6XD0

Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-434

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005524	molecular_function	ATP binding
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1001

Chain	Residue
A	HIS712
A	HIS714
A	CYS728
A	CYS847

---

site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 1002

Chain	Residue
A	ASP826
A	ARG722
A	LYS723
A	TRP823
A	MET824
A	GLU825

---

site_id	AC3
Number of Residues	5
Details	binding site for residue PEG A 1003

Chain	Residue
A	ASP435
A	ASN635
A	HIS637
A	GOL1004
A	HOH1101

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 1004

Chain	Residue
A	GLU428
A	LYS432
A	ASP435
A	PEG1003
A	HOH1145
A	HOH1218

---

site_id	AC5
Number of Residues	1
Details	binding site for residue PEG A 1005

Chain	Residue
A	LYS656

---

site_id	AC6
Number of Residues	11
Details	binding site for residue GOL A 1006

Chain	Residue
A	PRO363
A	ASN682
A	ASP683
A	GLN693
A	LYS827
A	THR828
A	PRO829
A	HOH1144
A	HOH1146
A	HOH1236
A	HOH1342

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN A 1007

Chain	Residue
A	GLU437
A	HIS441
A	CYS446
A	CYS449

---

site_id	AC8
Number of Residues	9
Details	binding site for residue V0M A 1008

Chain	Residue
A	PHE398
A	LYS401
A	TRP418
A	ARG481
A	PHE485
A	ASN492
A	VAL603
A	TRP795
A	ILE797

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17301146","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	150
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---