6WDN
Cryo-EM structure of mitochondrial calcium uniporter holocomplex in low Ca2+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0006851 | biological_process | mitochondrial calcium ion transmembrane transport |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0006851 | biological_process | mitochondrial calcium ion transmembrane transport |
| C | 0051560 | biological_process | mitochondrial calcium ion homeostasis |
| D | 0036444 | biological_process | calcium import into the mitochondrion |
| D | 0051560 | biological_process | mitochondrial calcium ion homeostasis |
| D | 1990246 | cellular_component | uniplex complex |
| E | 0051560 | biological_process | mitochondrial calcium ion homeostasis |
| F | 0036444 | biological_process | calcium import into the mitochondrion |
| F | 0051560 | biological_process | mitochondrial calcium ion homeostasis |
| F | 1990246 | cellular_component | uniplex complex |
| G | 0051560 | biological_process | mitochondrial calcium ion homeostasis |
| H | 0036444 | biological_process | calcium import into the mitochondrion |
| H | 0051560 | biological_process | mitochondrial calcium ion homeostasis |
| H | 1990246 | cellular_component | uniplex complex |
| I | 0051560 | biological_process | mitochondrial calcium ion homeostasis |
| J | 0036444 | biological_process | calcium import into the mitochondrion |
| J | 0051560 | biological_process | mitochondrial calcium ion homeostasis |
| J | 1990246 | cellular_component | uniplex complex |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DLNGDGEVDmeEF |
| Chain | Residue | Details |
| B | ASP231-PHE243 | |
| B | ASP421-PHE433 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 168 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:31080062, ECO:0000269|PubMed:32494073, ECO:0000269|PubMed:32762847, ECO:0000269|PubMed:32862359, ECO:0007744|PDB:6K7X, ECO:0007744|PDB:6K7Y, ECO:0007744|PDB:6O58, ECO:0007744|PDB:6O5B, ECO:0007744|PDB:6WDN, ECO:0007744|PDB:6WDO, ECO:0007744|PDB:6XJV, ECO:0007744|PDB:6XJX |
| Chain | Residue | Details |
| C | LEU234-TRP255 | |
| C | MET263-MET284 | |
| G | LEU234-TRP255 | |
| G | MET263-MET284 | |
| I | LEU234-TRP255 | |
| I | MET263-MET284 | |
| E | LEU234-TRP255 | |
| E | MET263-MET284 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000305|PubMed:27099988, ECO:0000305|PubMed:31080062, ECO:0000305|PubMed:32494073, ECO:0000305|PubMed:32762847 |
| Chain | Residue | Details |
| C | TRP256-ILE262 | |
| G | TRP256-ILE262 | |
| I | TRP256-ILE262 | |
| E | TRP256-ILE262 | |
| B | GLU432 | |
| A | GLU386 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31080062, ECO:0000269|PubMed:32494073, ECO:0000269|PubMed:32862359, ECO:0007744|PDB:6K7X, ECO:0007744|PDB:6K7Y, ECO:0007744|PDB:6O58, ECO:0007744|PDB:6O5B, ECO:0007744|PDB:6WDO |
| Chain | Residue | Details |
| C | GLU264 | |
| G | GLU264 | |
| I | GLU264 | |
| E | GLU264 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q3UMR5 |
| Chain | Residue | Details |
| C | LYS332 | |
| G | LYS332 | |
| I | LYS332 | |
| E | LYS332 |
