6X6A

Cryo-EM structure of NLRP1-DPP9 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004177	molecular_function	aminopeptidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005874	cellular_component	microtubule
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0008239	molecular_function	dipeptidyl-peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0031252	cellular_component	cell leading edge
A	0042802	molecular_function	identical protein binding
A	0043069	biological_process	negative regulation of programmed cell death
A	0051604	biological_process	protein maturation
A	0070269	biological_process	pyroptotic inflammatory response
A	0140633	biological_process	CARD8 inflammasome complex assembly
A	0141201	biological_process	pyroptotic cell death
A	1904784	biological_process	NLRP1 inflammasome complex assembly
C	0006954	biological_process	inflammatory response
C	0042981	biological_process	regulation of apoptotic process
C	0045087	biological_process	innate immune response
D	0004177	molecular_function	aminopeptidase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005874	cellular_component	microtubule
D	0006508	biological_process	proteolysis
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0008239	molecular_function	dipeptidyl-peptidase activity
D	0016787	molecular_function	hydrolase activity
D	0031252	cellular_component	cell leading edge
D	0042802	molecular_function	identical protein binding
D	0043069	biological_process	negative regulation of programmed cell death
D	0051604	biological_process	protein maturation
D	0070269	biological_process	pyroptotic inflammatory response
D	0140633	biological_process	CARD8 inflammasome complex assembly
D	0141201	biological_process	pyroptotic cell death
D	1904784	biological_process	NLRP1 inflammasome complex assembly
F	0006954	biological_process	inflammatory response
F	0042981	biological_process	regulation of apoptotic process
F	0045087	biological_process	innate immune response
G	0006954	biological_process	inflammatory response
G	0042981	biological_process	regulation of apoptotic process
G	0045087	biological_process	innate immune response
I	0006954	biological_process	inflammatory response
I	0042981	biological_process	regulation of apoptotic process
I	0045087	biological_process	innate immune response

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"30291141","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"Q6V1X1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"33731932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34019797","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JN7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	266
Details	Region: {"description":"ZU5","evidences":[{"source":"PubMed","id":"22087307","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

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