6WFJ

Crystal structures of human E-NPP 1: apo

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AcA	0003676	molecular_function	nucleic acid binding
AcA	0004115	molecular_function	3',5'-cyclic-AMP phosphodiesterase activity
AcA	0004527	molecular_function	exonuclease activity
AcA	0004528	molecular_function	phosphodiesterase I activity
AcA	0004551	molecular_function	dinucleotide phosphatase activity
AcA	0005044	molecular_function	scavenger receptor activity
AcA	0005158	molecular_function	insulin receptor binding
AcA	0005509	molecular_function	calcium ion binding
AcA	0005515	molecular_function	protein binding
AcA	0005524	molecular_function	ATP binding
AcA	0005576	cellular_component	extracellular region
AcA	0005615	cellular_component	extracellular space
AcA	0005765	cellular_component	lysosomal membrane
AcA	0005886	cellular_component	plasma membrane
AcA	0006091	biological_process	generation of precursor metabolites and energy
AcA	0006796	biological_process	phosphate-containing compound metabolic process
AcA	0006955	biological_process	immune response
AcA	0008270	molecular_function	zinc ion binding
AcA	0009143	biological_process	nucleoside triphosphate catabolic process
AcA	0009986	cellular_component	cell surface
AcA	0010035	biological_process	obsolete response to inorganic substance
AcA	0010467	biological_process	gene expression
AcA	0016020	cellular_component	membrane
AcA	0016192	biological_process	vesicle-mediated transport
AcA	0016323	cellular_component	basolateral plasma membrane
AcA	0016787	molecular_function	hydrolase activity
AcA	0016788	molecular_function	hydrolase activity, acting on ester bonds
AcA	0016791	molecular_function	phosphatase activity
AcA	0030247	molecular_function	polysaccharide binding
AcA	0030282	biological_process	bone mineralization
AcA	0030308	biological_process	negative regulation of cell growth
AcA	0030318	biological_process	melanocyte differentiation
AcA	0030500	biological_process	regulation of bone mineralization
AcA	0030502	biological_process	negative regulation of bone mineralization
AcA	0030505	biological_process	inorganic diphosphate transport
AcA	0030643	biological_process	intracellular phosphate ion homeostasis
AcA	0030730	biological_process	sequestering of triglyceride
AcA	0031214	biological_process	biomineral tissue development
AcA	0031953	biological_process	negative regulation of protein autophosphorylation
AcA	0032869	biological_process	cellular response to insulin stimulus
AcA	0033198	biological_process	response to ATP
AcA	0036219	molecular_function	GTP diphosphatase activity
AcA	0036221	molecular_function	UTP diphosphatase activity
AcA	0042803	molecular_function	protein homodimerization activity
AcA	0045599	biological_process	negative regulation of fat cell differentiation
AcA	0045719	biological_process	negative regulation of glycogen biosynthetic process
AcA	0046034	biological_process	ATP metabolic process
AcA	0046325	biological_process	negative regulation of glucose import
AcA	0046627	biological_process	negative regulation of insulin receptor signaling pathway
AcA	0046872	molecular_function	metal ion binding
AcA	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
AcA	0047693	molecular_function	ATP diphosphatase activity
AcA	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
AcA	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
AcA	0055062	biological_process	phosphate ion homeostasis
AcA	0090304	biological_process	nucleic acid metabolic process
AcA	0106177	molecular_function	cyclic-GMP-AMP hydrolase activity
AcA	0110148	biological_process	obsolete biomineralization
AcA	1990787	biological_process	negative regulation of hh target transcription factor activity
BcB	0003676	molecular_function	nucleic acid binding
BcB	0004115	molecular_function	3',5'-cyclic-AMP phosphodiesterase activity
BcB	0004527	molecular_function	exonuclease activity
BcB	0004528	molecular_function	phosphodiesterase I activity
BcB	0004551	molecular_function	dinucleotide phosphatase activity
BcB	0005044	molecular_function	scavenger receptor activity
BcB	0005158	molecular_function	insulin receptor binding
BcB	0005509	molecular_function	calcium ion binding
BcB	0005515	molecular_function	protein binding
BcB	0005524	molecular_function	ATP binding
BcB	0005576	cellular_component	extracellular region
BcB	0005615	cellular_component	extracellular space
BcB	0005765	cellular_component	lysosomal membrane
BcB	0005886	cellular_component	plasma membrane
BcB	0006091	biological_process	generation of precursor metabolites and energy
BcB	0006796	biological_process	phosphate-containing compound metabolic process
BcB	0006955	biological_process	immune response
BcB	0008270	molecular_function	zinc ion binding
BcB	0009143	biological_process	nucleoside triphosphate catabolic process
BcB	0009986	cellular_component	cell surface
BcB	0010035	biological_process	obsolete response to inorganic substance
BcB	0010467	biological_process	gene expression
BcB	0016020	cellular_component	membrane
BcB	0016192	biological_process	vesicle-mediated transport
BcB	0016323	cellular_component	basolateral plasma membrane
BcB	0016787	molecular_function	hydrolase activity
BcB	0016788	molecular_function	hydrolase activity, acting on ester bonds
BcB	0016791	molecular_function	phosphatase activity
BcB	0030247	molecular_function	polysaccharide binding
BcB	0030282	biological_process	bone mineralization
BcB	0030308	biological_process	negative regulation of cell growth
BcB	0030318	biological_process	melanocyte differentiation
BcB	0030500	biological_process	regulation of bone mineralization
BcB	0030502	biological_process	negative regulation of bone mineralization
BcB	0030505	biological_process	inorganic diphosphate transport
BcB	0030643	biological_process	intracellular phosphate ion homeostasis
BcB	0030730	biological_process	sequestering of triglyceride
BcB	0031214	biological_process	biomineral tissue development
BcB	0031953	biological_process	negative regulation of protein autophosphorylation
BcB	0032869	biological_process	cellular response to insulin stimulus
BcB	0033198	biological_process	response to ATP
BcB	0036219	molecular_function	GTP diphosphatase activity
BcB	0036221	molecular_function	UTP diphosphatase activity
BcB	0042803	molecular_function	protein homodimerization activity
BcB	0045599	biological_process	negative regulation of fat cell differentiation
BcB	0045719	biological_process	negative regulation of glycogen biosynthetic process
BcB	0046034	biological_process	ATP metabolic process
BcB	0046325	biological_process	negative regulation of glucose import
BcB	0046627	biological_process	negative regulation of insulin receptor signaling pathway
BcB	0046872	molecular_function	metal ion binding
BcB	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
BcB	0047693	molecular_function	ATP diphosphatase activity
BcB	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
BcB	0050656	molecular_function	3'-phosphoadenosine 5'-phosphosulfate binding
BcB	0055062	biological_process	phosphate ion homeostasis
BcB	0090304	biological_process	nucleic acid metabolic process
BcB	0106177	molecular_function	cyclic-GMP-AMP hydrolase activity
BcB	0110148	biological_process	obsolete biomineralization
BcB	1990787	biological_process	negative regulation of hh target transcription factor activity

Functional Information from PROSITE/UniProt

site_id	PS00524
Number of Residues	21
Details	SMB_1 Somatomedin B domain (SMB) signature. CrCdaaCvelgn.CClDYqetC

Chain	Residue	Details
AcA	CYS120-CYS140
AcA	CYS164-CYS184

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	150
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
AcA	MET1-LYS76
BcB	MET1-LYS76

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255

Chain	Residue	Details
AcA	VAL77-LEU97
BcB	VAL77-LEU97

---

site_id	SWS_FT_FI3
Number of Residues	1654
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
AcA	LYS98-ASP925
BcB	LYS98-ASP925

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	ACT_SITE: AMP-threonine intermediate => ECO:0000250|UniProtKB:P06802

Chain	Residue	Details
AcA	THR256
BcB	THR256

---

site_id	SWS_FT_FI5
Number of Residues	34
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P06802

Chain	Residue	Details
AcA	ASP218
AcA	HIS424
AcA	SER532
AcA	HIS535
AcA	ASP800
AcA	ASP802
AcA	ASP804
AcA	ARG806
AcA	ASP808
BcB	ASP218
BcB	THR256
AcA	THR256
BcB	ASN277
BcB	LEU290
BcB	LYS295
BcB	TYR340
BcB	ASP376
BcB	HIS380
BcB	ASP423
BcB	HIS424
BcB	SER532
BcB	HIS535
AcA	ASN277
BcB	ASP800
BcB	ASP802
BcB	ASP804
BcB	ARG806
BcB	ASP808
AcA	LEU290
AcA	LYS295
AcA	TYR340
AcA	ASP376
AcA	HIS380
AcA	ASP423

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	SITE: Cleavage => ECO:0000250|UniProtKB:P06802

Chain	Residue	Details
AcA	ALA102
BcB	ALA102

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	SITE: Essential for catalytic activity => ECO:0000250|UniProtKB:Q9R1E6

Chain	Residue	Details
AcA	LYS915
BcB	LYS915

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q924C3

Chain	Residue	Details
AcA	THR256
BcB	THR256

---

site_id	SWS_FT_FI9
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
AcA	ASN179
BcB	ASN585
BcB	ASN700
BcB	ASN731
AcA	ASN285
AcA	ASN477
AcA	ASN585
AcA	ASN700
AcA	ASN731
BcB	ASN179
BcB	ASN285
BcB	ASN477

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973

Chain	Residue	Details
AcA	ASN341
BcB	ASN341

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
AcA	ASN643
AcA	ASN748
BcB	ASN643
BcB	ASN748

---