Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6XB3

Structure of AcNPV poxin in post-reactive state with Gp[2'-5']Ap[3']

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004518	molecular_function	nuclease activity
A	0016787	molecular_function	hydrolase activity
A	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
B	0004518	molecular_function	nuclease activity
B	0016787	molecular_function	hydrolase activity
B	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
C	0004518	molecular_function	nuclease activity
C	0016787	molecular_function	hydrolase activity
C	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
D	0004518	molecular_function	nuclease activity
D	0016787	molecular_function	hydrolase activity
D	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
E	0004518	molecular_function	nuclease activity
E	0016787	molecular_function	hydrolase activity
E	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
F	0004518	molecular_function	nuclease activity
F	0016787	molecular_function	hydrolase activity
F	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
G	0004518	molecular_function	nuclease activity
G	0016787	molecular_function	hydrolase activity
G	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
H	0004518	molecular_function	nuclease activity
H	0016787	molecular_function	hydrolase activity
H	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
I	0004518	molecular_function	nuclease activity
I	0016787	molecular_function	hydrolase activity
I	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
J	0004518	molecular_function	nuclease activity
J	0016787	molecular_function	hydrolase activity
J	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
K	0004518	molecular_function	nuclease activity
K	0016787	molecular_function	hydrolase activity
K	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
L	0004518	molecular_function	nuclease activity
L	0016787	molecular_function	hydrolase activity
L	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
M	0004518	molecular_function	nuclease activity
M	0016787	molecular_function	hydrolase activity
M	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
N	0004518	molecular_function	nuclease activity
N	0016787	molecular_function	hydrolase activity
N	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
O	0004518	molecular_function	nuclease activity
O	0016787	molecular_function	hydrolase activity
O	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
P	0004518	molecular_function	nuclease activity
P	0016787	molecular_function	hydrolase activity
P	0061507	molecular_function	2',3'-cyclic GMP-AMP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue 9BG A 301

Chain	Residue
A	SER172
A	ARG226
A	HOH437
A	HOH450
A	HOH464
A	HOH488
A	HOH493
A	HOH515
B	SER43
B	TYR45
B	HIS46
A	VAL173
B	GLN47
B	PHE48
B	ARG93
B	ILE146
B	ARG147
B	SER153
B	HIS155
B	HOH447
B	HOH491
A	TYR181
A	ILE184
A	LYS185
A	ALA188
A	LEU189
A	ARG212
A	HIS224

site_id	AC2
Number of Residues	27
Details	binding site for residue 9BG B 301

Chain	Residue
A	SER43
A	HIS46
A	GLN47
A	PHE48
A	ARG93
A	ILE146
A	ARG147
A	SER153
A	HOH483
B	SER172
B	VAL173
B	TYR181
B	ILE184
B	LYS185
B	ALA188
B	LEU189
B	ARG212
B	HIS224
B	ARG226
B	HOH415
B	HOH464
B	HOH465
B	HOH474
B	HOH495
B	HOH502
B	HOH532
B	HOH537

site_id	AC3
Number of Residues	23
Details	binding site for residue 9BG C 301

Chain	Residue
C	SER172
C	VAL173
C	TYR181
C	ILE184
C	LYS185
C	ARG212
C	ARG226
C	HOH407
C	HOH449
C	HOH453
C	HOH458
C	HOH526
D	SER43
D	TYR45
D	HIS46
D	GLN47
D	PHE48
D	ILE56
D	ARG93
D	ILE146
D	ARG147
D	SER153
D	HIS155

site_id	AC4
Number of Residues	26
Details	binding site for residue 9BG E 301

Chain	Residue
F	ARG147
F	SER153
F	HIS155
F	HOH462
F	HOH477
E	SER172
E	VAL173
E	TYR174
E	TYR181
E	ILE184
E	LYS185
E	LEU189
E	ARG212
E	ARG226
E	HOH451
E	HOH487
E	HOH489
E	HOH493
F	SER43
F	TYR45
F	HIS46
F	GLN47
F	PHE48
F	ILE56
F	ARG93
F	ILE146

site_id	AC5
Number of Residues	27
Details	binding site for residue 9BG F 301

Chain	Residue
E	TYR45
E	HIS46
E	GLN47
E	PHE48
E	ARG93
E	ILE146
E	ARG147
E	SER153
E	HIS155
E	HOH508
F	SER172
F	VAL173
F	TYR174
F	TYR181
F	ILE184
F	LYS185
F	ALA188
F	LEU189
F	ARG212
F	ARG226
F	HOH405
F	HOH442
F	HOH444
F	HOH455
F	HOH460
F	HOH476
F	HOH493

site_id	AC6
Number of Residues	25
Details	binding site for residue 9BG G 301

Chain	Residue
G	SER172
G	VAL173
G	TYR174
G	TYR181
G	LYS185
G	ALA188
G	LEU189
G	ARG212
G	ARG226
G	HOH412
G	HOH448
G	HOH454
G	HOH499
H	SER43
H	TYR45
H	HIS46
H	GLN47
H	PHE48
H	ARG93
H	ILE146
H	ARG147
H	SER153
H	HIS155
H	HOH313
H	HOH366

site_id	AC7
Number of Residues	26
Details	binding site for residue 9BG I 301

Chain	Residue
I	SER172
I	VAL173
I	TYR181
I	ILE184
I	LYS185
I	ALA188
I	LEU189
I	ARG212
I	ARG226
I	HOH428
I	HOH434
I	HOH437
I	HOH471
I	HOH494
I	HOH522
I	HOH545
J	SER43
J	HIS46
J	GLN47
J	PHE48
J	ARG93
J	ILE146
J	ARG147
J	SER153
J	HIS155
J	HOH530

site_id	AC8
Number of Residues	24
Details	binding site for residue 9BG J 301

Chain	Residue
I	SER43
I	HIS46
I	GLN47
I	PHE48
I	ARG93
I	ILE146
I	ARG147
I	SER153
I	HIS155
I	HOH472
J	SER172
J	VAL173
J	TYR181
J	ILE184
J	LYS185
J	ALA188
J	ARG212
J	HIS224
J	ARG226
J	HOH420
J	HOH429
J	HOH464
J	HOH473
J	HOH531

site_id	AC9
Number of Residues	26
Details	binding site for residue 9BG K 301

Chain	Residue
K	SER172
K	VAL173
K	TYR174
K	TYR181
K	ILE184
K	LYS185
K	ALA188
K	LEU189
K	ARG212
K	ARG226
K	HOH436
K	HOH438
K	HOH459
K	HOH487
K	HOH521
L	SER43
L	TYR45
L	HIS46
L	GLN47
L	PHE48
L	ARG93
L	ILE146
L	ARG147
L	SER153
L	HIS155
L	HOH370

site_id	AD1
Number of Residues	28
Details	binding site for residue 9BG M 301

Chain	Residue
M	SER172
M	VAL173
M	TYR174
M	TYR181
M	LYS185
M	ALA188
M	LEU189
M	ARG212
M	ARG226
M	HOH412
M	HOH454
M	HOH464
M	HOH467
M	HOH477
M	HOH478
M	HOH497
N	SER43
N	TYR45
N	HIS46
N	GLN47
N	PHE48
N	ILE56
N	ARG93
N	ILE146
N	ARG147
N	SER153
N	HIS155
N	HOH375

site_id	AD2
Number of Residues	24
Details	binding site for residue 9BG M 302

Chain	Residue
M	TYR45
M	HIS46
M	GLN47
M	PHE48
M	ARG93
M	ILE146
M	ARG147
M	SER153
M	HIS155
M	HOH406
M	HOH430
M	HOH456
M	HOH485
N	SER172
N	VAL173
N	TYR174
N	TYR181
N	ILE184
N	LYS185
N	ALA188
N	LEU189
N	ARG212
N	ARG226
N	HOH338

site_id	AD3
Number of Residues	24
Details	binding site for residue 9BG P 301

Chain	Residue
O	SER172
O	VAL173
O	TYR181
O	LYS185
O	ALA188
O	LEU189
O	ARG212
O	ARG226
O	HOH347
O	HOH374
P	TYR45
P	HIS46
P	GLN47
P	PHE48
P	ARG93
P	ILE146
P	ARG147
P	SER153
P	HIS155
P	HOH421
P	HOH429
P	HOH469
P	HOH481
P	HOH496

site_id	AD4
Number of Residues	24
Details	binding site for residue 9BG P 302

Chain	Residue
O	SER43
O	HIS46
O	GLN47
O	PHE48
O	ILE56
O	ARG93
O	ILE146
O	ARG147
O	SER153
O	HIS155
O	HOH360
P	SER172
P	VAL173
P	TYR181
P	LYS185
P	ALA188
P	LEU189
P	ARG212
P	HIS224
P	ARG226
P	HOH411
P	HOH458
P	HOH466
P	HOH521

site_id	AD5
Number of Residues	31
Details	binding site for Di-peptide 9BG C 302 and ARG C 93

Chain	Residue
C	TYR45
C	HIS46
C	GLN47
C	PHE48
C	VAL89
C	CYS90
C	ASN91
C	LYS92
C	PHE94
C	VAL95
C	ILE146
C	ARG147
C	SER153
C	HIS155
C	HOH415
C	HOH422
C	HOH445
C	HOH447
C	HOH488
C	HOH502
C	HOH507
D	SER172
D	VAL173
D	TYR181
D	ILE184
D	LYS185
D	ALA188
D	LEU189
D	ARG212
D	ARG226
D	HOH315

site_id	AD6
Number of Residues	28
Details	binding site for Di-peptide 9BG G 302 and ARG G 93

Chain	Residue
G	HIS46
G	GLN47
G	PHE48
G	VAL89
G	CYS90
G	ASN91
G	LYS92
G	PHE94
G	VAL95
G	ILE146
G	ARG147
G	SER153
G	HIS155
G	HOH403
G	HOH429
G	HOH442
G	HOH462
G	HOH463
G	HOH482
G	HOH522
H	SER172
H	VAL173
H	TYR181
H	LYS185
H	ALA188
H	LEU189
H	ARG212
H	ARG226

site_id	AD7
Number of Residues	28
Details	binding site for Di-peptide 9BG K 302 and ARG K 93

Chain	Residue
K	TYR45
K	HIS46
K	GLN47
K	PHE48
K	VAL89
K	CYS90
K	ASN91
K	LYS92
K	PHE94
K	VAL95
K	ILE146
K	ARG147
K	SER153
K	HIS155
K	HOH443
K	HOH475
K	HOH491
K	HOH496
L	SER172
L	VAL173
L	TYR174
L	TYR181
L	ILE184
L	LYS185
L	ALA188
L	LEU189
L	ARG212
L	ARG226

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_04143","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Active site: {"description":"Shared with catalytic histidine of dimeric partner","evidences":[{"source":"HAMAP-Rule","id":"MF_04143","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	16
Details	Active site: {"description":"Proton acceptor; shared with catalytic histidine of dimeric partner","evidences":[{"source":"HAMAP-Rule","id":"MF_04143","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	48
Details	Site: {"description":"Substrate binding","evidences":[{"source":"HAMAP-Rule","id":"MF_04143","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)