6WW3
Crystal structure of HERC2 ZZ domain in complex with SUMO1 tail
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 2801 |
| Chain | Residue |
| A | CYS2708 |
| A | CYS2711 |
| A | CYS2732 |
| A | CYS2735 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 2802 |
| Chain | Residue |
| A | CYS2723 |
| A | CYS2726 |
| A | HIS2741 |
| A | HIS2745 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 2803 |
| Chain | Residue |
| A | PRO2704 |
| A | HOH2907 |
| A | ILE2702 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 2801 |
| Chain | Residue |
| B | CYS2723 |
| B | CYS2726 |
| B | HIS2741 |
| B | HIS2745 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 2802 |
| Chain | Residue |
| B | CYS2708 |
| B | CYS2711 |
| B | CYS2732 |
| B | CYS2735 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 2803 |
| Chain | Residue |
| A | GLN2755 |
| B | ASP2727 |
| B | HOH2911 |
Functional Information from PROSITE/UniProt
| site_id | PS01357 |
| Number of Residues | 28 |
| Details | ZF_ZZ_1 Zinc finger ZZ-type signature. CdgCqmfpingsRFkCrn...CdDFdFCetC |
| Chain | Residue | Details |
| A | CYS2708-CYS2735 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 52 |
| Details | Zinc finger: {"description":"ZZ-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00228","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00228","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18707152","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
