6WK1
SETD3 in Complex with an Actin Peptide with His73 Replaced with Methionine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000785 | cellular_component | chromatin |
| A | 0003713 | molecular_function | transcription coactivator activity |
| A | 0003779 | molecular_function | actin binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018021 | biological_process | peptidyl-histidine methylation |
| A | 0018023 | biological_process | peptidyl-lysine trimethylation |
| A | 0018064 | molecular_function | protein-L-histidine N-tele-methyltransferase activity |
| A | 0030047 | biological_process | actin modification |
| A | 0032259 | biological_process | methylation |
| A | 0042800 | molecular_function | histone H3K4 methyltransferase activity |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0046975 | molecular_function | histone H3K36 methyltransferase activity |
| A | 0061629 | molecular_function | RNA polymerase II-specific DNA-binding transcription factor binding |
| A | 0070472 | biological_process | regulation of uterine smooth muscle contraction |
| B | 0000785 | cellular_component | chromatin |
| B | 0003713 | molecular_function | transcription coactivator activity |
| B | 0003779 | molecular_function | actin binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0018021 | biological_process | peptidyl-histidine methylation |
| B | 0018023 | biological_process | peptidyl-lysine trimethylation |
| B | 0018064 | molecular_function | protein-L-histidine N-tele-methyltransferase activity |
| B | 0030047 | biological_process | actin modification |
| B | 0032259 | biological_process | methylation |
| B | 0042800 | molecular_function | histone H3K4 methyltransferase activity |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 0046975 | molecular_function | histone H3K36 methyltransferase activity |
| B | 0061629 | molecular_function | RNA polymerase II-specific DNA-binding transcription factor binding |
| B | 0070472 | biological_process | regulation of uterine smooth muscle contraction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL Y 101 |
| Chain | Residue |
| A | ASN153 |
| A | EDO629 |
| Y | THR77 |
| Y | ASN78 |
| Y | LYS84 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO Y 102 |
| Chain | Residue |
| Y | TYR69 |
| Y | PRO70 |
| Y | ILE71 |
| A | GLN256 |
| A | ILE257 |
| A | PRO258 |
| A | VAL265 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue SAH A 601 |
| Chain | Residue |
| A | ARG74 |
| A | GLU102 |
| A | GLU103 |
| A | PHE105 |
| A | PRO179 |
| A | THR252 |
| A | ARG253 |
| A | ASP274 |
| A | MET275 |
| A | CYS276 |
| A | ASN277 |
| A | HIS278 |
| A | TYR312 |
| A | SER324 |
| A | PHE326 |
| A | HOH745 |
| A | HOH808 |
| A | HOH867 |
| A | HOH894 |
| A | HOH897 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 602 |
| Chain | Residue |
| A | LYS125 |
| A | PHE170 |
| A | TRP171 |
| A | HOH716 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | ILE338 |
| A | LYS339 |
| A | ARG432 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | TYR287 |
| A | ASN288 |
| A | LEU289 |
| A | GLU290 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 605 |
| Chain | Residue |
| A | LYS448 |
| A | EDO615 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 606 |
| Chain | Residue |
| A | SER316 |
| A | ASN317 |
| A | ALA318 |
| A | ASP334 |
| A | ARG335 |
| A | VAL336 |
| A | LEU466 |
| A | GLU470 |
| A | EDO608 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 607 |
| Chain | Residue |
| A | ASP204 |
| A | ALA318 |
| A | HIS323 |
| A | HOH757 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 608 |
| Chain | Residue |
| A | GLN200 |
| A | ALA201 |
| A | ALA318 |
| A | LYS337 |
| A | GLU470 |
| A | EDO606 |
| A | EDO612 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 609 |
| Chain | Residue |
| A | ALA382 |
| A | ILE407 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 610 |
| Chain | Residue |
| A | GLY72 |
| A | ASP76 |
| B | ARG60 |
| B | LYS61 |
| B | GLN63 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 611 |
| Chain | Residue |
| A | ILE113 |
| A | ASP301 |
| A | ARG303 |
| B | LYS114 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 612 |
| Chain | Residue |
| A | SER316 |
| A | GLU319 |
| A | ARG335 |
| A | VAL336 |
| A | LYS337 |
| A | EDO608 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 613 |
| Chain | Residue |
| A | LEU451 |
| A | HIS454 |
| A | ASP455 |
| A | LEU456 |
| A | LYS461 |
| A | HOH791 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 614 |
| Chain | Residue |
| A | ASP334 |
| A | GLY469 |
| A | GLU472 |
| A | ILE473 |
| A | HOH779 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 615 |
| Chain | Residue |
| A | LYS448 |
| A | GLU472 |
| A | EDO605 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 616 |
| Chain | Residue |
| A | GLU48 |
| A | SER207 |
| A | LYS210 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 617 |
| Chain | Residue |
| A | ARG60 |
| A | LYS61 |
| A | GLN63 |
| B | GLY72 |
| B | ASP76 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 618 |
| Chain | Residue |
| A | ILE24 |
| A | GLN63 |
| A | TYR220 |
| A | SER237 |
| A | PHE238 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 619 |
| Chain | Residue |
| A | PHE327 |
| A | VAL458 |
| A | LYS461 |
| A | MET462 |
| A | LYS465 |
| A | EDO623 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 620 |
| Chain | Residue |
| A | LEU399 |
| A | GLY400 |
| A | ASP401 |
| A | SER402 |
| A | ALA403 |
| A | ARG406 |
| A | HOH744 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 621 |
| Chain | Residue |
| A | TYR220 |
| A | GLN224 |
| A | LEU234 |
| A | LYS235 |
| A | HOH803 |
| A | HOH868 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 622 |
| Chain | Residue |
| A | LEU340 |
| A | GLY341 |
| A | PHE387 |
| A | ARG432 |
| A | HOH794 |
| site_id | AE7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 623 |
| Chain | Residue |
| A | ASP183 |
| A | GLY325 |
| A | PHE326 |
| A | PHE327 |
| A | VAL458 |
| A | MET462 |
| A | EDO619 |
| A | HOH745 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue ACT A 624 |
| Chain | Residue |
| A | PHE367 |
| A | ALA368 |
| A | SER377 |
| A | GLN379 |
| A | HOH704 |
| A | HOH709 |
| A | HOH861 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 625 |
| Chain | Residue |
| A | LEU66 |
| A | SER180 |
| A | GLU181 |
| B | LYS73 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 627 |
| Chain | Residue |
| A | ARG335 |
| A | VAL366 |
| A | HOH944 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 628 |
| Chain | Residue |
| A | PHE428 |
| A | ARG432 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 629 |
| Chain | Residue |
| A | GLN256 |
| A | VAL265 |
| A | HOH820 |
| Y | GOL101 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 630 |
| Chain | Residue |
| A | GLU96 |
| A | MET97 |
| A | HOH863 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 631 |
| Chain | Residue |
| A | GLN256 |
| Y | PRO70 |
| Y | ILE71 |
| Y | GLU72 |
| Y | HOH204 |
| site_id | AF6 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 632 |
| Chain | Residue |
| A | SER364 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 633 |
| Chain | Residue |
| A | LYS114 |
| B | ASP112 |
| B | LYS114 |
| site_id | AF8 |
| Number of Residues | 21 |
| Details | binding site for residue SAH B 1001 |
| Chain | Residue |
| B | ARG74 |
| B | GLU102 |
| B | GLU103 |
| B | PHE105 |
| B | PRO179 |
| B | THR252 |
| B | ARG253 |
| B | ASP274 |
| B | MET275 |
| B | CYS276 |
| B | ASN277 |
| B | HIS278 |
| B | TYR312 |
| B | SER324 |
| B | PHE326 |
| B | EDO1014 |
| B | HOH1174 |
| B | HOH1213 |
| B | HOH1251 |
| B | HOH1262 |
| B | HOH1295 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1002 |
| Chain | Residue |
| B | GLY313 |
| B | THR314 |
| B | HOH1228 |
| Z | GLU72 |
| site_id | AG1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1003 |
| Chain | Residue |
| B | ALA359 |
| B | ILE407 |
| site_id | AG2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1004 |
| Chain | Residue |
| B | GLU181 |
| B | ASP183 |
| B | EDO1010 |
| B | HOH1102 |
| B | HOH1103 |
| B | HOH1193 |
| site_id | AG3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1005 |
| Chain | Residue |
| A | LYS101 |
| B | GLU102 |
| B | EDO1014 |
| B | EDO1015 |
| B | HOH1103 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1006 |
| Chain | Residue |
| B | LEU340 |
| B | GLY341 |
| B | PHE387 |
| B | ARG432 |
| site_id | AG5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1007 |
| Chain | Residue |
| A | SER86 |
| B | MET82 |
| B | LYS83 |
| B | SER86 |
| B | HOH1127 |
| B | HOH1227 |
| site_id | AG6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 1008 |
| Chain | Residue |
| B | ASN317 |
| B | ALA318 |
| B | ASP334 |
| B | ARG335 |
| B | LEU466 |
| B | GLY469 |
| B | GLU470 |
| site_id | AG7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1009 |
| Chain | Residue |
| B | HIS333 |
| B | ARG335 |
| B | HIS370 |
| site_id | AG8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1010 |
| Chain | Residue |
| B | PRO179 |
| B | SER180 |
| B | GLU181 |
| B | EDO1004 |
| B | HOH1248 |
| B | HOH1273 |
| site_id | AG9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1011 |
| Chain | Residue |
| B | GLN63 |
| B | TYR220 |
| B | SER237 |
| B | PHE238 |
| site_id | AH1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1012 |
| Chain | Residue |
| B | ARG385 |
| B | HIS397 |
| B | ARG406 |
| B | THR409 |
| B | PHE415 |
| B | VAL417 |
| site_id | AH2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1013 |
| Chain | Residue |
| B | TRP121 |
| B | ARG293 |
| site_id | AH3 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 1014 |
| Chain | Residue |
| B | GLU103 |
| B | ASP183 |
| B | GLY325 |
| B | PHE326 |
| B | SAH1001 |
| B | EDO1005 |
| B | EDO1015 |
| B | HOH1102 |
| site_id | AH4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 1015 |
| Chain | Residue |
| B | PHE326 |
| B | PHE327 |
| B | VAL458 |
| B | MET462 |
| B | EDO1005 |
| B | EDO1014 |
| B | HOH1107 |
| site_id | AH5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1016 |
| Chain | Residue |
| B | ARG53 |
| B | GLU57 |
| B | ARG60 |
| B | ARG244 |
| site_id | AH6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1017 |
| Chain | Residue |
| B | GLU295 |
| Z | LEU67 |
| site_id | AH7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1018 |
| Chain | Residue |
| B | LEU399 |
| B | GLY400 |
| B | ASP401 |
| B | SER402 |
| B | ALA403 |
| B | ARG406 |
| site_id | AH8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1019 |
| Chain | Residue |
| A | LYS101 |
| A | GLU102 |
| B | LYS101 |
| site_id | AH9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1020 |
| Chain | Residue |
| B | ASP204 |
| B | ALA318 |
| B | LYS337 |
| B | HOH1155 |
| B | HOH1179 |
| B | HOH1232 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Lilla S.","von Kriegsheim A.","Lempens A.","Kolch W.","Dozynkiewicz M.","Norman J.C."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"23673617","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 440 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31911441","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31993215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2011","submissionDatabase":"PDB data bank","title":"Crystal structure of human SET domain-containing protein 3.","authors":["Zeng H.","Dong A.","Walker J.R.","Loppnau P.","Bountra C.","Weigelt J.","Arrowsmith C.H.","Edwards A.M.","Min J.","Wu H."]}},{"source":"PDB","id":"3SMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ICT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ICV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JAT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WK1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WK2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
