6XPF

Cryo-EM structure of human ZnT8 WT, in the absence of zinc, determined in heterogeneous conformations- one subunit in an inward-facing and the other in an outward-facing conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006812	biological_process	monoatomic cation transport
A	0008324	molecular_function	monoatomic cation transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0006812	biological_process	monoatomic cation transport
B	0008324	molecular_function	monoatomic cation transmembrane transporter activity
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue ZN A 401

Chain	Residue
A	ASP360
A	CYS361

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site_id	AC2
Number of Residues	1
Details	binding site for residue ZN A 402

Chain	Residue
A	CYS53

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site_id	AC3
Number of Residues	1
Details	binding site for residue ZN B 402

Chain	Residue
B	CYS361

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	226
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:16984975

Chain	Residue	Details
A	MET50-PRO128
A	GLN174-ASN189
A	ILE246-ILE266
B	MET50-PRO128
B	GLN174-ASN189
B	ILE246-ILE266

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site_id	SWS_FT_FI2
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	SER129-LEU149
B	LEU225-LYS245
B	LEU267-VAL287
B	ASP295-LEU315
A	VAL153-ILE173
A	ILE190-ALA210
A	LEU225-LYS245
A	LEU267-VAL287
A	ASP295-LEU315
B	SER129-LEU149
B	VAL153-ILE173
B	ILE190-ALA210

---

site_id	SWS_FT_FI3
Number of Residues	42
Details	TOPO_DOM: Lumenal, vesicle => ECO:0000269|PubMed:16984975

Chain	Residue	Details
A	CYS150-TRP152
A	ASN211-ASP224
A	LYS288-VAL294
B	CYS150-TRP152
B	ASN211-ASP224
B	LYS288-VAL294

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: in chain A => ECO:0000269|PubMed:32723473, ECO:0000312|PDB:6XPE

Chain	Residue	Details
A	VAL101
A	THR102
A	ASP103
B	VAL101
B	THR102
B	ASP103

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site_id	SWS_FT_FI5
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:32723473, ECO:0000312|PDB:6XPE

Chain	Residue	Details
A	THR155
B	LEU273
A	VAL159
A	VAL186
A	ASP269
A	LEU273
B	THR155
B	VAL159
B	VAL186
B	ASP269

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: in chain B => ECO:0000269|PubMed:32723473, ECO:0000312|PDB:6XPE

Chain	Residue	Details
A	GLN350
A	PRO367
B	GLN350
B	PRO367

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