Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6WM8

Proliferation-Associated protein 2G4 (PA2G4)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003714	molecular_function	transcription corepressor activity
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006351	biological_process	DNA-templated transcription
A	0006364	biological_process	rRNA processing
A	0006417	biological_process	regulation of translation
A	0016020	cellular_component	membrane
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0035578	cellular_component	azurophil granule lumen
A	0043066	biological_process	negative regulation of apoptotic process
A	0045597	biological_process	positive regulation of cell differentiation
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0070062	cellular_component	extracellular exosome
A	1990904	cellular_component	ribonucleoprotein complex
B	0003676	molecular_function	nucleic acid binding
B	0003714	molecular_function	transcription corepressor activity
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006351	biological_process	DNA-templated transcription
B	0006364	biological_process	rRNA processing
B	0006417	biological_process	regulation of translation
B	0016020	cellular_component	membrane
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0035578	cellular_component	azurophil granule lumen
B	0043066	biological_process	negative regulation of apoptotic process
B	0045597	biological_process	positive regulation of cell differentiation
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0070062	cellular_component	extracellular exosome
B	1990904	cellular_component	ribonucleoprotein complex
C	0003676	molecular_function	nucleic acid binding
C	0003714	molecular_function	transcription corepressor activity
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006364	biological_process	rRNA processing
C	0006417	biological_process	regulation of translation
C	0016020	cellular_component	membrane
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0035578	cellular_component	azurophil granule lumen
C	0043066	biological_process	negative regulation of apoptotic process
C	0045597	biological_process	positive regulation of cell differentiation
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0070062	cellular_component	extracellular exosome
C	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 501

Chain	Residue
A	ARG33
A	GLY336
A	PRO337

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 502

Chain	Residue
A	HIS147
A	ARG332

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 503

Chain	Residue
A	LYS191
A	GLY197
A	GLU198

site_id	AC4
Number of Residues	2
Details	binding site for residue SO4 A 504

Chain	Residue
A	HIS175
A	ASN171

site_id	AC5
Number of Residues	1
Details	binding site for residue SO4 A 505

Chain	Residue
A	ARG332

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 A 506

Chain	Residue
A	GLU14
A	ASP15

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 A 507

Chain	Residue
A	SER41
A	LYS101
A	GLU102
B	LYS68

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 A 508

Chain	Residue
A	GLN350
A	ASP351
A	ALA352

site_id	AC9
Number of Residues	2
Details	binding site for residue SO4 A 509

Chain	Residue
A	LYS144
A	HOH607

site_id	AD1
Number of Residues	3
Details	binding site for residue SO4 B 401

Chain	Residue
B	HIS147
B	ARG332
B	HOH525

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 B 402

Chain	Residue
B	LYS191
B	GLY197
B	GLU198

site_id	AD3
Number of Residues	3
Details	binding site for residue SO4 B 403

Chain	Residue
B	ARG33
B	PRO337
B	HOH528

site_id	AD4
Number of Residues	2
Details	binding site for residue SO4 B 404

Chain	Residue
B	LYS93
B	ARG281

site_id	AD5
Number of Residues	2
Details	binding site for residue SO4 B 405

Chain	Residue
B	ASN171
B	HIS175

site_id	AD6
Number of Residues	1
Details	binding site for residue SO4 B 406

Chain	Residue
B	ARG332

site_id	AD7
Number of Residues	3
Details	binding site for residue SO4 B 407

Chain	Residue
B	GLU14
B	ASP15
B	HOH530

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 B 408

Chain	Residue
B	SER41
B	LYS101
B	GLU102

site_id	AD9
Number of Residues	3
Details	binding site for residue SO4 B 409

Chain	Residue
B	GLN134
B	TYR343
B	LYS344

site_id	AE1
Number of Residues	2
Details	binding site for residue SO4 C 401

Chain	Residue
C	HIS147
C	ARG332

site_id	AE2
Number of Residues	2
Details	binding site for residue SO4 C 402

Chain	Residue
C	ARG33
C	PRO337

site_id	AE3
Number of Residues	3
Details	binding site for residue SO4 C 403

Chain	Residue
A	ASN328
B	ASN328
C	ASN328

site_id	AE4
Number of Residues	1
Details	binding site for residue SO4 C 404

Chain	Residue
C	ARG332

site_id	AE5
Number of Residues	2
Details	binding site for residue SO4 C 405

Chain	Residue
C	THR206
C	ASP207

site_id	AE6
Number of Residues	3
Details	binding site for residue SO4 C 406

Chain	Residue
C	THR136
C	GLY137
C	ARG138

site_id	AE7
Number of Residues	2
Details	binding site for residue SO4 C 407

Chain	Residue
C	GLU14
C	ASP15

site_id	AE8
Number of Residues	2
Details	binding site for residue SO4 C 408

Chain	Residue
C	ARG272
C	PHE273

site_id	AE9
Number of Residues	3
Details	binding site for residue SO4 C 409

Chain	Residue
C	SER41
C	LYS101
C	GLU102

site_id	AF1
Number of Residues	3
Details	binding site for residue SO4 C 410

Chain	Residue
C	LYS191
C	GLY197
C	GLU198

Functional Information from PROSITE/UniProt

site_id	PS01202
Number of Residues	17
Details	MAP_2 Methionine aminopeptidase subfamily 2 signature. DLvKIDlGvHVDGfiaN

Chain	Residue	Details
A	ASP104-ASN120

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Region: {"description":"RNA-binding","evidences":[{"source":"PubMed","id":"15064750","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)