6WW3

Crystal structure of HERC2 ZZ domain in complex with SUMO1 tail

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
B	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 2801

Chain	Residue
A	CYS2708
A	CYS2711
A	CYS2732
A	CYS2735

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 2802

Chain	Residue
A	CYS2723
A	CYS2726
A	HIS2741
A	HIS2745

---

site_id	AC3
Number of Residues	3
Details	binding site for residue PEG A 2803

Chain	Residue
A	PRO2704
A	HOH2907
A	ILE2702

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 2801

Chain	Residue
B	CYS2723
B	CYS2726
B	HIS2741
B	HIS2745

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 2802

Chain	Residue
B	CYS2708
B	CYS2711
B	CYS2732
B	CYS2735

---

site_id	AC6
Number of Residues	3
Details	binding site for residue GOL B 2803

Chain	Residue
A	GLN2755
B	ASP2727
B	HOH2911

---

Functional Information from PROSITE/UniProt

site_id	PS01357
Number of Residues	28
Details	ZF_ZZ_1 Zinc finger ZZ-type signature. CdgCqmfpingsRFkCrn...CdDFdFCetC

Chain	Residue	Details
A	CYS2708-CYS2735

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:18707152, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER1
B	SER1

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS6
B	LYS6

---

site_id	SWS_FT_FI3
Number of Residues	104
Details	ZN_FING: ZZ-type => ECO:0000255|PROSITE-ProRule:PRU00228

Chain	Residue	Details
A	HIS2703-GLN2755
B	HIS2703-GLN2755

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00228

Chain	Residue	Details
A	CYS2708
B	CYS2711
B	CYS2723
B	CYS2726
B	CYS2732
B	CYS2735
B	HIS2741
B	HIS2745
A	CYS2711
A	CYS2723
A	CYS2726
A	CYS2732
A	CYS2735
A	HIS2741
A	HIS2745
B	CYS2708

---