
| H | 0016831 | molecular_function | carboxy-lyase activity |
| H | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | TYR18 |
| A | LYS21 |
| A | ILE27 |
| A | ARG75 |
| A | SER154 |
| A | GLY155 |
| A | THR210 |
| A | MET213 |
| A | HOH514 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ARG370 |
| A | HOH636 |
| A | HOH717 |
| A | HOH805 |
| D | PHE318 |
| D | ARG342 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue ADE A 403 |
| Chain | Residue |
| A | LEU63 |
| A | LEU76 |
| A | SER109 |
| A | SER121 |
| A | GLY125 |
| A | LEU126 |
| A | HOH505 |
| A | HOH556 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | TYR18 |
| B | LYS21 |
| B | ILE27 |
| B | ARG75 |
| B | SER154 |
| B | GLY155 |
| B | THR210 |
| B | HOH522 |
| B | HOH541 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | ALA120 |
| B | SER121 |
| B | SER122 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue ADE B 403 |
| Chain | Residue |
| B | LEU63 |
| B | SER109 |
| B | ASN111 |
| B | SER121 |
| B | GLY125 |
| B | HOH524 |
| B | HOH690 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 C 401 |
| Chain | Residue |
| C | TYR18 |
| C | LYS21 |
| C | ILE27 |
| C | GLY155 |
| C | THR210 |
| C | HOH503 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 D 401 |
| Chain | Residue |
| D | TYR18 |
| D | LYS21 |
| D | ILE27 |
| D | ARG75 |
| D | SER154 |
| D | GLY155 |
| D | THR210 |
| D | HOH520 |
| D | HOH739 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 402 |
| Chain | Residue |
| D | ALA120 |
| D | SER121 |
| D | SER122 |
| D | HOH822 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue ADE D 403 |
| Chain | Residue |
| D | LEU63 |
| D | SER109 |
| D | ASN111 |
| D | SER121 |
| D | GLY125 |
| D | HOH530 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 E 401 |
| Chain | Residue |
| E | TYR18 |
| E | LYS21 |
| E | ARG75 |
| E | SER154 |
| E | GLY155 |
| E | THR210 |
| E | HOH503 |
| E | HOH763 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue ADE E 402 |
| Chain | Residue |
| E | LEU63 |
| E | SER109 |
| E | ASN111 |
| E | SER121 |
| E | SER122 |
| E | GLY125 |
| E | HOH510 |
| E | HOH543 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 E 403 |
| Chain | Residue |
| E | ALA120 |
| E | SER121 |
| E | SER122 |
| E | HOH546 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 F 401 |
| Chain | Residue |
| F | ALA120 |
| F | SER121 |
| F | SER122 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO F 402 |
| Chain | Residue |
| F | ASN12 |
| F | ILE13 |
| F | ALA14 |
| F | ARG159 |
| F | ASP302 |
| F | HOH568 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO G 600 |
| Chain | Residue |
| G | ARG159 |
| G | ASP302 |
| G | HOH709 |
| G | ASN12 |
| G | ILE13 |
| G | ALA14 |
| site_id | AD8 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 H 401 |
| Chain | Residue |
| H | TYR18 |
| H | LYS21 |
| H | ILE27 |
| H | ARG75 |
| H | SER154 |
| H | GLY155 |
| H | THR210 |
| H | MET213 |
| H | HOH501 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 H 402 |
| Chain | Residue |
| B | PHE318 |
| B | ARG342 |
| B | HOH613 |
| H | ARG370 |
| H | HOH734 |
| H | HOH817 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue ADE H 403 |
| Chain | Residue |
| H | LEU63 |
| H | SER109 |
| H | ASN111 |
| H | SER121 |
| H | GLY125 |
| H | LEU126 |
| H | HOH516 |
| H | HOH526 |
