6WX8

SOX2 bound to Importin-alpha 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006606	biological_process	protein import into nucleus
A	0061608	molecular_function	nuclear import signal receptor activity
B	0006355	biological_process	regulation of DNA-templated transcription
C	0005737	cellular_component	cytoplasm
C	0006606	biological_process	protein import into nucleus
C	0061608	molecular_function	nuclear import signal receptor activity
D	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 601

Chain	Residue
A	THR71
A	SER72
A	LEU73
A	GLU74

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 B 201

Chain	Residue
A	ARG229
B	ARG111
B	ARG113
B	ARG114

---

site_id	AC3
Number of Residues	2
Details	binding site for residue SO4 B 202

Chain	Residue
B	ARG98
A	LYS231

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 D 201

Chain	Residue
C	ARG229
D	ARG111
D	ARG113
D	ARG114
D	HOH308

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 D 202

Chain	Residue
C	ARG229
C	HIS230
C	LYS231
C	ASP232
D	ARG98

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Repeat: {"description":"ARM 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	88
Details	Repeat: {"description":"ARM 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	76
Details	Repeat: {"description":"ARM 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	88
Details	Repeat: {"description":"ARM 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	78
Details	Repeat: {"description":"ARM 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	82
Details	Repeat: {"description":"ARM 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	78
Details	Repeat: {"description":"ARM 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	84
Details	Repeat: {"description":"ARM 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	76
Details	Repeat: {"description":"ARM 10; atypical"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	184
Details	Region: {"description":"NLS binding site (major)","evidences":[{"source":"PubMed","id":"29042532","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	176
Details	Region: {"description":"NLS binding site (minor)","evidences":[{"source":"PubMed","id":"29042532","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	136
Details	DNA binding: {"description":"HMG box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00267","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"29358331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---