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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6WFJ

Crystal structures of human E-NPP 1: apo

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AcA0003676molecular_functionnucleic acid binding
AcA0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
AcA0004527molecular_functionexonuclease activity
AcA0004528molecular_functionphosphodiesterase I activity
AcA0004551molecular_functiondinucleotide phosphatase activity
AcA0005044molecular_functionscavenger receptor activity
AcA0005158molecular_functioninsulin receptor binding
AcA0005509molecular_functioncalcium ion binding
AcA0005515molecular_functionprotein binding
AcA0005524molecular_functionATP binding
AcA0005576cellular_componentextracellular region
AcA0005615cellular_componentextracellular space
AcA0005765cellular_componentlysosomal membrane
AcA0005886cellular_componentplasma membrane
AcA0006091biological_processgeneration of precursor metabolites and energy
AcA0006796biological_processphosphate-containing compound metabolic process
AcA0006955biological_processimmune response
AcA0008270molecular_functionzinc ion binding
AcA0009143biological_processnucleoside triphosphate catabolic process
AcA0009986cellular_componentcell surface
AcA0010035biological_processobsolete response to inorganic substance
AcA0010467biological_processgene expression
AcA0016020cellular_componentmembrane
AcA0016192biological_processvesicle-mediated transport
AcA0016323cellular_componentbasolateral plasma membrane
AcA0016787molecular_functionhydrolase activity
AcA0016791molecular_functionphosphatase activity
AcA0030247molecular_functionpolysaccharide binding
AcA0030282biological_processbone mineralization
AcA0030308biological_processnegative regulation of cell growth
AcA0030318biological_processmelanocyte differentiation
AcA0030500biological_processregulation of bone mineralization
AcA0030502biological_processnegative regulation of bone mineralization
AcA0030505biological_processinorganic diphosphate transport
AcA0030643biological_processintracellular phosphate ion homeostasis
AcA0031214biological_processbiomineral tissue development
AcA0032869biological_processcellular response to insulin stimulus
AcA0033198biological_processresponse to ATP
AcA0036219molecular_functionGTP diphosphatase activity
AcA0036221molecular_functionUTP diphosphatase activity
AcA0042803molecular_functionprotein homodimerization activity
AcA0045599biological_processnegative regulation of fat cell differentiation
AcA0045719biological_processnegative regulation of glycogen biosynthetic process
AcA0046034biological_processATP metabolic process
AcA0046325biological_processnegative regulation of D-glucose import
AcA0046627biological_processnegative regulation of insulin receptor signaling pathway
AcA0046872molecular_functionmetal ion binding
AcA0047429molecular_functionnucleoside triphosphate diphosphatase activity
AcA0047693molecular_functionATP diphosphatase activity
AcA0048513biological_processanimal organ development
AcA0050427biological_process3'-phosphoadenosine 5'-phosphosulfate metabolic process
AcA0050656molecular_function3'-phosphoadenosine 5'-phosphosulfate binding
AcA0055062biological_processphosphate ion homeostasis
AcA0090304biological_processnucleic acid metabolic process
AcA0106177molecular_functioncyclic-GMP-AMP hydrolase activity
AcA0110148biological_processobsolete biomineralization
AcA1990787biological_processnegative regulation of hh target transcription factor activity
BcB0003676molecular_functionnucleic acid binding
BcB0004115molecular_function3',5'-cyclic-AMP phosphodiesterase activity
BcB0004527molecular_functionexonuclease activity
BcB0004528molecular_functionphosphodiesterase I activity
BcB0004551molecular_functiondinucleotide phosphatase activity
BcB0005044molecular_functionscavenger receptor activity
BcB0005158molecular_functioninsulin receptor binding
BcB0005509molecular_functioncalcium ion binding
BcB0005515molecular_functionprotein binding
BcB0005524molecular_functionATP binding
BcB0005576cellular_componentextracellular region
BcB0005615cellular_componentextracellular space
BcB0005765cellular_componentlysosomal membrane
BcB0005886cellular_componentplasma membrane
BcB0006091biological_processgeneration of precursor metabolites and energy
BcB0006796biological_processphosphate-containing compound metabolic process
BcB0006955biological_processimmune response
BcB0008270molecular_functionzinc ion binding
BcB0009143biological_processnucleoside triphosphate catabolic process
BcB0009986cellular_componentcell surface
BcB0010035biological_processobsolete response to inorganic substance
BcB0010467biological_processgene expression
BcB0016020cellular_componentmembrane
BcB0016192biological_processvesicle-mediated transport
BcB0016323cellular_componentbasolateral plasma membrane
BcB0016787molecular_functionhydrolase activity
BcB0016791molecular_functionphosphatase activity
BcB0030247molecular_functionpolysaccharide binding
BcB0030282biological_processbone mineralization
BcB0030308biological_processnegative regulation of cell growth
BcB0030318biological_processmelanocyte differentiation
BcB0030500biological_processregulation of bone mineralization
BcB0030502biological_processnegative regulation of bone mineralization
BcB0030505biological_processinorganic diphosphate transport
BcB0030643biological_processintracellular phosphate ion homeostasis
BcB0031214biological_processbiomineral tissue development
BcB0032869biological_processcellular response to insulin stimulus
BcB0033198biological_processresponse to ATP
BcB0036219molecular_functionGTP diphosphatase activity
BcB0036221molecular_functionUTP diphosphatase activity
BcB0042803molecular_functionprotein homodimerization activity
BcB0045599biological_processnegative regulation of fat cell differentiation
BcB0045719biological_processnegative regulation of glycogen biosynthetic process
BcB0046034biological_processATP metabolic process
BcB0046325biological_processnegative regulation of D-glucose import
BcB0046627biological_processnegative regulation of insulin receptor signaling pathway
BcB0046872molecular_functionmetal ion binding
BcB0047429molecular_functionnucleoside triphosphate diphosphatase activity
BcB0047693molecular_functionATP diphosphatase activity
BcB0048513biological_processanimal organ development
BcB0050427biological_process3'-phosphoadenosine 5'-phosphosulfate metabolic process
BcB0050656molecular_function3'-phosphoadenosine 5'-phosphosulfate binding
BcB0055062biological_processphosphate ion homeostasis
BcB0090304biological_processnucleic acid metabolic process
BcB0106177molecular_functioncyclic-GMP-AMP hydrolase activity
BcB0110148biological_processobsolete biomineralization
BcB1990787biological_processnegative regulation of hh target transcription factor activity
Functional Information from PROSITE/UniProt
site_idPS00524
Number of Residues21
DetailsSMB_1 Somatomedin B domain (SMB) signature. CrCdaaCvelgn.CClDYqetC
ChainResidueDetails
AcACYS120-CYS140
AcACYS164-CYS184
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues88
DetailsDomain: {"description":"SMB 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00350","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues50
DetailsRegion: {"description":"Linker","evidences":[{"source":"UniProtKB","id":"P06802","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsActive site: {"description":"AMP-threonine intermediate","evidences":[{"source":"UniProtKB","id":"P06802","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues34
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P06802","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsSite: {"description":"Essential for catalytic activity","evidences":[{"source":"UniProtKB","id":"Q9R1E6","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q924C3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues40
DetailsDomain: {"description":"SMB 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00350","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-12-24

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