6X6A
Cryo-EM structure of NLRP1-DPP9 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005874 | cellular_component | microtubule |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0031252 | cellular_component | cell leading edge |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043069 | biological_process | negative regulation of programmed cell death |
| A | 0070269 | biological_process | pyroptotic inflammatory response |
| C | 0006954 | biological_process | inflammatory response |
| C | 0042981 | biological_process | regulation of apoptotic process |
| C | 0045087 | biological_process | innate immune response |
| D | 0004177 | molecular_function | aminopeptidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005829 | cellular_component | cytosol |
| D | 0005874 | cellular_component | microtubule |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0031252 | cellular_component | cell leading edge |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0043069 | biological_process | negative regulation of programmed cell death |
| D | 0070269 | biological_process | pyroptotic inflammatory response |
| F | 0006954 | biological_process | inflammatory response |
| F | 0042981 | biological_process | regulation of apoptotic process |
| F | 0045087 | biological_process | innate immune response |
| G | 0006954 | biological_process | inflammatory response |
| G | 0042981 | biological_process | regulation of apoptotic process |
| G | 0045087 | biological_process | innate immune response |
| I | 0006954 | biological_process | inflammatory response |
| I | 0042981 | biological_process | regulation of apoptotic process |
| I | 0045087 | biological_process | innate immune response |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"30291141","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"Q6V1X1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"33731932","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34019797","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7JN7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 266 |
| Details | Region: {"description":"ZU5","evidences":[{"source":"PubMed","id":"22087307","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
