6XNK

Crystal structure of dimeric K72A human cytochrome c alkaline conformer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
A	0009055	molecular_function	electron transfer activity
A	0020037	molecular_function	heme binding
A	0045333	biological_process	cellular respiration
A	0097190	biological_process	apoptotic signaling pathway
A	0097193	biological_process	intrinsic apoptotic signaling pathway
A	0097194	biological_process	execution phase of apoptosis
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005829	cellular_component	cytosol
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
C	0009055	molecular_function	electron transfer activity
C	0020037	molecular_function	heme binding
C	0045333	biological_process	cellular respiration
C	0097190	biological_process	apoptotic signaling pathway
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0097194	biological_process	execution phase of apoptosis
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005829	cellular_component	cytosol
E	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
E	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
E	0009055	molecular_function	electron transfer activity
E	0020037	molecular_function	heme binding
E	0045333	biological_process	cellular respiration
E	0097190	biological_process	apoptotic signaling pathway
E	0097193	biological_process	intrinsic apoptotic signaling pathway
E	0097194	biological_process	execution phase of apoptosis
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005758	cellular_component	mitochondrial intermembrane space
G	0005829	cellular_component	cytosol
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
G	0009055	molecular_function	electron transfer activity
G	0020037	molecular_function	heme binding
G	0045333	biological_process	cellular respiration
G	0097190	biological_process	apoptotic signaling pathway
G	0097193	biological_process	intrinsic apoptotic signaling pathway
G	0097194	biological_process	execution phase of apoptosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue HEC A 201

Chain	Residue
A	LYS13
A	TYR48
A	THR49
A	ALA51
A	ASN52
A	TRP59
A	PRO76
A	LYS79
A	PHE82
A	HOH307
A	HOH313
A	CYS14
C	LEU94
A	CYS17
A	HIS18
A	THR28
A	PRO30
A	THR40
A	GLY41
A	TYR46

---

site_id	AC2
Number of Residues	22
Details	binding site for Di-peptide HEC C 201 and CYS C 14

Chain	Residue
C	PHE10
C	LYS13
C	SER15
C	GLN16
C	CYS17
C	HIS18
C	THR28
C	PRO30
C	GLY41
C	TYR46
C	TYR48
C	THR49
C	ASN52
C	TRP59
C	TYR67
C	LYS79
C	PHE82
C	VAL83
C	LYS86
C	HOH301
C	HOH306
C	HOH321

---

site_id	AC3
Number of Residues	22
Details	binding site for Di-peptide HEC E 201 and CYS E 17

Chain	Residue
E	LYS13
E	CYS14
E	SER15
E	GLN16
E	HIS18
E	LYS27
E	THR28
E	GLY29
E	PRO30
E	LEU35
E	GLY41
E	TYR48
E	THR49
E	ALA51
E	ASN52
E	TRP59
E	TYR67
E	LYS79
E	PHE82
E	LYS86
E	HOH304
E	HOH306

---

site_id	AC4
Number of Residues	22
Details	binding site for Di-peptide HEC E 201 and CYS E 14

Chain	Residue
E	PHE10
E	LYS13
E	SER15
E	GLN16
E	CYS17
E	HIS18
E	THR28
E	GLY29
E	PRO30
E	LEU35
E	GLY41
E	TYR48
E	THR49
E	ALA51
E	ASN52
E	TRP59
E	TYR67
E	LYS79
E	PHE82
E	LYS86
E	HOH304
E	HOH306

---

site_id	AC5
Number of Residues	22
Details	binding site for Di-peptide HEC G 201 and CYS G 14

Chain	Residue
G	ALA51
G	ASN52
G	TRP59
G	TYR67
G	PRO76
G	LYS79
G	PHE82
G	LYS86
G	HOH313
G	PHE10
G	MET12
G	LYS13
G	SER15
G	GLN16
G	CYS17
G	HIS18
G	THR28
G	THR40
G	GLY41
G	TYR46
G	TYR48
G	THR49

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"description":"covalent","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23150584","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23150584","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N-acetylglycine","evidences":[{"source":"PubMed","id":"13933734","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62894","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---