6X2Z
hEAAT3-OFS-Asp
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005313 | molecular_function | L-glutamate transmembrane transporter activity |
| A | 0005314 | molecular_function | high-affinity L-glutamate transmembrane transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006836 | biological_process | neurotransmitter transport |
| A | 0006865 | biological_process | amino acid transport |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0010460 | biological_process | positive regulation of heart rate |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015183 | molecular_function | L-aspartate transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015501 | molecular_function | glutamate:sodium symporter activity |
| A | 0015813 | biological_process | L-glutamate transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0031902 | cellular_component | late endosome membrane |
| A | 0032279 | cellular_component | asymmetric synapse |
| A | 0033229 | molecular_function | L-cysteine transmembrane transporter activity |
| A | 0035633 | biological_process | maintenance of blood-brain barrier |
| A | 0042883 | biological_process | L-cysteine transport |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043083 | cellular_component | synaptic cleft |
| A | 0043197 | cellular_component | dendritic spine |
| A | 0043198 | cellular_component | dendritic shaft |
| A | 0043204 | cellular_component | perikaryon |
| A | 0043679 | cellular_component | axon terminus |
| A | 0045177 | cellular_component | apical part of cell |
| A | 0045202 | cellular_component | synapse |
| A | 0048514 | biological_process | blood vessel morphogenesis |
| A | 0051938 | biological_process | L-glutamate import |
| A | 0055037 | cellular_component | recycling endosome |
| A | 0055038 | cellular_component | recycling endosome membrane |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070633 | biological_process | transepithelial transport |
| A | 0070777 | biological_process | D-aspartate transmembrane transport |
| A | 0070778 | biological_process | L-aspartate transmembrane transport |
| A | 0070779 | biological_process | D-aspartate import across plasma membrane |
| A | 0071407 | biological_process | obsolete cellular response to organic cyclic compound |
| A | 0071944 | cellular_component | cell periphery |
| A | 0097386 | cellular_component | glial cell projection |
| A | 0097440 | cellular_component | apical dendrite |
| A | 0098657 | biological_process | import into cell |
| A | 0098712 | biological_process | L-glutamate import across plasma membrane |
| A | 0098793 | cellular_component | presynapse |
| A | 0099544 | cellular_component | perisynaptic space |
| A | 0140009 | biological_process | L-aspartate import across plasma membrane |
| A | 0140010 | molecular_function | D-aspartate transmembrane transporter activity |
| A | 0150002 | cellular_component | distal dendrite |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1903712 | biological_process | L-cysteine transmembrane transport |
| A | 1990635 | cellular_component | proximal dendrite |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue ASP A 600 |
| Chain | Residue |
| A | SER331 |
| A | THR448 |
| A | ASN451 |
| A | SER332 |
| A | SER333 |
| A | MET367 |
| A | THR370 |
| A | GLY410 |
| A | VAL411 |
| A | ASP444 |
| A | ARG447 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 601 |
| Chain | Residue |
| A | GLY362 |
| A | ALA363 |
| A | ASN366 |
| A | ASN451 |
| A | ASP455 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 602 |
| Chain | Residue |
| A | THR364 |
| A | MET367 |
| A | SER405 |
| A | ILE406 |
| A | ALA408 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 603 |
| Chain | Residue |
| A | TYR98 |
| A | THR101 |
| A | THR102 |
| A | ASN366 |
| A | ASP368 |
Functional Information from PROSITE/UniProt
| site_id | PS00713 |
| Number of Residues | 15 |
| Details | NA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. P.GEiLMrMLKLIIlP |
| Chain | Residue | Details |
| A | PRO55-PRO69 |
| site_id | PS00714 |
| Number of Residues | 24 |
| Details | NA_DICARBOXYL_SYMP_2 Sodium:dicarboxylate symporter family signature 2. PvGaTiNMDGTaLYeaVaaVFIAQ |
| Chain | Residue | Details |
| A | PRO360-GLN383 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 59 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 65 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 63 |
| Details | Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 13 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33658209","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6X2Z","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33658209","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6X2Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6X3E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33658209","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6X3E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
