Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6X86

Crystal Structure of TNFalpha with indolinone compound 11

Functional Information from GO Data
ChainGOidnamespacecontents
A0005164molecular_functiontumor necrosis factor receptor binding
A0006955biological_processimmune response
A0016020cellular_componentmembrane
B0005164molecular_functiontumor necrosis factor receptor binding
B0006955biological_processimmune response
B0016020cellular_componentmembrane
C0005164molecular_functiontumor necrosis factor receptor binding
C0006955biological_processimmune response
C0016020cellular_componentmembrane
D0005164molecular_functiontumor necrosis factor receptor binding
D0006955biological_processimmune response
D0016020cellular_componentmembrane
E0005164molecular_functiontumor necrosis factor receptor binding
E0006955biological_processimmune response
E0016020cellular_componentmembrane
F0005164molecular_functiontumor necrosis factor receptor binding
F0006955biological_processimmune response
F0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue UTY B 901
ChainResidue
ALEU57
BGLY122
BTYR151
BILE155
CLYS11
CLEU57
CTYR119
CGLY121
CGLY122
CLEU157
ATYR119
AILE155
ALEU157
BLEU57
BTYR59
BSER60
BLEU120
BGLY121

site_idAC2
Number of Residues16
Detailsbinding site for residue UTY F 201
ChainResidue
DLYS11
DLEU57
DTYR119
DILE155
ELEU57
ETYR59
ELEU120
EGLY121
EGLY122
ETYR151
EILE155
FLYS11
FLEU57
FTYR59
FTYR119
FGLY122

Functional Information from PROSITE/UniProt
site_idPS00251
Number of Residues17
DetailsTNF_1 TNF family signature. LvVPsEGLYLIysQVlF
ChainResidueDetails
ALEU48-PHE64

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsCARBOHYD: O-linked (GalNAc...) serine; in soluble form => ECO:0000269|PubMed:8631363
ChainResidueDetails
BSER4
CSER4
DSER4
ESER4
FSER4
ASER4

220472

PDB entries from 2024-05-29

PDB statisticsPDBj update infoContact PDBjnumon