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6WLC

Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-5'-Monophosphate

Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue U5P A 401
ChainResidue
AHIS250
AHOH655
ALYS290
AVAL292
ACYS293
ASER294
ATYR343
ALEU346
AHOH540
AHOH646

site_idAC2
Number of Residues5
Detailsbinding site for residue TRS A 402
ChainResidue
APHE44
AGLU45
AASP92
AHOH509
AHOH661

site_idAC3
Number of Residues9
Detailsbinding site for residue EDO A 403
ChainResidue
AASN0
AASN53
AGLU57
ACYS103
ASER104
AMET105
BGLU4
BPRO24
BVAL25

site_idAC4
Number of Residues2
Detailsbinding site for residue ACT A 404
ChainResidue
AGLU340
AHOH646

site_idAC5
Number of Residues3
Detailsbinding site for residue EDO A 405
ChainResidue
AASN200
ALEU201
ATYR279

site_idAC6
Number of Residues5
Detailsbinding site for residue EDO A 406
ChainResidue
AASN74
AVAL78
AASP79
AHOH511
AHOH533

site_idAC7
Number of Residues6
Detailsbinding site for residue EDO A 407
ChainResidue
ALEU312
ASER313
AVAL314
ALYS335
AASP336
AGLY337

site_idAC8
Number of Residues5
Detailsbinding site for residue EDO A 408
ChainResidue
AGLU69
AVAL70
ATYR89
ALYS90
AASP273

site_idAC9
Number of Residues4
Detailsbinding site for residue EDO A 409
ChainResidue
AASN75
ALEU76
ALYS181
ATYR325

site_idAD1
Number of Residues7
Detailsbinding site for residue SO4 A 410
ChainResidue
AGLU229
AGLY230
ATYR231
AGLY337
AHIS338
AHOH513
AHOH688

site_idAD2
Number of Residues9
Detailsbinding site for residue U5P B 401
ChainResidue
BHIS250
BLYS290
BVAL292
BCYS293
BSER294
BTYR343
BLEU346
BHOH592
BHOH660

site_idAD3
Number of Residues7
Detailsbinding site for residue TRS B 402
ChainResidue
BPHE44
BGLU45
BTRP59
BASP92
BFMT410
BEDO411
BHOH543

site_idAD4
Number of Residues8
Detailsbinding site for residue EDO B 403
ChainResidue
ALYS320
AVAL321
ATHR322
AGLU327
BVAL149
BLYS150
BGLY151
BHOH692

site_idAD5
Number of Residues4
Detailsbinding site for residue EDO B 404
ChainResidue
BSER155
BVAL156
BGLU192
BTHR193

site_idAD6
Number of Residues7
Detailsbinding site for residue ACT B 405
ChainResidue
BLEU312
BSER313
BVAL314
BVAL315
BLYS335
BASP336
BGLY337

site_idAD7
Number of Residues5
Detailsbinding site for residue EDO B 406
ChainResidue
BGLU192
BLYS320
BTHR322
BGLU327
BHOH681

site_idAD8
Number of Residues4
Detailsbinding site for residue ACT B 407
ChainResidue
BASN178
BGLU146
BLYS174
BGLN176

site_idAD9
Number of Residues7
Detailsbinding site for residue ACT B 408
ChainResidue
AGLU192
BGLY126
BTHR145
BGLY147
BSER148
BVAL149
BHOH571

site_idAE1
Number of Residues2
Detailsbinding site for residue FMT B 409
ChainResidue
BGLU42
BHOH643

site_idAE2
Number of Residues5
Detailsbinding site for residue FMT B 410
ChainResidue
BASP92
BTRS402
BEDO411
BHOH513
BHOH537

site_idAE3
Number of Residues3
Detailsbinding site for residue EDO B 411
ChainResidue
BGLU45
BTRS402
BFMT410

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093
ChainResidueDetails
AHIS235
BHIS235

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Proton acceptor; for uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093
ChainResidueDetails
AHIS250
BHIS250

site_idSWS_FT_FI3
Number of Residues2
DetailsACT_SITE: For uridylate-specific endoribonuclease nsp15 activity => ECO:0000269|PubMed:33504779
ChainResidueDetails
ALYS290
BLYS290

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093
ChainResidueDetails
ALYS290
BLYS290

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:33564093
ChainResidueDetails
ATHR341
BTHR341

site_idSWS_FT_FI6
Number of Residues2
DetailsSITE: Transition state stabilizer => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093
ChainResidueDetails
ALYS290
BLYS290

site_idSWS_FT_FI7
Number of Residues2
DetailsSITE: Uracil recognition site => ECO:0000269|PubMed:33504779, ECO:0000269|PubMed:33564093
ChainResidueDetails
ASER294
BSER294

site_idSWS_FT_FI8
Number of Residues2
DetailsSITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3
ChainResidueDetails
AGLN347
BGLN347

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PDB entries from 2024-10-30

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