6XNP
Crystal Structure of Human STING CTD complex with SR-717
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002218 | biological_process | activation of innate immune response |
| A | 0032481 | biological_process | positive regulation of type I interferon production |
| B | 0002218 | biological_process | activation of innate immune response |
| B | 0032481 | biological_process | positive regulation of type I interferon production |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue V67 A 401 |
| Chain | Residue |
| A | SER162 |
| A | HOH610 |
| B | ARG238 |
| B | THR263 |
| B | V67401 |
| A | TYR163 |
| A | TYR167 |
| A | ARG232 |
| A | ARG238 |
| A | TYR240 |
| A | GLU260 |
| A | THR263 |
| A | HOH553 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | ASP223 |
| A | LYS224 |
| A | LEU225 |
| A | PRO226 |
| A | HOH521 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue V67 B 401 |
| Chain | Residue |
| A | ILE235 |
| A | ARG238 |
| A | THR263 |
| A | PRO264 |
| A | V67401 |
| B | SER162 |
| B | TYR163 |
| B | GLY166 |
| B | TYR167 |
| B | ARG238 |
| B | TYR240 |
| B | SER241 |
| B | GLU260 |
| B | THR263 |
| B | HOH504 |
| B | HOH562 |
| B | HOH595 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 402 |
| Chain | Residue |
| B | ARG197 |
| B | ASN307 |
| B | SER321 |
| B | GLU336 |
| B | HOH513 |
| B | HOH519 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| B | ASP205 |
| B | LEU299 |
| B | ALA300 |
| B | SER305 |
| B | GLN306 |
| B | GLU316 |
| B | ASP320 |
| B | HOH507 |
| B | HOH525 |
| B | HOH606 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4F5Y |
| Chain | Residue | Details |
| A | SER162 | |
| B | SER162 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728659, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5D, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G |
| Chain | Residue | Details |
| A | TYR167 | |
| B | TYR167 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:37379839, ECO:0007744|PDB:8GJX |
| Chain | Residue | Details |
| A | ARG238 | |
| B | ARG238 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G |
| Chain | Residue | Details |
| A | THR263 | |
| B | THR263 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:37832545 |
| Chain | Residue | Details |
| A | THR229 | |
| B | THR229 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:37832545 |
| Chain | Residue | Details |
| A | SER241 | |
| B | SER241 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:31968013 |
| Chain | Residue | Details |
| A | LYS236 | |
| B | LYS236 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q3TBT3 |
| Chain | Residue | Details |
| A | LYS338 | |
| B | LYS338 |
