6WOH
Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 1,5-di-methylenebisphosphonate inositol tetrakisphosphate (1,5-PCP-IP4)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue 4WZ A 401 |
| Chain | Residue |
| A | SER39 |
| A | HOH514 |
| A | HOH532 |
| A | HOH540 |
| A | HOH546 |
| A | HOH576 |
| A | SER40 |
| A | ARG41 |
| A | HIS42 |
| A | ARG45 |
| A | ARG89 |
| A | ARG115 |
| A | LYS133 |
| A | HOH501 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ARG20 |
| A | ASN86 |
| A | ARG89 |
| A | HIS91 |
| A | LYS133 |
| A | GLN136 |
| A | HOH511 |
| A | HOH536 |
| A | HOH543 |
| A | HOH561 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | LYS18 |
| A | ARG20 |
| A | GLY51 |
| A | GLY52 |
| A | HIS91 |
| A | HOH501 |
| A | HOH532 |
| A | HOH539 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GgmepeEepsvAAvREVcEEaG |
| Chain | Residue | Details |
| A | GLY51-GLY72 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 125 |
| Details | Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Motif: {"description":"Nudix box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19585659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Q9P","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19585659","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Q9P","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
