6X2E
Crystal Structure of Chlamydia trachomatis mixed (apo/holo) Glyceraldehyde 3-phosphate dehydrogenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006006 | biological_process | glucose metabolic process |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0050661 | molecular_function | NADP binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004365 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006006 | biological_process | glucose metabolic process |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0050661 | molecular_function | NADP binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | binding site for residue NAD A 400 |
| Chain | Residue |
| A | GLY7 |
| A | GLY97 |
| A | LEU98 |
| A | THR119 |
| A | ALA120 |
| A | CYS150 |
| A | ALA181 |
| A | ASN314 |
| A | TYR318 |
| A | HOH529 |
| A | HOH531 |
| A | PHE8 |
| A | HOH534 |
| A | HOH549 |
| A | HOH553 |
| A | HOH556 |
| A | HOH578 |
| A | HOH585 |
| A | HOH592 |
| A | HOH628 |
| A | HOH659 |
| C | HOH546 |
| A | GLY9 |
| A | ARG10 |
| A | ILE11 |
| A | ASP33 |
| A | LEU34 |
| A | SER95 |
| A | THR96 |
| site_id | AC2 |
| Number of Residues | 32 |
| Details | binding site for residue NAD C 400 |
| Chain | Residue |
| C | GLY7 |
| C | PHE8 |
| C | GLY9 |
| C | ARG10 |
| C | ILE11 |
| C | ASN32 |
| C | ASP33 |
| C | LEU34 |
| C | LYS77 |
| C | SER95 |
| C | THR96 |
| C | GLY97 |
| C | LEU98 |
| C | THR119 |
| C | ALA120 |
| C | ALA181 |
| C | ASN314 |
| C | TYR318 |
| C | HOH507 |
| C | HOH526 |
| C | HOH537 |
| C | HOH552 |
| C | HOH568 |
| C | HOH575 |
| C | HOH578 |
| C | HOH579 |
| C | HOH583 |
| C | HOH589 |
| C | HOH597 |
| C | HOH599 |
| C | HOH637 |
| C | HOH643 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | binding site for residue NAD D 400 |
| Chain | Residue |
| D | GLY7 |
| D | PHE8 |
| D | GLY9 |
| D | ARG10 |
| D | ILE11 |
| D | ASP33 |
| D | LEU34 |
| D | SER95 |
| D | THR96 |
| D | GLY97 |
| D | LEU98 |
| D | THR119 |
| D | ALA120 |
| D | CYS150 |
| D | ALA181 |
| D | ASN314 |
| D | TYR318 |
| D | HOH527 |
| D | HOH543 |
| D | HOH547 |
| D | HOH556 |
| D | HOH568 |
| D | HOH624 |
Functional Information from PROSITE/UniProt
| site_id | PS00071 |
| Number of Residues | 8 |
| Details | GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL |
| Chain | Residue | Details |
| A | ALA148-LEU155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P00362 |
| Chain | Residue | Details |
| A | CYS150 | |
| B | CYS150 | |
| C | CYS150 | |
| D | CYS150 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00362 |
| Chain | Residue | Details |
| A | ARG10 | |
| B | ARG10 | |
| B | ASP33 | |
| B | LYS77 | |
| B | THR119 | |
| B | SER149 | |
| B | THR180 | |
| B | THR209 | |
| B | ARG232 | |
| B | ASN314 | |
| C | ARG10 | |
| A | ASP33 | |
| C | ASP33 | |
| C | LYS77 | |
| C | THR119 | |
| C | SER149 | |
| C | THR180 | |
| C | THR209 | |
| C | ARG232 | |
| C | ASN314 | |
| D | ARG10 | |
| D | ASP33 | |
| A | LYS77 | |
| D | LYS77 | |
| D | THR119 | |
| D | SER149 | |
| D | THR180 | |
| D | THR209 | |
| D | ARG232 | |
| D | ASN314 | |
| A | THR119 | |
| A | SER149 | |
| A | THR180 | |
| A | THR209 | |
| A | ARG232 | |
| A | ASN314 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Activates thiol group during catalysis => ECO:0000250|UniProtKB:P00362 |
| Chain | Residue | Details |
| A | HIS177 | |
| B | HIS177 | |
| C | HIS177 | |
| D | HIS177 |
