6WM8
Proliferation-Associated protein 2G4 (PA2G4)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003714 | molecular_function | transcription corepressor activity |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006364 | biological_process | rRNA processing |
| A | 0006417 | biological_process | regulation of translation |
| A | 0016020 | cellular_component | membrane |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0045597 | biological_process | positive regulation of cell differentiation |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1990904 | cellular_component | ribonucleoprotein complex |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003714 | molecular_function | transcription corepressor activity |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006364 | biological_process | rRNA processing |
| B | 0006417 | biological_process | regulation of translation |
| B | 0016020 | cellular_component | membrane |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0045597 | biological_process | positive regulation of cell differentiation |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1990904 | cellular_component | ribonucleoprotein complex |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003714 | molecular_function | transcription corepressor activity |
| C | 0003723 | molecular_function | RNA binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005634 | cellular_component | nucleus |
| C | 0005730 | cellular_component | nucleolus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006364 | biological_process | rRNA processing |
| C | 0006417 | biological_process | regulation of translation |
| C | 0016020 | cellular_component | membrane |
| C | 0031625 | molecular_function | ubiquitin protein ligase binding |
| C | 0035578 | cellular_component | azurophil granule lumen |
| C | 0043066 | biological_process | negative regulation of apoptotic process |
| C | 0045597 | biological_process | positive regulation of cell differentiation |
| C | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 1990904 | cellular_component | ribonucleoprotein complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 501 |
| Chain | Residue |
| A | ARG33 |
| A | GLY336 |
| A | PRO337 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | HIS147 |
| A | ARG332 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | LYS191 |
| A | GLY197 |
| A | GLU198 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | HIS175 |
| A | ASN171 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | ARG332 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 506 |
| Chain | Residue |
| A | GLU14 |
| A | ASP15 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 507 |
| Chain | Residue |
| A | SER41 |
| A | LYS101 |
| A | GLU102 |
| B | LYS68 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 508 |
| Chain | Residue |
| A | GLN350 |
| A | ASP351 |
| A | ALA352 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 509 |
| Chain | Residue |
| A | LYS144 |
| A | HOH607 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | HIS147 |
| B | ARG332 |
| B | HOH525 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | LYS191 |
| B | GLY197 |
| B | GLU198 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | ARG33 |
| B | PRO337 |
| B | HOH528 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| B | LYS93 |
| B | ARG281 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 405 |
| Chain | Residue |
| B | ASN171 |
| B | HIS175 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 B 406 |
| Chain | Residue |
| B | ARG332 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 407 |
| Chain | Residue |
| B | GLU14 |
| B | ASP15 |
| B | HOH530 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 408 |
| Chain | Residue |
| B | SER41 |
| B | LYS101 |
| B | GLU102 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 409 |
| Chain | Residue |
| B | GLN134 |
| B | TYR343 |
| B | LYS344 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 401 |
| Chain | Residue |
| C | HIS147 |
| C | ARG332 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 402 |
| Chain | Residue |
| C | ARG33 |
| C | PRO337 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 403 |
| Chain | Residue |
| A | ASN328 |
| B | ASN328 |
| C | ASN328 |
| site_id | AE4 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 C 404 |
| Chain | Residue |
| C | ARG332 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 405 |
| Chain | Residue |
| C | THR206 |
| C | ASP207 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 406 |
| Chain | Residue |
| C | THR136 |
| C | GLY137 |
| C | ARG138 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 407 |
| Chain | Residue |
| C | GLU14 |
| C | ASP15 |
| site_id | AE8 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 408 |
| Chain | Residue |
| C | ARG272 |
| C | PHE273 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 409 |
| Chain | Residue |
| C | SER41 |
| C | LYS101 |
| C | GLU102 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 410 |
| Chain | Residue |
| C | LYS191 |
| C | GLY197 |
| C | GLU198 |
Functional Information from PROSITE/UniProt
| site_id | PS01202 |
| Number of Residues | 17 |
| Details | MAP_2 Methionine aminopeptidase subfamily 2 signature. DLvKIDlGvHVDGfiaN |
| Chain | Residue | Details |
| A | ASP104-ASN120 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 | |
| C | SER2 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER335 | |
| B | SER335 | |
| C | SER335 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine; by PKC/PRKCD => ECO:0000269|PubMed:16832058, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER361 | |
| B | SER361 | |
| C | SER361 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS298 | |
| B | LYS298 | |
| C | LYS298 |
