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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6XAS

CryoEM Structure of E. coli Rho-dependent Transcription Pre-termination Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003676molecular_functionnucleic acid binding
A0003723molecular_functionRNA binding
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005829cellular_componentcytosol
A0006353biological_processDNA-templated transcription termination
A0008186molecular_functionATP-dependent activity, acting on RNA
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0042802molecular_functionidentical protein binding
B0000166molecular_functionnucleotide binding
B0003676molecular_functionnucleic acid binding
B0003723molecular_functionRNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005829cellular_componentcytosol
B0006353biological_processDNA-templated transcription termination
B0008186molecular_functionATP-dependent activity, acting on RNA
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0042802molecular_functionidentical protein binding
C0000166molecular_functionnucleotide binding
C0003676molecular_functionnucleic acid binding
C0003723molecular_functionRNA binding
C0004386molecular_functionhelicase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005829cellular_componentcytosol
C0006353biological_processDNA-templated transcription termination
C0008186molecular_functionATP-dependent activity, acting on RNA
C0016020cellular_componentmembrane
C0016787molecular_functionhydrolase activity
C0042802molecular_functionidentical protein binding
D0000166molecular_functionnucleotide binding
D0003676molecular_functionnucleic acid binding
D0003723molecular_functionRNA binding
D0004386molecular_functionhelicase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005829cellular_componentcytosol
D0006353biological_processDNA-templated transcription termination
D0008186molecular_functionATP-dependent activity, acting on RNA
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0042802molecular_functionidentical protein binding
E0000166molecular_functionnucleotide binding
E0003676molecular_functionnucleic acid binding
E0003723molecular_functionRNA binding
E0004386molecular_functionhelicase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005829cellular_componentcytosol
E0006353biological_processDNA-templated transcription termination
E0008186molecular_functionATP-dependent activity, acting on RNA
E0016020cellular_componentmembrane
E0016787molecular_functionhydrolase activity
E0042802molecular_functionidentical protein binding
F0000166molecular_functionnucleotide binding
F0003676molecular_functionnucleic acid binding
F0003723molecular_functionRNA binding
F0004386molecular_functionhelicase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005829cellular_componentcytosol
F0006353biological_processDNA-templated transcription termination
F0008186molecular_functionATP-dependent activity, acting on RNA
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0042802molecular_functionidentical protein binding
G0000166molecular_functionnucleotide binding
G0001000molecular_functionbacterial-type RNA polymerase core enzyme binding
G0003676molecular_functionnucleic acid binding
G0003700molecular_functionDNA-binding transcription factor activity
G0003723molecular_functionRNA binding
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006353biological_processDNA-templated transcription termination
G0008023cellular_componenttranscription elongation factor complex
G0019904molecular_functionprotein domain specific binding
G0031554biological_processregulation of termination of DNA-templated transcription
G0031564biological_processtranscription antitermination
G0032784biological_processregulation of DNA-templated transcription elongation
G0042254biological_processribosome biogenesis
G0051259biological_processprotein complex oligomerization
H0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
H0000428cellular_componentDNA-directed RNA polymerase complex
H0003677molecular_functionDNA binding
H0003899molecular_functionDNA-directed RNA polymerase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006351biological_processDNA-templated transcription
H0006352biological_processDNA-templated transcription initiation
H0006879biological_processintracellular iron ion homeostasis
H0008023cellular_componenttranscription elongation factor complex
H0009408biological_processresponse to heat
H0016020cellular_componentmembrane
H0016740molecular_functiontransferase activity
H0016779molecular_functionnucleotidyltransferase activity
H0031564biological_processtranscription antitermination
H0032784biological_processregulation of DNA-templated transcription elongation
H0034062molecular_function5'-3' RNA polymerase activity
H0036460biological_processcellular response to cell envelope stress
H0042128biological_processnitrate assimilation
H0044780biological_processbacterial-type flagellum assembly
H0046983molecular_functionprotein dimerization activity
H0048870biological_processcell motility
H0071973biological_processbacterial-type flagellum-dependent cell motility
H0090605biological_processsubmerged biofilm formation
H2000142biological_processregulation of DNA-templated transcription initiation
I0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
I0000428cellular_componentDNA-directed RNA polymerase complex
I0003677molecular_functionDNA binding
I0003899molecular_functionDNA-directed RNA polymerase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006351biological_processDNA-templated transcription
I0006352biological_processDNA-templated transcription initiation
I0006879biological_processintracellular iron ion homeostasis
I0008023cellular_componenttranscription elongation factor complex
I0009408biological_processresponse to heat
I0016020cellular_componentmembrane
I0016740molecular_functiontransferase activity
I0016779molecular_functionnucleotidyltransferase activity
I0031564biological_processtranscription antitermination
I0032549molecular_functionribonucleoside binding
I0032784biological_processregulation of DNA-templated transcription elongation
I0034062molecular_function5'-3' RNA polymerase activity
I0036460biological_processcellular response to cell envelope stress
I0042128biological_processnitrate assimilation
I0044780biological_processbacterial-type flagellum assembly
I0046677biological_processresponse to antibiotic
I0048870biological_processcell motility
I0071973biological_processbacterial-type flagellum-dependent cell motility
I0090605biological_processsubmerged biofilm formation
I2000142biological_processregulation of DNA-templated transcription initiation
J0000287molecular_functionmagnesium ion binding
J0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
J0000428cellular_componentDNA-directed RNA polymerase complex
J0003677molecular_functionDNA binding
J0003899molecular_functionDNA-directed RNA polymerase activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006351biological_processDNA-templated transcription
J0006352biological_processDNA-templated transcription initiation
J0006879biological_processintracellular iron ion homeostasis
J0008023cellular_componenttranscription elongation factor complex
J0008270molecular_functionzinc ion binding
J0009408biological_processresponse to heat
J0016020cellular_componentmembrane
J0016740molecular_functiontransferase activity
J0016779molecular_functionnucleotidyltransferase activity
J0031564biological_processtranscription antitermination
J0032784biological_processregulation of DNA-templated transcription elongation
J0034062molecular_function5'-3' RNA polymerase activity
J0036460biological_processcellular response to cell envelope stress
J0042128biological_processnitrate assimilation
J0044780biological_processbacterial-type flagellum assembly
J0046677biological_processresponse to antibiotic
J0046872molecular_functionmetal ion binding
J0048870biological_processcell motility
J0071973biological_processbacterial-type flagellum-dependent cell motility
J0090605biological_processsubmerged biofilm formation
J2000142biological_processregulation of DNA-templated transcription initiation
K0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
K0000428cellular_componentDNA-directed RNA polymerase complex
K0003677molecular_functionDNA binding
K0003899molecular_functionDNA-directed RNA polymerase activity
K0005515molecular_functionprotein binding
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0006351biological_processDNA-templated transcription
K0006352biological_processDNA-templated transcription initiation
K0006879biological_processintracellular iron ion homeostasis
K0008023cellular_componenttranscription elongation factor complex
K0009408biological_processresponse to heat
K0016020cellular_componentmembrane
K0016740molecular_functiontransferase activity
K0016779molecular_functionnucleotidyltransferase activity
K0031564biological_processtranscription antitermination
K0032784biological_processregulation of DNA-templated transcription elongation
K0034062molecular_function5'-3' RNA polymerase activity
K0036460biological_processcellular response to cell envelope stress
K0042128biological_processnitrate assimilation
K0044780biological_processbacterial-type flagellum assembly
K0046983molecular_functionprotein dimerization activity
K0048870biological_processcell motility
K0071973biological_processbacterial-type flagellum-dependent cell motility
K0090605biological_processsubmerged biofilm formation
K2000142biological_processregulation of DNA-templated transcription initiation
W0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
W0000428cellular_componentDNA-directed RNA polymerase complex
W0001000molecular_functionbacterial-type RNA polymerase core enzyme binding
W0003677molecular_functionDNA binding
W0003899molecular_functionDNA-directed RNA polymerase activity
W0005829cellular_componentcytosol
W0006351biological_processDNA-templated transcription
W0006352biological_processDNA-templated transcription initiation
W0006879biological_processintracellular iron ion homeostasis
W0008023cellular_componenttranscription elongation factor complex
W0009408biological_processresponse to heat
W0016740molecular_functiontransferase activity
W0016779molecular_functionnucleotidyltransferase activity
W0030880cellular_componentRNA polymerase complex
W0031564biological_processtranscription antitermination
W0032784biological_processregulation of DNA-templated transcription elongation
W0034062molecular_function5'-3' RNA polymerase activity
W0036460biological_processcellular response to cell envelope stress
W0042128biological_processnitrate assimilation
W0044780biological_processbacterial-type flagellum assembly
W0048870biological_processcell motility
W0065003biological_processprotein-containing complex assembly
W0071973biological_processbacterial-type flagellum-dependent cell motility
W0090605biological_processsubmerged biofilm formation
W2000142biological_processregulation of DNA-templated transcription initiation
Functional Information from PROSITE/UniProt
site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGV
ChainResidueDetails
IGLY1063-VAL1075
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues65
DetailsDomain: {"description":"S1 motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00945","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues136
DetailsRegion: {"description":"N-terminal domain (NTD) interacts with RNAP","evidences":[{"source":"PubMed","id":"21922055","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsRegion: {"description":"Required for interaction with Crp at class II promoters"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"ADP-ribosylarginine","evidences":[{"source":"PubMed","id":"4371081","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21696463","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine; by PatZ","evidences":[{"source":"PubMed","id":"21696463","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues11
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32871103","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MEX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MEY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues450
DetailsDomain: {"description":"Rho RNA-BD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01203","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues54
DetailsRegion: {"description":"RNA-binding 1"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues24
DetailsRegion: {"description":"RNA-binding 2"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues30
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues36
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues6
DetailsSite: {"description":"RNA-binding 2"}
ChainResidueDetails

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PDB entries from 2025-07-16

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