6WHW
GluN1b-GluN2B NMDA receptor in complex with GluN2B antagonist SDZ 220-040, class 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0038023 | molecular_function | signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0038023 | molecular_function | signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0038023 | molecular_function | signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0038023 | molecular_function | signaling receptor activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1400 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:24876489 |
| Chain | Residue | Details |
| B | ARG27-CYS557 | |
| B | THR647-ASN817 | |
| D | ARG27-CYS557 | |
| D | THR647-ASN817 | |
| C | ILE652-TYR668 | |
| C | MET834-ILE854 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 104 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:24876489 |
| Chain | Residue | Details |
| B | VAL558-VAL576 | |
| B | MET631-TYR646 | |
| B | MET818-ILE837 | |
| D | VAL558-VAL576 | |
| D | MET631-TYR646 | |
| D | MET818-ILE837 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 64 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:24876489 |
| Chain | Residue | Details |
| B | PHE577-GLY603 | |
| B | LYS624-ILE630 | |
| D | PHE577-GLY603 | |
| D | LYS624-ILE630 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | INTRAMEM: Discontinuously helical => ECO:0000305|PubMed:24876489 |
| Chain | Residue | Details |
| B | LYS604-PRO623 | |
| D | LYS604-PRO623 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:19910922, ECO:0007744|PDB:3JPY |
| Chain | Residue | Details |
| B | HIS127 | |
| B | GLU284 | |
| D | HIS127 | |
| D | GLU284 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5 |
| Chain | Residue | Details |
| B | THR514 | |
| B | ARG519 | |
| B | ASP732 | |
| D | THR514 | |
| D | ARG519 | |
| D | ASP732 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:4PE5 |
| Chain | Residue | Details |
| B | SER690 | |
| D | SER690 | |
| C | SER910 | |
| C | SER917 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | SITE: Functional determinant of NMDA receptors => ECO:0000250 |
| Chain | Residue | Details |
| B | ASN615 | |
| D | ASN615 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19910922, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:3JPW, ECO:0007744|PDB:3JPY, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM, ECO:0007744|PDB:4PE5 |
| Chain | Residue | Details |
| B | ASN74 | |
| D | ASN74 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19910922, ECO:0000269|PubMed:24876489, ECO:0007744|PDB:3JPW, ECO:0007744|PDB:3JPY, ECO:0007744|PDB:3QEL, ECO:0007744|PDB:3QEM, ECO:0007744|PDB:4PE5, ECO:0007744|PDB:5TPZ |
| Chain | Residue | Details |
| B | ASN341 | |
| D | ASN341 | |
| C | GLN61 | |
| C | ASP260 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASP348 | |
| B | ASN444 | |
| B | ASN491 | |
| B | ASN542 | |
| D | ASP348 | |
| D | ASN444 | |
| D | ASN491 | |
| D | ASN542 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5 |
| Chain | Residue | Details |
| B | ASN688 | |
| D | ASN688 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5 |
| Chain | Residue | Details |
| A | ASN321 | |
| C | ASN321 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0007744|PubMed:24090084 |
| Chain | Residue | Details |
| A | GLN371 | |
| A | GLN792 | |
| C | GLN371 | |
| C | GLN792 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24876489, ECO:0007744|PDB:4PE5, ECO:0007744|PubMed:24090084 |
| Chain | Residue | Details |
| A | ASN461 | |
| C | ASN461 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN492 | |
| A | GLN512 | |
| A | ASN695 | |
| C | GLN492 | |
| C | GLN512 | |
| C | ASN695 |
