6WKW
EM structure of CtBP2 with a minimal dehydrogenase domain of CtBP2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003714 | molecular_function | transcription corepressor activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0051287 | molecular_function | NAD binding |
| B | 0003714 | molecular_function | transcription corepressor activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0051287 | molecular_function | NAD binding |
| C | 0003714 | molecular_function | transcription corepressor activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0051287 | molecular_function | NAD binding |
| D | 0003714 | molecular_function | transcription corepressor activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue NAD D 401 |
| Chain | Residue |
| D | SER106 |
| D | HIS242 |
| D | CYS243 |
| D | ASN244 |
| D | ASN249 |
| D | ALA271 |
| D | ARG272 |
| D | ASP296 |
| D | HIS321 |
| D | ALA323 |
| D | THR134 |
| D | GLY189 |
| D | ARG190 |
| D | THR191 |
| D | TYR209 |
| D | ASP210 |
| D | PRO211 |
| D | TYR212 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue NAD C 401 |
| Chain | Residue |
| C | THR134 |
| C | ILE186 |
| C | GLY189 |
| C | ARG190 |
| C | THR191 |
| C | ASP210 |
| C | TYR212 |
| C | HIS242 |
| C | CYS243 |
| C | ASN244 |
| C | ASN249 |
| C | ALA270 |
| C | ALA271 |
| C | ARG272 |
| C | ASP296 |
| C | HIS321 |
| C | ALA323 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| B | SER106 |
| B | GLY107 |
| B | THR134 |
| B | ILE186 |
| B | GLY187 |
| B | GLY189 |
| B | ARG190 |
| B | THR191 |
| B | TYR209 |
| B | ASP210 |
| B | PRO211 |
| B | TYR212 |
| B | HIS242 |
| B | CYS243 |
| B | ASN244 |
| B | ASN249 |
| B | ARG272 |
| B | ASP296 |
| B | HIS321 |
| B | ALA323 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | SER106 |
| A | GLY107 |
| A | THR134 |
| A | GLY189 |
| A | ARG190 |
| A | THR191 |
| A | TYR209 |
| A | ASP210 |
| A | PRO211 |
| A | TYR212 |
| A | HIS242 |
| A | CYS243 |
| A | ASN244 |
| A | ASN249 |
| A | ARG272 |
| A | ASP296 |
| A | HIS321 |
| A | ALA323 |
| A | TRP324 |
Functional Information from PROSITE/UniProt
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MRqGaFLVNaARGgLVD |
| Chain | Residue | Details |
| D | MET261-ASP277 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 72 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human CTBP2 dehydrogenase complexed with NAD(H).","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
