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6WOH

Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 1,5-di-methylenebisphosphonate inositol tetrakisphosphate (1,5-PCP-IP4)

Functional Information from GO Data
ChainGOidnamespacecontents
A0016462molecular_functionpyrophosphatase activity
A0016787molecular_functionhydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue 4WZ A 401
ChainResidue
ASER39
AHOH514
AHOH532
AHOH540
AHOH546
AHOH576
ASER40
AARG41
AHIS42
AARG45
AARG89
AARG115
ALYS133
AHOH501

site_idAC2
Number of Residues10
Detailsbinding site for residue SO4 A 402
ChainResidue
AARG20
AASN86
AARG89
AHIS91
ALYS133
AGLN136
AHOH511
AHOH536
AHOH543
AHOH561

site_idAC3
Number of Residues8
Detailsbinding site for residue SO4 A 403
ChainResidue
ALYS18
AARG20
AGLY51
AGLY52
AHIS91
AHOH501
AHOH532
AHOH539

Functional Information from PROSITE/UniProt
site_idPS00893
Number of Residues22
DetailsNUDIX_BOX Nudix box signature. GgmepeEepsvAAvREVcEEaG
ChainResidueDetails
AGLY51-GLY72

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000305
ChainResidueDetails
AGLU69

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:19585659, ECO:0007744|PDB:2FVV, ECO:0007744|PDB:2Q9P
ChainResidueDetails
AARG10
ALYS18
ASER39
AARG89
ALYS133

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:19585659, ECO:0007744|PDB:2Q9P
ChainResidueDetails
AGLY50
AGLU66
AGLU70
AARG115

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
AMET1

226707

PDB entries from 2024-10-30

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