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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6WDN

Cryo-EM structure of mitochondrial calcium uniporter holocomplex in low Ca2+

Functional Information from GO Data
ChainGOidnamespacecontents
A0005509molecular_functioncalcium ion binding
A0006851biological_processmitochondrial calcium ion transmembrane transport
B0005509molecular_functioncalcium ion binding
B0006851biological_processmitochondrial calcium ion transmembrane transport
C0051560biological_processmitochondrial calcium ion homeostasis
D0036444biological_processcalcium import into the mitochondrion
D0051560biological_processmitochondrial calcium ion homeostasis
D1990246cellular_componentuniplex complex
E0051560biological_processmitochondrial calcium ion homeostasis
F0036444biological_processcalcium import into the mitochondrion
F0051560biological_processmitochondrial calcium ion homeostasis
F1990246cellular_componentuniplex complex
G0051560biological_processmitochondrial calcium ion homeostasis
H0036444biological_processcalcium import into the mitochondrion
H0051560biological_processmitochondrial calcium ion homeostasis
H1990246cellular_componentuniplex complex
I0051560biological_processmitochondrial calcium ion homeostasis
J0036444biological_processcalcium import into the mitochondrion
J0051560biological_processmitochondrial calcium ion homeostasis
J1990246cellular_componentuniplex complex
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DLNGDGEVDmeEF
ChainResidueDetails
BASP231-PHE243
BASP421-PHE433
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues70
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues35
DetailsDomain: {"description":"EF-hand 3; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues35
DetailsDomain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31397067","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32790952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LB7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31397067","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IIH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues35
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues7
DetailsRegion: {"description":"K/R-ring","evidences":[{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues10
DetailsRegion: {"description":"C-helix region","evidences":[{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32790952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6LB7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8VCX5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Asymmetric dimethylarginine","evidences":[{"source":"PubMed","id":"27642082","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues44
DetailsTopological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"27099988","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27642048","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32762847","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues244
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32762847","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32862359","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WDN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XJV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XJX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues16
DetailsMotif: {"description":"GXXXX[G/A/S]","evidences":[{"source":"PubMed","id":"27099988","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues24
DetailsTopological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"27099988","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32762847","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues20
DetailsRegion: {"description":"Juxtamembrane helix","evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33296646","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues208
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues32
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31080062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32862359","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6K7X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6K7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O5B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WDO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3UMR5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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