Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6WVV

Plasmodium vivax M17 leucyl aminopeptidase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0019538	biological_process	protein metabolic process
A	0030145	molecular_function	manganese ion binding
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0019538	biological_process	protein metabolic process
B	0030145	molecular_function	manganese ion binding
B	0046872	molecular_function	metal ion binding
B	0070006	molecular_function	metalloaminopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0019538	biological_process	protein metabolic process
C	0030145	molecular_function	manganese ion binding
C	0046872	molecular_function	metal ion binding
C	0070006	molecular_function	metalloaminopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0019538	biological_process	protein metabolic process
D	0030145	molecular_function	manganese ion binding
D	0046872	molecular_function	metal ion binding
D	0070006	molecular_function	metalloaminopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0019538	biological_process	protein metabolic process
E	0030145	molecular_function	manganese ion binding
E	0046872	molecular_function	metal ion binding
E	0070006	molecular_function	metalloaminopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0019538	biological_process	protein metabolic process
F	0030145	molecular_function	manganese ion binding
F	0046872	molecular_function	metal ion binding
F	0070006	molecular_function	metalloaminopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0019538	biological_process	protein metabolic process
G	0030145	molecular_function	manganese ion binding
G	0046872	molecular_function	metal ion binding
G	0070006	molecular_function	metalloaminopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0006508	biological_process	proteolysis
H	0019538	biological_process	protein metabolic process
H	0030145	molecular_function	manganese ion binding
H	0046872	molecular_function	metal ion binding
H	0070006	molecular_function	metalloaminopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0006508	biological_process	proteolysis
I	0019538	biological_process	protein metabolic process
I	0030145	molecular_function	manganese ion binding
I	0046872	molecular_function	metal ion binding
I	0070006	molecular_function	metalloaminopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0006508	biological_process	proteolysis
J	0019538	biological_process	protein metabolic process
J	0030145	molecular_function	manganese ion binding
J	0046872	molecular_function	metal ion binding
J	0070006	molecular_function	metalloaminopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0006508	biological_process	proteolysis
K	0019538	biological_process	protein metabolic process
K	0030145	molecular_function	manganese ion binding
K	0046872	molecular_function	metal ion binding
K	0070006	molecular_function	metalloaminopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0006508	biological_process	proteolysis
L	0019538	biological_process	protein metabolic process
L	0030145	molecular_function	manganese ion binding
L	0046872	molecular_function	metal ion binding
L	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from PROSITE/UniProt

site_id	PS00631
Number of Residues	8
Details	CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL

Chain	Residue	Details
A	ASN473-LEU480

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ACT_SITE: ACT_SITE => ECO:0000250\|UniProtKB:P00727

Chain	Residue	Details
A	ILE429
A	ALA506
B	ILE429
B	ALA506
C	ILE429
C	ALA506
D	ILE429
D	ALA506
E	ILE429
E	ALA506
F	ILE429
F	ALA506
G	ILE429
G	ALA506
H	ILE429
H	ALA506
I	ILE429
I	ALA506
J	ILE429
J	ALA506
K	ILE429
K	ALA506
L	ILE429
L	ALA506

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269\|PubMed:33303633, ECO:0000312\|PDB:7K5K, ECO:0007744\|PDB:6WVV

Chain	Residue	Details
A	SER417
A	VAL422
A	THR502
A	THR504
B	SER417
B	VAL422
B	THR502
B	THR504
C	SER417
C	VAL422
C	THR502
C	THR504
D	SER417
D	VAL422
D	THR502
D	THR504
E	SER417
E	VAL422
E	THR502
E	THR504
F	SER417
F	VAL422
F	THR502
F	THR504
G	SER417
G	VAL422
G	THR502
G	THR504
H	SER417
H	VAL422
H	THR502
H	THR504
I	SER417
I	VAL422
I	THR502
I	THR504
J	SER417
J	VAL422
J	THR502
J	THR504
K	SER417
K	VAL422
K	THR502
K	THR504
L	SER417
L	VAL422
L	THR502
L	THR504

site_id	SWS_FT_FI3
Number of Residues	48
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q8IL11

Chain	Residue	Details
A	ILE429
A	VAL437
A	VAL439
A	LEU442
B	ILE429
B	VAL437
B	VAL439
B	LEU442
C	ILE429
C	VAL437
C	VAL439
C	LEU442
D	ILE429
D	VAL437
D	VAL439
D	LEU442
E	ILE429
E	VAL437
E	VAL439
E	LEU442
F	ILE429
F	VAL437
F	VAL439
F	LEU442
G	ILE429
G	VAL437
G	VAL439
G	LEU442
H	ILE429
H	VAL437
H	VAL439
H	LEU442
I	ILE429
I	VAL437
I	VAL439
I	LEU442
J	ILE429
J	VAL437
J	VAL439
J	LEU442
K	ILE429
K	VAL437
K	VAL439
K	LEU442
L	ILE429
L	VAL437
L	VAL439
L	LEU442

site_id	SWS_FT_FI4
Number of Residues	12
Details	SITE: Essential for hexamer stabilization => ECO:0000250\|UniProtKB:Q8IL11

Chain	Residue	Details
A	LYS413
B	LYS413
C	LYS413
D	LYS413
E	LYS413
F	LYS413
G	LYS413
H	LYS413
I	LYS413
J	LYS413
K	LYS413
L	LYS413

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)