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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6X2J

Structure of human TRPA1 in complex with agonist GNE551

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ULJ A 1101

Chain	Residue
A	SER887
D	MET844
D	LEU848
D	LEU867
A	ALA939
A	GLN940
A	SER943
A	PHE947
D	ILE803
D	ALA836
D	TYR840
D	PHE841

site_id	AC2
Number of Residues	12
Details	binding site for residue ULJ B 1101

Chain	Residue
A	ILE803
A	ALA836
A	TYR840
A	PHE841
A	MET844
A	LEU848
A	LEU867
B	SER887
B	ALA939
B	GLN940
B	SER943
B	PHE947

site_id	AC3
Number of Residues	12
Details	binding site for residue ULJ C 1101

Chain	Residue
B	ILE803
B	ALA836
B	TYR840
B	PHE841
B	MET844
B	LEU848
B	LEU867
C	SER887
C	ALA939
C	GLN940
C	SER943
C	PHE947

site_id	AC4
Number of Residues	11
Details	binding site for residue ULJ D 1101

Chain	Residue
C	ILE803
C	ALA836
C	TYR840
C	PHE841
C	MET844
C	LEU848
D	SER887
D	ALA939
D	GLN940
D	SER943
D	PHE947

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DISDTRLLNegDL

Chain	Residue	Details
A	ASP468-LEU480

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	HIS719-ASN739
B	HIS719-ASN739
C	HIS719-ASN739
D	HIS719-ASN739

site_id	SWS_FT_FI2
Number of Residues	200
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	ILE740-SER767
C	VAL824-HIS829
C	ASN893-PRO901
C	LEU923-HIS933
D	ILE740-SER767
D	VAL824-HIS829
D	ASN893-PRO901
D	LEU923-HIS933
A	VAL824-HIS829
A	ASN893-PRO901
A	LEU923-HIS933
B	ILE740-SER767
B	VAL824-HIS829
B	ASN893-PRO901
B	LEU923-HIS933
C	ILE740-SER767

site_id	SWS_FT_FI3
Number of Residues	100
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	TYR768-PHE793
B	TYR768-PHE793
C	TYR768-PHE793
D	TYR768-PHE793

site_id	SWS_FT_FI4
Number of Residues	60
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	GLN794-ASN798
A	GLN851-MET862
B	GLN794-ASN798
B	GLN851-MET862
C	GLN794-ASN798
C	GLN851-MET862
D	GLN794-ASN798
D	GLN851-MET862

site_id	SWS_FT_FI5
Number of Residues	96
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	TYR799-PHE823
B	TYR799-PHE823
C	TYR799-PHE823
D	TYR799-PHE823

site_id	SWS_FT_FI6
Number of Residues	80
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	LEU830-LEU850
B	LEU830-LEU850
C	LEU830-LEU850
D	LEU830-LEU850

site_id	SWS_FT_FI7
Number of Residues	116
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	LEU863-LEU892
B	LEU863-LEU892
C	LEU863-LEU892
D	LEU863-LEU892

site_id	SWS_FT_FI8
Number of Residues	80
Details	INTRAMEM: Pore-forming => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	LEU902-PHE922
B	LEU902-PHE922
C	LEU902-PHE922
D	LEU902-PHE922

site_id	SWS_FT_FI9
Number of Residues	104
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:31866091, ECO:0007744\|PDB:6PQO

Chain	Residue	Details
A	PRO934-ALA960
B	PRO934-ALA960
C	PRO934-ALA960
D	PRO934-ALA960

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: covalent; Cys highly reactive => ECO:0000250\|UniProtKB:Q8BLA8, ECO:0000305\|PubMed:17164327, ECO:0000305\|PubMed:27241698

Chain	Residue	Details
A	CYS621
B	CYS621
C	CYS621
D	CYS621

site_id	SWS_FT_FI11
Number of Residues	8
Details	BINDING: covalent => ECO:0000305\|PubMed:17164327

Chain	Residue	Details
A	CYS641
A	LYS710
B	CYS641
B	LYS710
C	CYS641
C	LYS710
D	CYS641
D	LYS710

site_id	SWS_FT_FI12
Number of Residues	4
Details	BINDING: covalent => ECO:0000305\|PubMed:17164327, ECO:0000305\|PubMed:27241698

Chain	Residue	Details
A	CYS665
B	CYS665
C	CYS665
D	CYS665

site_id	SWS_FT_FI13
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:32641835, ECO:0007744\|PDB:6V9V

Chain	Residue	Details
A	GLU788
C	GLN791
C	ASN805
C	GLU808
D	GLU788
D	GLN791
D	ASN805
D	GLU808
A	GLN791
A	ASN805
A	GLU808
B	GLU788
B	GLN791
B	ASN805
B	GLU808
C	GLU788

site_id	SWS_FT_FI14
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305\|PubMed:25855297

Chain	Residue	Details
A	LYS1046
B	LYS1046
C	LYS1046
D	LYS1046

site_id	SWS_FT_FI15
Number of Residues	4
Details	SITE: Required for C-621 reactivity => ECO:0000269\|PubMed:27241698

Chain	Residue	Details
A	LYS620
B	LYS620
C	LYS620
D	LYS620

site_id	SWS_FT_FI16
Number of Residues	4
Details	SITE: Essential for electrophile activation. Sensor for electrophilic agents => ECO:0000269\|PubMed:31866091, ECO:0000269\|PubMed:32641835

Chain	Residue	Details
A	CYS621
B	CYS621
C	CYS621
D	CYS621

site_id	SWS_FT_FI17
Number of Residues	4
Details	SITE: Key residue for activation by the scorpion wasabi receptor toxin => ECO:0000269\|PubMed:31447178

Chain	Residue	Details
A	PRO622
B	PRO622
C	PRO622
D	PRO622

site_id	SWS_FT_FI18
Number of Residues	8
Details	SITE: Important residue for activation by the scorpion wasabi receptor toxin => ECO:0000269\|PubMed:31447178

Chain	Residue	Details
A	MET634
A	THR646
B	MET634
B	THR646
C	MET634
C	THR646
D	MET634
D	THR646

site_id	SWS_FT_FI19
Number of Residues	4
Details	SITE: Important for electrophile activation => ECO:0000269\|PubMed:31866091, ECO:0000269\|PubMed:32641835

Chain	Residue	Details
A	CYS665
B	CYS665
C	CYS665
D	CYS665

site_id	SWS_FT_FI20
Number of Residues	4
Details	SITE: Crucial for calcium permeation => ECO:0000250\|UniProtKB:Q6RI86

Chain	Residue	Details
A	ASP915
B	ASP915
C	ASP915
D	ASP915

site_id	SWS_FT_FI21
Number of Residues	8
Details	MOD_RES: Cysteine sulfenic acid (-SOH); transient; in hyperoxia => ECO:0000305\|PubMed:21873995

Chain	Residue	Details
A	CYS633
A	CYS856
B	CYS633
B	CYS856
C	CYS633
C	CYS856
D	CYS633
D	CYS856

site_id	SWS_FT_FI22
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN747
A	ASN753
B	ASN747
B	ASN753
C	ASN747
C	ASN753
D	ASN747
D	ASN753

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PDB entries from 2024-09-25

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