6X6A
Cryo-EM structure of NLRP1-DPP9 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005874 | cellular_component | microtubule |
| A | 0006508 | biological_process | proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| A | 0031252 | cellular_component | cell leading edge |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043069 | biological_process | negative regulation of programmed cell death |
| A | 0070269 | biological_process | pyroptotic inflammatory response |
| C | 0006954 | biological_process | inflammatory response |
| C | 0042981 | biological_process | regulation of apoptotic process |
| C | 0045087 | biological_process | innate immune response |
| D | 0004177 | molecular_function | aminopeptidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005874 | cellular_component | microtubule |
| D | 0006508 | biological_process | proteolysis |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| D | 0031252 | cellular_component | cell leading edge |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0043069 | biological_process | negative regulation of programmed cell death |
| D | 0070269 | biological_process | pyroptotic inflammatory response |
| F | 0006954 | biological_process | inflammatory response |
| F | 0042981 | biological_process | regulation of apoptotic process |
| F | 0045087 | biological_process | innate immune response |
| G | 0006954 | biological_process | inflammatory response |
| G | 0042981 | biological_process | regulation of apoptotic process |
| G | 0045087 | biological_process | innate immune response |
| I | 0006954 | biological_process | inflammatory response |
| I | 0042981 | biological_process | regulation of apoptotic process |
| I | 0045087 | biological_process | innate immune response |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00136 |
| Chain | Residue | Details |
| B | GLY334 | |
| E | GLY334 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: (Microbial infection) Cleavage; by human rhinovirus 14 (HRV-14) Protease 3C => ECO:0000269|PubMed:33093214, ECO:0000269|PubMed:33410748 |
| Chain | Residue | Details |
| B | GLN130 | |
| E | GLN130 | |
| D | ASP808 | |
| D | HIS840 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: (Microbial infection) Cleavage; by coronavirus SARS-CoV-2 proteinase nsp5 => ECO:0000269|PubMed:35594856 |
| Chain | Residue | Details |
| B | GLN333 | |
| E | GLN333 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by autolysis => ECO:0000255|PROSITE-ProRule:PRU01174, ECO:0000269|PubMed:22665479 |
| Chain | Residue | Details |
| B | PHE1212 | |
| E | PHE1212 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine; by MAPK11 and MAPK14 => ECO:0000269|PubMed:35857590 |
| Chain | Residue | Details |
| B | SER93 | |
| B | SER99 | |
| B | SER101 | |
| B | SER170 | |
| E | SER93 | |
| E | SER99 | |
| E | SER101 | |
| E | SER170 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by MAPK14 => ECO:0000269|PubMed:35857590 |
| Chain | Residue | Details |
| B | SER107 | |
| B | SER163 | |
| E | SER107 | |
| E | SER163 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by MAPK11, MAPK14 and MAP3K20 => ECO:0000269|PubMed:35857590 |
| Chain | Residue | Details |
| B | THR112 | |
| E | THR112 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by MAP3K20 => ECO:0000269|PubMed:35857590 |
| Chain | Residue | Details |
| B | SER113 | |
| B | SER132 | |
| E | SER113 | |
| E | SER132 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by MAP3K20 => ECO:0000269|PubMed:35857590 |
| Chain | Residue | Details |
| B | THR114 | |
| B | THR129 | |
| E | THR114 | |
| E | THR129 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAPK11 and MAPk14 => ECO:0000269|PubMed:35857590 |
| Chain | Residue | Details |
| B | SER168 | |
| E | SER168 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAPK11 => ECO:0000269|PubMed:35857590 |
| Chain | Residue | Details |
| B | SER173 | |
| E | SER173 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by MAPK11 => ECO:0000269|PubMed:35857590 |
| Chain | Residue | Details |
| B | THR178 | |
| E | THR178 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAPK11 and MAP3K20 => ECO:0000269|PubMed:35857590 |
| Chain | Residue | Details |
| B | SER179 | |
| E | SER179 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by MAPK11 and MAP3K20 => ECO:0000269|PubMed:35857590 |
| Chain | Residue | Details |
| B | THR180 | |
| E | THR180 |
