Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004322 | molecular_function | ferroxidase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005764 | cellular_component | lysosome |
| A | 0005776 | cellular_component | autophagosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006826 | biological_process | iron ion transport |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0006880 | biological_process | intracellular sequestering of iron ion |
| A | 0006955 | biological_process | immune response |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0008199 | molecular_function | ferric iron binding |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044754 | cellular_component | autolysosome |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048147 | biological_process | negative regulation of fibroblast proliferation |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070288 | cellular_component | ferritin complex |
| A | 0110076 | biological_process | negative regulation of ferroptosis |
| A | 0140315 | molecular_function | iron ion sequestering activity |
| A | 1904724 | cellular_component | tertiary granule lumen |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue RFT A 201 |
| Chain | Residue |
| A | CYS157 |
| A | HOH305 |
| A | HOH312 |
| A | HOH428 |
| A | HOH452 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue CA A 202 |
| Chain | Residue |
| A | CA212 |
| A | CA212 |
| A | HOH532 |
| A | HOH532 |
| A | ASP84 |
| A | ASP84 |
| A | GLN86 |
| A | GLN86 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 203 |
| Chain | Residue |
| A | HIS173 |
| A | HIS173 |
| A | HIS173 |
| A | HIS173 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 204 |
| Chain | Residue |
| A | GLN14 |
| A | HOH505 |
| A | HOH553 |
| A | HOH558 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue CA A 205 |
| Chain | Residue |
| A | CA206 |
| A | CA206 |
| A | HOH414 |
| A | HOH414 |
| A | HOH420 |
| A | HOH420 |
| A | HOH602 |
| A | HOH602 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue CA A 206 |
| Chain | Residue |
| A | CA205 |
| A | CA205 |
| A | HOH337 |
| A | HOH337 |
| A | HOH414 |
| A | HOH414 |
| A | HOH443 |
| A | HOH443 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 207 |
| Chain | Residue |
| A | ARG9 |
| A | ASN11 |
| A | TYR12 |
| A | HOH526 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue CA A 208 |
| Chain | Residue |
| A | HOH337 |
| A | HOH337 |
| A | HOH413 |
| A | HOH413 |
| A | HOH464 |
| A | HOH464 |
| A | HOH493 |
| A | HOH493 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 209 |
| Chain | Residue |
| A | ALA18 |
| A | ASN21 |
| A | HOH329 |
| A | HOH512 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue CA A 210 |
| Chain | Residue |
| A | ASP131 |
| A | ASP131 |
| A | ASP131 |
| A | GLU134 |
| A | GLU134 |
| A | GLU134 |
| A | HOH322 |
| A | HOH322 |
| A | HOH322 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 211 |
| Chain | Residue |
| A | ASN25 |
| A | GLN83 |
| A | HOH533 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue CA A 212 |
| Chain | Residue |
| A | ASP84 |
| A | ASP84 |
| A | GLN86 |
| A | GLN86 |
| A | CA202 |
| A | CA202 |
| A | HOH532 |
| A | HOH532 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue FE A 213 |
| Chain | Residue |
| A | GLU27 |
| A | GLU62 |
| A | HIS65 |
| A | GLN141 |
| A | FE214 |
| A | HOH345 |
| A | HOH418 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue FE A 214 |
| Chain | Residue |
| A | GLU62 |
| A | GLU107 |
| A | GLN141 |
| A | FE213 |
| A | HOH338 |
| A | HOH345 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 215 |
| Chain | Residue |
| A | TYR54 |
| A | LEU175 |
| A | HOH567 |
| A | HOH573 |
Functional Information from PROSITE/UniProt
| site_id | PS00204 |
| Number of Residues | 21 |
| Details | FERRITIN_2 Ferritin iron-binding regions signature 2. DphLADFIEthYLneqvkaIK |
| Chain | Residue | Details |
| A | ASP126-LYS146 | |
| site_id | PS00540 |
| Number of Residues | 19 |
| Details | FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKLMklQNqRgGR |
| Chain | Residue | Details |
| A | GLU61-ARG79 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | GLU27 | |
| A | HIS65 | |
| Chain | Residue | Details |
| A | GLU62 | |
| A | GLU107 | |
| A | GLN141 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Essential for association with cargo receptor NCOA4 => ECO:0000269|PubMed:26436293 |
| Chain | Residue | Details |
| A | ARG22 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylthreonine; in Ferritin heavy chain, N-terminally processed => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | SER178 | |
| Chain | Residue | Details |
| A | SER182 | |
