6WTH

Full-length human ENaC ECD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001669	cellular_component	acrosomal vesicle
A	0005272	molecular_function	sodium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0006883	biological_process	intracellular sodium ion homeostasis
A	0008217	biological_process	regulation of blood pressure
A	0009897	cellular_component	external side of plasma membrane
A	0015081	molecular_function	sodium ion transmembrane transporter activity
A	0015280	molecular_function	ligand-gated sodium channel activity
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031514	cellular_component	motile cilium
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034706	cellular_component	sodium channel complex
A	0035725	biological_process	sodium ion transmembrane transport
A	0050699	molecular_function	WW domain binding
A	0050891	biological_process	multicellular organismal-level water homeostasis
A	0050914	biological_process	sensory perception of salty taste
A	0050915	biological_process	sensory perception of sour taste
A	0055078	biological_process	sodium ion homeostasis
A	0060170	cellular_component	ciliary membrane
A	0070062	cellular_component	extracellular exosome
A	0071468	biological_process	cellular response to acidic pH
A	0097228	cellular_component	sperm principal piece
A	0098719	biological_process	sodium ion import across plasma membrane
A	1904045	biological_process	cellular response to aldosterone
A	1904117	biological_process	cellular response to vasopressin
B	0005272	molecular_function	sodium channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0006883	biological_process	intracellular sodium ion homeostasis
B	0008217	biological_process	regulation of blood pressure
B	0009897	cellular_component	external side of plasma membrane
B	0015081	molecular_function	sodium ion transmembrane transporter activity
B	0015280	molecular_function	ligand-gated sodium channel activity
B	0016020	cellular_component	membrane
B	0016324	cellular_component	apical plasma membrane
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034706	cellular_component	sodium channel complex
B	0035725	biological_process	sodium ion transmembrane transport
B	0050699	molecular_function	WW domain binding
B	0050891	biological_process	multicellular organismal-level water homeostasis
B	0050914	biological_process	sensory perception of salty taste
B	0050915	biological_process	sensory perception of sour taste
B	0055078	biological_process	sodium ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071468	biological_process	cellular response to acidic pH
B	0098719	biological_process	sodium ion import across plasma membrane
B	1904045	biological_process	cellular response to aldosterone
B	1904117	biological_process	cellular response to vasopressin
C	0005216	molecular_function	monoatomic ion channel activity
C	0005272	molecular_function	sodium channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0006883	biological_process	intracellular sodium ion homeostasis
C	0008217	biological_process	regulation of blood pressure
C	0009897	cellular_component	external side of plasma membrane
C	0015081	molecular_function	sodium ion transmembrane transporter activity
C	0015280	molecular_function	ligand-gated sodium channel activity
C	0016020	cellular_component	membrane
C	0016324	cellular_component	apical plasma membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034706	cellular_component	sodium channel complex
C	0035725	biological_process	sodium ion transmembrane transport
C	0050699	molecular_function	WW domain binding
C	0050891	biological_process	multicellular organismal-level water homeostasis
C	0050914	biological_process	sensory perception of salty taste
C	0050915	biological_process	sensory perception of sour taste
C	0055078	biological_process	sodium ion homeostasis
C	0070062	cellular_component	extracellular exosome
C	0071468	biological_process	cellular response to acidic pH
C	0098719	biological_process	sodium ion import across plasma membrane
C	1904045	biological_process	cellular response to aldosterone
C	1904117	biological_process	cellular response to vasopressin

Functional Information from PROSITE/UniProt

site_id	PS01206
Number of Residues	21
Details	ASC Amiloride-sensitive sodium channels signature. YsiQaClrsCfQdhMIrnCnC

Chain	Residue	Details
B	TYR381-CYS401
A	TYR411-CYS431
C	TYR389-CYS409

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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